Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway

Autor: Mohamed A. Ghonim, Jeffrey Wang, Salome V. Ibba, Hanh H. Luu, Kusma Pyakurel, Ilyes Benslimane, Shaker Mousa, A. Hamid Boulares

Publikováno v: Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-12 (2018)

Abstract Background The efficacy of heparins and low-MW-heparins (LMWH) against human asthma has been known for decades. However, the clinical utility of these compounds has been hampered by their anticoagulant properties. Much effort has been put in

Externí odkaz: https://doaj.org/article/9f367d95146e4c9fafcc7be9fc3fbb45

Promotion of a synthetic degradation of activated STAT6 by PARP-1 inhibition: roles of poly(ADP-ribosyl)ation, calpains and autophagy

Autor: Jeffrey Wang, Mohamed A. Ghonim, Salome V. Ibba, Hanh H. Luu, Yucel Aydin, Peter A. Greer, A. Hamid Boulares

Publikováno v: Journal of translational medicine. 20(1)

Background We reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively through a calpain-dependent mechanism. We wished to decipher the PARP-1/STAT6 relationship in the context

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8831a1c96af4ae7d4d8f6801f23c276b
https://pubmed.ncbi.nlm.nih.gov/36348405

Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway

Autor: Ilyes Benslimane, Mohamed A. Ghonim, A. Hamid Boulares, Hanh H Luu, Shaker A. Mousa, Jeffrey Wang, Salome V. Ibba, Kusma Pyakurel

Publikováno v: Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-12 (2018)
Journal of Translational Medicine

Background The efficacy of heparins and low-MW-heparins (LMWH) against human asthma has been known for decades. However, the clinical utility of these compounds has been hampered by their anticoagulant properties. Much effort has been put into harnes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf48aa3f6f1e50b94a2e0f4ac001136
http://link.springer.com/article/10.1186/s12967-018-1621-5

Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer

Autor: Augusto C. Ochoa, A. Hamid Boulares, Mohamed A. Ghonim, Luis Del Valle, Abdelmetalab Tarhuni, Amir A. Al-Khami, Dorota Wyczechowska, Ilyes Benslimane, Ali H. El-Bahrawy, Hanh H Luu, Matthew Dean, Salome V. Ibba, Youssef Errami

Publikováno v: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)

BackgroundPoly(ADP-ribose) polymerase (PARP) inhibitors (eg, olaparib) are effective against BRCA-mutated cancers at/near maximum tolerated doses by trapping PARP-1 on damaged chromatin, benefitting only small patient proportions. The benefits of tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7e33fb8bd0a0754e0ae9e654343c2b
https://doi.org/10.1136/jitc-2020-001643

Sulindac sulfide as a non-immune suppressive γ-secretase modulator to target triple-negative breast cancer.

Autor: Hossain F; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Ucar DA; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Monticone G; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Ran Y; Department of Pharmacological and Chemical Biology, Emory University, Atlanta, GA, United States., Majumder S; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Larter K; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Luu H; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Wyczechowska D; Department of Interdisciplinary Oncology, LSUHSC-NO, New Orleans, LA, United States., Heidari S; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Xu K; Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS, United States., Shanthalingam S; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, United States., Matossian M; School of Medicine, Tulane University, New Orleans, LA, United States., Xi Y; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Burow M; School of Medicine, Tulane University, New Orleans, LA, United States., Collins-Burow B; School of Medicine, Tulane University, New Orleans, LA, United States., Del Valle L; Department of Interdisciplinary Oncology, LSUHSC-NO, New Orleans, LA, United States.; Department of Pathology, Louisiana State University Health Sciences Center - New Orleans (LSUHSC-NO), New Orleans, LA, United States., Hicks C; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States., Zabaleta J; Department of Interdisciplinary Oncology, LSUHSC-NO, New Orleans, LA, United States., Golde T; Department of Pharmacological and Chemical Biology, Emory University, Atlanta, GA, United States., Osborne B; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, United States., Miele L; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans (LSUHSC-NO), New Orleans, LA, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Oct 13; Vol. 14, pp. 1244159. Date of Electronic Publication: 2023 Oct 13 (Print Publication: 2023).