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Autor:
Hani Yassin, Jesper Karup Pedersen, Jan N. Jensen, Palle Serup, Louise C. Rosenberg, Jacob Hecksher-Sørensen, Merete L. Lafon
Publikováno v:
Developmental Dynamics. 239:1950-1966
Neurog3 is expressed transiently in pancreatic endocrine progenitors where it is responsible for activating a transcription factor cascade which eventually defines the mature endocrine cells. However, the mechanism by which Neurog3 regulates differen
Publikováno v:
Developmental Dynamics. 235:3016-3025
Here, we examine the role of GDF11 in pancreatic development. Using in situ hybridization and reverse transcriptase-polymerase chain reaction analyses, we show that Gdf11 transcripts are expressed in embryonic pancreas epithelium before the secondary
Autor:
Hani Yassin, Anne Bødker, Jacob Hecksher-Sørensen, Jacob Hald, Jonas Ahnfelt-Rønne, Palle Serup
Publikováno v:
BMC Developmental Biology
BMC Developmental Biology, Vol 7, Iss 1, p 63 (2007)
BMC Developmental Biology, Vol 7, Iss 1, p 63 (2007)
Background Genetic studies have shown that formation of pancreatic endocrine cells in mice is dependent on the cell autonomous action of the bHLH transcription factor Neurogenin3 and that the extent and timing of endocrine differentiation is controll