Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Hangxiang Wang"'
Autor:
Lulu Ren, Jianqin Wan, Xiaoyan Li, Jie Yao, Yan Ma, Fanchao Meng, Shusen Zheng, Weidong Han, Hangxiang Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The immunosuppressive tumor microenvironment (TME) remains a major obstacle to tumor control and causes suboptimal responses to immune checkpoint blockade (ICB) therapy. Thus, developing feasible therapeutic strategies that trigger inflammat
Externí odkaz:
https://doaj.org/article/c80ba6f980094d91abb18d762bff89e5
Autor:
Hong Tang, Dilinuer Dilimulati, Zhentao Yang, Ke Zhou, Xiaona Chen, Ruiqi Sun, Ning Wang, Zhi Liang, Suchen Bian, Jialing Zhao, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105099- (2024)
Summary: Background: Hepatocellular carcinoma (HCC) is a highly prevalent and deadly type of cancer, and although pharmacotherapy remains the cornerstone of treatment, therapeutic outcomes are often unsatisfactory. Pharmacological inhibition of mamma
Externí odkaz:
https://doaj.org/article/4d7a06d987e2400bbd6e7f805b9cd9c9
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The often immune-suppressive tumor microenvironment (TME) may hinder immune evasion and response to checkpoint blockade therapies. Pharmacological activation of the STING pathway does create an immunologically hot TME, however, systemic deli
Externí odkaz:
https://doaj.org/article/575c20c070614e4ebee6392b4a45c9b9
Publikováno v:
Journal of Advanced Research, Vol 47, Iss , Pp 93-103 (2023)
Introduction: Organosilica nanoparticles (ONs), which are a new type of photoluminescent nanomaterial (PM) with excellent biocompatibility, have caught more attention in recent years. However, their applications are significantly impeded by the compl
Externí odkaz:
https://doaj.org/article/2eabf5e8f62a44308b10c2a6edef3e42
Publikováno v:
Materials Today Advances, Vol 20, Iss , Pp 100428- (2023)
Carbon nanodots (CDs) have received huge attention of researchers due to their good optical properties. However, CDs generally suffer from severely fluorescence self-quenching once they are aggregated or in solid state, limitating their applications
Externí odkaz:
https://doaj.org/article/cf557280557c4d099f99542e79b67592
Publikováno v:
Drug Delivery, Vol 30, Iss 1 (2023)
AbstractInflammatory bowel disease (IBD) is one of the most common intestinal disorders, with increasing global incidence and prevalence. Numerous therapeutic drugs are available but require intravenous administration and are associated with high tox
Externí odkaz:
https://doaj.org/article/37998df6be9d448097074178edc4f8a8
Autor:
Kangkang Ying, Yifeng Zhu, Jianqin Wan, Chenyue Zhan, Yuchen Wang, Binbin Xie, Peirong Xu, Hongming Pan, Hangxiang Wang
Publikováno v:
Bioactive Materials, Vol 20, Iss , Pp 449-462 (2023)
The recent remarkable success and safety of mRNA lipid nanoparticle technology for producing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has stimulated intensive efforts to expand nanoparticle strategies to treat various dis
Externí odkaz:
https://doaj.org/article/d19fd9f1554644068140a544ecc43b13
Autor:
Jian Wang, Peirong Xu, Yeyong Zhang, Shuai Han, Gongteng Wang, Hangxiang Wang, Haihan Song, Shufeng Li
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107409- (2023)
Summary: Supramolecular prodrug self-assembly is a cost-effective and powerful approach for creating injectable anticancer nanoassemblies. Herein, we describe the self-assembly of small-molecule prodrug nanotherapeutics for tumor-restricted pharmacol
Externí odkaz:
https://doaj.org/article/e6d883e10c444c8cb0cd58ce1d9924c6
Autor:
Zhentao Yang, Haiyang Xie, Jianqin Wan, Yuchen Wang, Liang Zhang, Ke Zhou, Hong Tang, Wentao Zhao, Hangxiang Wang, Penghong Song, Shusen Zheng
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104594- (2023)
Summary: Background: Long-term treatment with immunosuppressants is necessary to attenuate allograft rejection following organ transplantation (OT). Consequently, the overall survival of OT recipients with malignancies has been substantially compromi
Externí odkaz:
https://doaj.org/article/12f4aa1a9e144b648e9502e2ce75d74c
Autor:
Xiaowei Shi, Liwei Shu, Minwen Wang, Jie Yao, Qigu Yao, Suchen Bian, Xiaona Chen, Jianqin Wan, Fu Zhang, Shusen Zheng, Hangxiang Wang
Publikováno v:
Advanced Science, Vol 10, Iss 15, Pp n/a-n/a (2023)
Abstract Immune checkpoint blockade (ICB) therapies have had a tremendous impact on cancer therapy. However, most patients harbor a poorly immunogenic tumor microenvironment (TME), presenting overwhelming de novo refractoriness to ICB inhibitors. To
Externí odkaz:
https://doaj.org/article/e7b49f998c8a46f4a01132d0265aae89