Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Hani Houshyar"'
Autor:
Cristina St Pierre, Jane Guo, John D Shin, Laura W Engstrom, Hyun-Hee Lee, Alan Herbert, Laura Surdi, James Baker, Michael Salmon, Sanjiv Shah, J Michael Ellis, Hani Houshyar, Michael A Crackower, Melanie A Kleinschek, Dallas C Jones, Alexandra Hicks, Dennis M Zaller, Stephen E Alves, Ravisankar A Ramadas
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180870 (2017)
While the immune system is essential for the maintenance of the homeostasis, health and survival of humans, aberrant immune responses can lead to chronic inflammatory and autoimmune disorders. Pharmacological modulation of drug targets in the immune
Externí odkaz:
https://doaj.org/article/a511e5553a1e4c19982a055d21745012
Autor:
Robert C. Bucelli, Manjit McNeill, Shafeeq Ladha, Angela Genge, Stephanie Fradette, Ivan Nestorov, John Ravits, Philip Van Damme, Roger Lane, Christopher J McDermott, Jonathan Glass, Merit Cudkowicz, Laura Fanning, C. Frank Bennett, Heiko Runz, Ih Chang, Hani Houshyar, Toby A. Ferguson, Alfred Sandrock, Alan Pestronk, Danielle Graham, Timothy M. Miller, Randall G. Trudell, Nazem Atassi, Peter M. Andersen, François Salachas, Nicholas J. Maragakis, Albert L. Ludolph, Pamela J. Shaw, Lorne Zinman, Alexander McCampbell
Publikováno v:
New England Journal of Medicine. 383:109-119
Background Tofersen is an antisense oligonucleotide that mediates the degradation of superoxide dismutase 1 (SOD1) messenger RNA to reduce SOD1 protein synthesis. Intrathecal administratio...
Autor:
Jason D. Katz, François G. Gervais, Lauren Dorosh, Milenko Cicmil, Khamir Mehta, Joey L. Methot, Janice D Woodhouse, Hongshi Yu, Hani Houshyar, Prasanthi Geda, Gretchen A. Baltus, Malgorzata A Gil, Antonio Cabal, Sanjiv J. Shah, Robbie L. McLeod, Dapeng Chen, Alan S. Bass, Stephen E. Alves, Michael Caniga
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 369:223-233
We leveraged a clinical pharmacokinetic (PK)/pharmacodynamics (PD)/efficacy relationship established with an oral phosphatidylinositol 3-kinase (PI3K)δ inhibitor (Idelalisib) in a nasal allergen challenge study to determine whether a comparable PK/P
Autor:
Timothy, Miller, Merit, Cudkowicz, Pamela J, Shaw, Peter M, Andersen, Nazem, Atassi, Robert C, Bucelli, Angela, Genge, Jonathan, Glass, Shafeeq, Ladha, Albert L, Ludolph, Nicholas J, Maragakis, Christopher J, McDermott, Alan, Pestronk, John, Ravits, François, Salachas, Randall, Trudell, Philip, Van Damme, Lorne, Zinman, C Frank, Bennett, Roger, Lane, Alfred, Sandrock, Heiko, Runz, Danielle, Graham, Hani, Houshyar, Alexander, McCampbell, Ivan, Nestorov, Ih, Chang, Manjit, McNeill, Laura, Fanning, Stephanie, Fradette, Toby A, Ferguson
Publikováno v:
The New England journal of medicine. 383(2)
Tofersen is an antisense oligonucleotide that mediates the degradation of superoxide dismutase 1 (SOD1) messenger RNA to reduce SOD1 protein synthesis. Intrathecal administration of tofersen is being studied for the treatment of amyotrophic lateral s
Autor:
Robbie L, McLeod, Malgorzata A, Gil, Dapeng, Chen, Antonio, Cabal, Jason, Katz, Joey, Methot, Janice D, Woodhouse, Lauren, Dorosh, Prasanthi, Geda, Khamir, Mehta, Milenko, Cicmil, Gretchen A, Baltus, Alan, Bass, Hani, Houshyar, Michael, Caniga, Hongshi, Yu, Francois, Gervais, Stephen, Alves, Sanjiv, Shah
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 369(2)
We leveraged a clinical pharmacokinetic (PK)/pharmacodynamics (PD)/efficacy relationship established with an oral phosphatidylinositol 3-kinase (PI3K)
Autor:
Hani Houshyar, Alanna R. Darling, Joseph S. Zhou, Magali Noval Rivas, Kyle J. Koleoglou, Michael A. Crackower, Oliver T. Burton, Axel Roers, Hans C. Oettgen, Stephanie L. Logsdon, Talal A. Chatila
Publikováno v:
Immunity. 41:141-151
SummaryImmunoglobulin E (IgE) antibodies are known for triggering immediate hypersensitivity reactions such as food anaphylaxis. In this study, we tested whether they might additionally function to amplify nascent antibody and T helper 2 (Th2) cell-m
Autor:
Emily Hickey, Stella H. Vincent, Hongshi Yu, John H. Shin, Michael A. Crackower, Hyun-Hee Lee, Malgorzata A Gil, Michael Caniga, Jessica P. Alexander, Lily Y. Moy, Alan B. Northrup, Gissela Lieber, Richard L. Miller, Richard W. Chapman, Erich E Sirkowski, Thomas A. Miller, Yanlin Jia, Hani Houshyar, Nancy Kelly, J. Michael Ellis, Xiomara Fernandez, Alan Wilhelm, Hongmin Chen, William M. Abraham
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:1085-1092
Spleen tyrosine kinase (SYK) is a key activator of signaling pathways downstream of multiple surface receptors implicated in asthma. SYK function has been extensively studied in mast cells downstream of the high-affinity IgE receptor, FcεR1. Preclin
Autor:
Sheila M. Galloway, Binyuan Sun, Nancy Kelly, John W. Butcher, Grace H. C. Woo, Kerrie Spencer, J. Michael Ellis, Ryan D. Otte, Ekundayo Osimboni, Alan S. Bass, Sandra Lee, J. Richard Miller, Chiming Yang, Erica Leccese, Andrew M. Haidle, Alan B. Northrup, Lily Y. Moy, James P. Jewell, Alan Byford, Hani Houshyar, Gwendolyn J. Ward, Anthony Donofrio, Matthew L. Maddess, Michael D. Altman, M. Vijay Reddy, Stella H. Vincent
Publikováno v:
Journal of medicinal chemistry. 58(4)
Development of a series of highly kinome-selective spleen tyrosine kinase (Syk) inhibitors with favorable druglike properties is described. Early leads were discovered through X-ray crystallographic analysis, and a systematic survey of cores within a
Autor:
Abigail B. Ginsberg, Susanne E. la Fleur, Francisca Gomez, Kevin D. Laugero, Mary F. Dallman, Hani Houshyar, Susan F. Akana, Norman C. Pecoraro, James P. Warne, Aditi Bhargava
Publikováno v:
Progress in neurobiology. 79(5-6):247-340
The hypothalamo-pituitary-adrenal (HPA) axis is the critical mediator of the vertebrate stress response system, responding to environmental stressors by maintaining internal homeostasis and coupling the needs of the body to the wants of the mind. The
Autor:
James H. Woods, Susan K Wood, Hani Houshyar, Kenner C. Rice, Emily M. Jutkiewicz, Ling-Wei Hsin
Publikováno v:
Psychopharmacology. 180:215-223
Exposure to extreme stress has been suggested to produce long-term, detrimental alterations in the hypothalamic-pituitary-adrenal (HPA) axis leading to the development of mental disorders such as depression. Therefore, compounds that block the effect