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Inhibition of Human Stromelysin by Peptides Based on the N-Terminal Domain of Tissue Inhibitor of Metalloproteinases-1

Autor: A. Lugo, Robert L. Walsky, M. Visnick, N. Fotouhi, A. C. Hanglow, John W. Coffey

Publikováno v: Biochemical and Biophysical Research Communications. 205:1156-1163

The tissue inhibitors of metalloproteinases (TIMPs) represent a family of naturally occurring protein inhibitors of stromelysin and other members of the family of matrix metalloproteinases. A series of peptides based on the N-terminal sequence of nat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fddf090ace952990c472e737903cd4
https://doi.org/10.1006/bbrc.1994.2787

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Potent peptide inhibitors of stromelysin based on the prodomain region of matrix metalloproteinases

Autor: John W. Coffey, L. Lusch, M. Visnick, A. C. Hanglow, N. Fotouhi, A. Lugo, Robert L. Walsky

Publikováno v: Journal of Biological Chemistry. 269:30227-30231

Stromelysin is secreted as an inactive zymogen that is activated in the extracellular space by cleavage of the His81-Phe82 bond with the release of the 81-amino acid propeptide domain. This segment contains a 12-amino acid sequence (MRKPRC75GVPDVG) t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76e2b6548aecb2b607c41606e2d28305
https://doi.org/10.1016/s0021-9258(18)43801-x

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The design and synthesis of potent cyclic peptide VCAM–VLA-4 antagonists incorporating an achiral Asp-Pro mimetic

Autor: Pramod Joshi, Angela Hanglow, Karen Rowan, Jefferson Wright Tilley, Charles M. Cook, Gerry Kaplan, Barry A. Wolitzky, Nader Fotouhi, David C. Fry, Virginia Schwinge

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:1171-1173

The Asp-Pro sequence of the cyclic peptide Ac-HN-Tyr-Cys*-Asp-Pro-Cys*-OH (1) could be replaced with the achiral dipeptide mimetic 1-(2-aminoethyl)cyclpentylcarboxylic acid with retention of potent inhibition of the VCAM-VLA-4 interaction.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95eeb8bf78bfdbddf88b03b36317d223
https://doi.org/10.1016/s0960-894x(00)00174-8

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Macrophage-mediated killing of splenic lymphocytes in adjuvant-induced arthritis

Autor: A. C. Hanglow, John W. Coffey, H. Bachmann

Publikováno v: Agents and Actions. 34:11-15

After 72 hrs in culture, unseparated spleen cells from rats with adjuvant-induced arthritis (AA) stimulated with high concentrations of Con A (greater than 0.63 micrograms/ml) leaked more lactate dehydrogenase (LDH) than did either unstimulated cultu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7336a1a9a778c4524c72cbfaa9f87c45
https://doi.org/10.1007/bf01993224

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Effects of a novel anti-inflammatory retinoid-like 2,4,6,8-nonatetraenoic acid on the immunological changes associated with adjuvant-induced arthritis

Autor: John W. Coffey, A. C. Hanglow, Michael Rosenberger, H. Bachmann

Publikováno v: International Journal of Immunopharmacology. 12:703-712

Proliferative responses to the T-cell mitogen, Con A, were markedly suppressed in spleen cells isolated from rats 12-16 days following induction of adjuvant-induced arthritis (AA). These responses were only partially restored following removal of pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed84613a3fa3c11d2a4d80487b98e51
https://doi.org/10.1016/0192-0561(90)90032-i

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Eicosanoid production and phospholipase A2 secretion by peritoneal macrophages from rats with adjuvant-induced arthritis

Autor: A. C. Hanglow, Celia M. Anderson, Douglas W. Morgan, C. E. T. Bak

Publikováno v: Agents and Actions. 34:81-83

The effect of adjuvant-induced arthritis on rat peritoneal macrophage (RPM) function with respect to [14C]arachidonic acid (AA) release, leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) production, and secreted phospholipase A2 (PLA2) activity was i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c32cc4353f5b10e849c83a50777717a
https://doi.org/10.1007/bf01993244

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