Abstract 2700: ORM-6151: A first-in-class CD33-antibody enabled GSPT1 degrader for AML

Autor: James Palacino, Pedro Lee, Hangyeol Jeong, Yeonjoon Kim, Yoojin Song, Uttapol Permpoon, Wesley Wong, Chen Bai, Nathan Fishkin, Khuloud Takouri, Eunjun Yu, Yong Yi, Anna Skaletskaya, Min-Soo Kim, Da-Yeong Kim, Dong-Ki Choi, Peter U. Park

Publikováno v: Cancer Research. 83:2700-2700

Targeted protein degraders (TPDs) have expanded the breadth of therapeutic options through both their catalytic mechanism of action and ability to degrade previously “undruggable” target proteins. Prior reports of small-molecule GSPT1 degraders s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71b86ce68b21ee643f8dfae287c1ca67
https://doi.org/10.1158/1538-7445.am2023-2700

Abstract 3933: ORM-5029: A first-in-class targeted protein degradation therapy using antibody neodegrader conjugate (AnDC) for HER2-expressing breast cancer

Autor: James Palacino, Chen Bai, Yong Yi, Anna Skaletskaya, Khuloud Takrouri, Wesley Wong, Min-Soo Kim, Dong-Ki Choi, Da-Young Kim, Yeonhee Yang, Jiae Kook, Pedro Lee, Hangyeol Jeong, Sang-Mi Jee, Jiyun Park, Ki-Hwan Chang, Nathan Fishkin, Peter U. Park

Publikováno v: Cancer Research. 82:3933-3933

Targeted protein degradation (TPD) molecules, including IMiD-based molecular glues and heterobifunctional degraders have expanded the breadth of therapeutic options through both their catalytic mechanism of action and ability to degrade previously �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3721e0df43cd095effb959ab01db3fd9
https://doi.org/10.1158/1538-7445.am2022-3933

Discovery of 4H-chromeno[2,3-d]pyrimidin-4-one derivatives as senescence inducers and their senescence-associated antiproliferative activities on cancer cells using advanced phenotypic assay

Autor: Sangmi Oh, Kwanghan Kong, Seijin Park, Myung Jin Kim, Do Yoon Kwon, Hangyeol Jeong, Young-Mi Kim, Sujin Ahn, Haejin Kwon, Ji Young Lee, Arnaud Ogier, Hwankyu Kang, Inhee Choi, Rita Song, Ulf Nehrbass, Sook Jin Son

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2021, 209, pp.112550-. ⟨10.1016/j.ejmech.2020.112550⟩

Current research suggests therapy-induced senescence (TIS) of cancer cells characterized by distinct morphological and biochemical phenotypic changes represent a novel functional target that may enhance the effectiveness of cancer therapy. In order t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd59b88a5343fdf6c8325aca3d20fb1e
https://doi.org/10.1016/j.ejmech.2020.112550