Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Hani S. Zaher"'
Autor:
Jenna C. McGuffey, Clay D. Jackson-Litteken, Gisela Di Venanzio, Aubree A. Zimmer, Jessica M. Lewis, Jesus S. Distel, Kyusik Q. Kim, Hani S. Zaher, Juan Alfonzo, Nichollas E. Scott, Mario F. Feldman
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Successful pathogens must be able to adapt to a multitude of stressors imposed by their host. Acinetobacter baumannii has emerged as a major global health threat due to its exceptional ability to adapt to hostile environments and skyrocketin
Externí odkaz:
https://doaj.org/article/36fb02e91a4f408baf97b05f436e762d
Expansion of a novel population of NK cells with low ribosome expression in juvenile dermatomyositis
Autor:
Kinsey A. Hilliard, Allison A. Throm, Jeanette T. Pingel, Nermina Saucier, Hani S. Zaher, Anthony R. French
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Juvenile dermatomyositis (JDM) is a pediatric autoimmune disease associated with characteristic rash and proximal muscle weakness. To gain insight into differential lymphocyte gene expression in JDM, peripheral blood mononuclear cells from 4 new-onse
Externí odkaz:
https://doaj.org/article/5cfde86b4f994b67903261c7dc84a4bb
Autor:
Manasvi Verma, Junhong Choi, Kyle A. Cottrell, Zeno Lavagnino, Erica N. Thomas, Slavica Pavlovic-Djuranovic, Pawel Szczesny, David W. Piston, Hani S. Zaher, Joseph D. Puglisi, Sergej Djuranovic
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Several factors contribute to the efficiency of protein expression. Here the authors show that the identity of amino acids encoded by codons at position 3–5 significantly impact translation efficiency and protein expression levels.
Externí odkaz:
https://doaj.org/article/d6c7739bcd3d4753818faecc0bc65dc2
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The mRNA-surveillance pathway of no-go decay (NGD) is a eukaryotic ribosome-based-quality-control process that targets transcripts that stall the ribosome. Here the authors show no-go decay (NGD) and ribosome-quality control (RQC) pathways are activa
Externí odkaz:
https://doaj.org/article/4bdc7027d15d45759a4f1b0de623dfef
Autor:
Vanessa Oliveira, Nitin Mahajan, Melissa L. Bates, Chakrapani Tripathi, Kyusik Q. Kim, Hani S. Zaher, Leonard B. Maggi Jr, Michael H. Tomasson
Publikováno v:
FASEB BioAdvances, Vol 1, Iss 7, Pp 404-414 (2019)
Abstract The orphan small nucleolar RNA (snoRNA) ACA11 is overexpressed as a result of the t(4;14) chromosomal translocation in multiple myeloma (MM), increases reactive oxygen species, and drives cell proliferation. Like other snoRNAs, ACA11 is pred
Externí odkaz:
https://doaj.org/article/2c20f4e656694a63b1229336ad7e548f
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1679-1689.e4 (2019)
Summary: During translation, an mRNA is typically occupied by multiple ribosomes sparsely distributed across the coding sequence. This distribution, mediated by slow rates of initiation relative to elongation, ensures that they rarely collide with ea
Externí odkaz:
https://doaj.org/article/6f4bb86ba257466595903649907051b1
Autor:
William E. Pierson, Eric D. Hoffer, Hannah E. Keedy, Carrie L. Simms, Christine M. Dunham, Hani S. Zaher
Publikováno v:
Cell Reports, Vol 17, Iss 1, Pp 11-18 (2016)
Termination of protein synthesis on the ribosome is catalyzed by release factors (RFs), which share a conserved glycine-glycine-glutamine (GGQ) motif. The glutamine residue is methylated in vivo, but a mechanistic understanding of its contribution to
Externí odkaz:
https://doaj.org/article/5228e4d5939042f3a623ac302f9605bb
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1256-1264 (2014)
Chemical damage to RNA affects its functional properties and thus may pose a significant hurdle to the translational apparatus; however, the effects of damaged mRNA on the speed and accuracy of the decoding process and their interplay with quality-co
Externí odkaz:
https://doaj.org/article/f50420f8c82b433f87e8c99a77792a7a
Autor:
Braulio Bonilla, Alexander J Brown, Sarah R Hengel, Kyle S Rapchak, Debra Mitchell, Catherine A Pressimone, Adeola A Fagunloye, Thong T Luong, Reagan A Russell, Rudri K Vyas, Tony M Mertz, Hani S Zaher, Nima Mosammaparast, Ewa P Malc, Piotr A Mieczkowski, Steven A Roberts, Kara A Bernstein
Publikováno v:
eLife, Vol 10 (2021)
Three-methyl cytosine (3meC) are toxic DNA lesions, blocking base pairing. Bacteria and humans express members of the AlkB enzymes family, which directly remove 3meC. However, other organisms, including budding yeast, lack this class of enzymes. It r
Externí odkaz:
https://doaj.org/article/3c12084a8dba4d91b827c88a4ddb1f77
Publikováno v:
eLife, Vol 9 (2020)
Similar to DNA replication, translation of the genetic code by the ribosome is hypothesized to be exceptionally sensitive to small chemical changes to its template mRNA. Here we show that the addition of common alkylating agents to growing cultures o
Externí odkaz:
https://doaj.org/article/b6b0f4f6ef6647cc987e45cb4857ec52