Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway

Autor: Mohamed A. Ghonim, Jeffrey Wang, Salome V. Ibba, Hanh H. Luu, Kusma Pyakurel, Ilyes Benslimane, Shaker Mousa, A. Hamid Boulares

Publikováno v: Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-12 (2018)

Abstract Background The efficacy of heparins and low-MW-heparins (LMWH) against human asthma has been known for decades. However, the clinical utility of these compounds has been hampered by their anticoagulant properties. Much effort has been put in

Externí odkaz: https://doaj.org/article/9f367d95146e4c9fafcc7be9fc3fbb45

Abstract 4211: Minocycline-based metronomic therapy as a novel approach to enhance anti-tumor immune responses and reduce tumor burden in mouse models of colorectal cancer

Autor: Salome V. Ibba, Hanh H. Luu, Mohamed Ghonim, Cecilia Vittori, Matthew J. Dean, Giulia Monticone, Francesca Peruzzi, Augusto Ochoa, Lucio Miele, Hamid A. Boulares

Publikováno v: Cancer Research. 82:4211-4211

Despite the availability of numerous new therapies including immune checkpoint inhibitors, patients with colon cancer are faced with limited treatment options. We recently demonstrated that low metronomic dose of PARP inhibitor synergizes with anti-P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8dc9bdfdf759a5633c8caf257d07ae6
https://doi.org/10.1158/1538-7445.am2022-4211

Low Doses of PARP Inhibitors As A novel Therapeutic Approach to Enhance The Anti‐Cancer Immunotherapy of PD‐1 Immune Checkpoint Blockade

Autor: Augusto C. Ochoa, Hanh H Luu, Mohamed A. Ghonim, Abdelmetalab Tarhuni, Hamid Boulares, Matthew D. Dean, Amir A. Al-Khami

Publikováno v: The FASEB Journal. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8c777e0925232eb496440e787f8427f
https://doi.org/10.1096/fasebj.2019.33.1_supplement.680.15

DNA‐PK Is Activated in Human Atherosclerotic Plaques And Its Partial Inhibition by Gene Heterozygosity Reduces Atherogenesis in Mouse Model of The Disease

Autor: Hernan Bazan, Mohamed A. Ghonim, Matthew D. Dean, Hamid Boulares, Hanh H Luu, Kusma Pyakurel

Publikováno v: The FASEB Journal. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::560c1279c16318976a2cf5f453ff5fe6
https://doi.org/10.1096/fasebj.2018.32.1_supplement.570.2

Sulindac sulfide as a non-immune suppressive γ-secretase modulator to target triple-negative breast cancer.

Autor: Hossain F; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Ucar DA; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Monticone G; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Ran Y; Department of Pharmacological and Chemical Biology, Emory University, Atlanta, GA, United States., Majumder S; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Larter K; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Luu H; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Wyczechowska D; Department of Interdisciplinary Oncology, LSUHSC-NO, New Orleans, LA, United States., Heidari S; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Xu K; Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS, United States., Shanthalingam S; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, United States., Matossian M; School of Medicine, Tulane University, New Orleans, LA, United States., Xi Y; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Burow M; School of Medicine, Tulane University, New Orleans, LA, United States., Collins-Burow B; School of Medicine, Tulane University, New Orleans, LA, United States., Del Valle L; Department of Interdisciplinary Oncology, LSUHSC-NO, New Orleans, LA, United States.; Department of Pathology, Louisiana State University Health Sciences Center - New Orleans (LSUHSC-NO), New Orleans, LA, United States., Hicks C; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Zabaleta J; Department of Interdisciplinary Oncology, LSUHSC-NO, New Orleans, LA, United States., Golde T; Department of Pharmacological and Chemical Biology, Emory University, Atlanta, GA, United States., Osborne B; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, United States., Miele L; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Oct 13; Vol. 14, pp. 1244159. Date of Electronic Publication: 2023 Oct 13 (Print Publication: 2023).