Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hangchun Zhang"'
Autor:
Laura Sepp-Lorenzino, Hangchun Zhang, Yi Pei, South Victoria J, Steven L. Colletti, Wonsuk Chang, Daniel Zewge, Matthew G. Stanton, Jillian DiMuzio, Edward C. Sherer, Craig A. Parish, Erin N. Guidry, Walter Strapps
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4513-4517
Single-stranded silencing RNAs (ss siRNA), while not as potent as duplex RNAs, have the potential to become a novel platform technology in RNA interference based gene silencing by virtue of their simplicity and plausibly favorable characteristics in
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 63:168-173
Introduction Quantitative pharmacokinetic measurement of short nucleotide sequences in animal tissues is critical to the successful development of siRNA-based drugs. Stem-loop qRT-PCR is a sensitive and precise methodology, but the effect of biologic
Autor:
Marc Abrams, Jessica Seitzer, Laura Sepp-Lorenzino, Yi Pei, René Bartz, Paul A. Burke, Nathalie Innocent, Yan Xu, Stanley F. Barnett, Craig Cherrin, Colin J. Pomerantz, Paula J. Hancock, Hangchun Zhang, Martin Koser, Alan B. Sachs, Nelly A. Kuklin
Publikováno v:
RNA. 16:2553-2563
Effective small interfering RNA (siRNA)–mediated therapeutics require the siRNA to be delivered into the cellular RNA-induced silencing complex (RISC). Quantitative information of this essential delivery step is currently inferred from the efficacy
Autor:
Cook James C, John W. Shiver, Adam C. Finnefrock, Daria J. Hazuda, Riccardo Cortese, David Bramhill, Joseph G. Joyce, Richard Hampton, Stephen Jarantow, Zhiqiang An, Mayuri Patel, Paolo Ingallinella, Gaetano Barbato, Christopher Lloyd, Peter S. Kim, David Lowe, Jane K. Osbourn, Emilio A. Emini, Renee Hrin, Hangchun Zhang, Romas Geleziunas, Gennaro Ciliberto, Tristan J. Vaughan, Ping Lu, Michael McElhaugh, William R. Strohl, Meiqing Lu, William A. Schleif, Simon N Lennard, Elisabetta Bianchi, Michael D. Miller, Antonello Pessi, Steven Lane, Marco Finotto, Marco Mattu, Debra M. Eckert
Publikováno v:
Proceedings of the National Academy of Sciences
HIV-1 entry into cells is mediated by the envelope glycoprotein receptor-binding (gp120) and membrane fusion-promoting (gp41) subunits. The gp41 heptad repeat 1 (HR1) domain is the molecular target of the fusion-inhibitor drug enfuvirtide (T20). The
Autor:
Michael Ernest Pierce, Jing-Tao Wu, John W. Mellors, Romas Geleziunas, Lee T. Bacheler, Michael J. Otto, Dennis C. Liotta, George L. Trainor, Hammond Jennifer, Douglas J. Manion, Sharon Diamond, Holly Bazmi, Susan Erickson-Viitanen, Hangchun Zhang, Lieven Stuyver, M. M. Rayner, Ronald M. Klabe, Sena Garber, Karen Gallagher, Raymond F. Schinazi
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:1394-1401
Highly active antiretroviral therapy (HAART) is the standard treatment for infection with the human immunodeficiency virus (HIV). HAART regimens consist of protease inhibitors or nonnucleoside reverse transcriptase inhibitors combined with two or mor
Publikováno v:
The Journal of Immunology. 164:5369-5374
The RhoA GTPase is involved in regulating actin cytoskeletal organization, gene expression, cell proliferation, and survival. We report here that p115-RhoGEF, a specific guanine nucleotide exchange factor (GEF) and activator of RhoA, modulates HIV-1
Autor:
Anthony Leone, Hangchun Zhang, Leticia Arrington, Lei Wang, Ye Zhang, Angela Glass, Jingtao Zhang, Yi Pei
Publikováno v:
Molecular pharmaceutics. 10(1)
A primary consideration when developing lipid nanoparticle (LNP) based small interfering RNA (siRNA) therapeutics is formulation polydispersity or heterogeneity. The level of heterogeneity of physicochemical properties within a pharmaceutical batch c
Publikováno v:
Virology. 212(2):686-697
Rapidly replicating, cytopathic (rr/cpe+) variants of hepatitis A virus (HAV) isolated from persistently infected BS-C-1 cells have numerous mutations from cell culture-adapted rr/cpe- HAV. To determine which mutations in one rr/cpe+ virus, HM175/18f
Autor:
Hangchun Zhang, Susan Erickson-Viitanen, Karen Gallagher, Lee T Bacheler, Sena Garber, Guoen Shi, Michael J. Otto, Jing-Tao Wu, Romas Geleziunas, Raymond F. Schinazi
Publikováno v:
Antiviral chemistrychemotherapy. 14(1)
Nucleoside reverse transcriptase inhibitors (NRTIs) represent the cornerstone of highly active antiretroviral therapy when combined with non-nucleoside reverse transcriptase inhibitors (NNRTIs) or HIV-1 protease inhibitors (PIs). Unlike the NNRTIs an
Secondary structure of the 5′ nontranslated regions of hepatitis C virus and pestivirus genomic RNAs
The RNA genomes of human hepatitis C virus (HCV) and the animal pestiviruses responsible for bovine viral diarrhea (BVDV) and hog cholera (HChV) have relatively lengthy 5' nontranslated regions (5'NTRs) sharing short segments of conserved primary nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549576d54949f80f179e12c958c7ac0a