Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Hangchuan Shi"'
Autor:
Qiang Wen, Rui Zhang, Kejun Ye, Jun Yang, Hangchuan Shi, Zhu Liu, Yangpeng Li, Ting Liu, Shiyu Zhang, Wanpei Chen, Jingjing Wu, Weichao Liu, Xiaoqiu Tan, Ming Lei, Christopher L.-H. Huang, Xianhong Ou
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract We explored physiological effects of the sodium-glucose co-transporter-2 inhibitor empagliflozin on intact experimentally hypertrophic murine hearts following transverse aortic constriction (TAC). Postoperative drug (2–6 weeks) challenge r
Externí odkaz:
https://doaj.org/article/7a7224d6282a486ca9a2c8a589c4d075
Autor:
Dan Zhang, Qiang Wen, Rui Zhang, Kun Kou, Miao Lin, Shiyu Zhang, Jun Yang, Hangchuan Shi, Yan Yang, Xiaoqiu Tan, Shigang Yin, Xianhong Ou
Publikováno v:
Advanced Science, Vol 11, Iss 39, Pp n/a-n/a (2024)
Abstract Heart failure (HF) is a prevalent cardiovascular disease with significant morbidity and mortality rates worldwide. Due to the intricate structure of the heart, diverse cell types, and the complex pathogenesis of HF, further in‐depth invest
Externí odkaz:
https://doaj.org/article/eb4211eff0d54f34ac75ecbec3d30383
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Background: Physiological and pathological stimuli result in distinct forms of cardiac hypertrophy, but the molecular regulation comparing the two, especially at the DNA methylation level, is not well understood.Methods: We conducted an in vitro stud
Externí odkaz:
https://doaj.org/article/047737bcdbf14ab99622a302b3ec8423
Autor:
Hangchuan Shi, Deborah J. Ossip, Nicole L. Mayo, Daniel A. Lopez, Robert C. Block, Wendy S. Post, Alain G. Bertoni, Jingzhong Ding, Si Chen, Chen Yan, Zidian Xie, Ina Hoeschele, Yongmei Liu, Dongmei Li
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background The complexity of physical activity (PA) and DNA methylation interaction in the development of cardiovascular disease (CVD) is rarely simultaneously investigated in one study. We examined the role of DNA methylation on the associa
Externí odkaz:
https://doaj.org/article/6f13f519e27b4aaebec37802b32b3b86
Autor:
Hangchuan Shi, Zahíra Quiñones Tavárez, Zidian Xie, Liane M. Schneller, Daniel P. Croft, Maciej L. Goniewicz, Scott McIntosh, Richard J. O’Connor, Deborah J. Ossip, Irfan Rahman, Dongmei Li
Publikováno v:
Tobacco Induced Diseases, Vol 18, Iss October, Pp 1-9 (2020)
Introduction Flavors other than tobacco flavor have been identified as a major reason for electronic nicotine delivery system (ENDS) initiation in youth and are thought to contribute to the continued use of ENDS in users of all ages. Our previous res
Externí odkaz:
https://doaj.org/article/c350f5e7b9c5433a803f19c3112f5454
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 2 (2022)
Background cGMP‐hydrolyzing phosphodiesterase type 5 (PDE5) regulates vascular smooth muscle cell (SMC) contraction by antagonizing cGMP‐dependent protein kinase I (PKGI)–dependent SMC relaxation. SMC contractile dysfunction is implicated in th
Externí odkaz:
https://doaj.org/article/ec6714a7e37d4512bbdc566f5901346a
Publikováno v:
Toxics, Vol 9, Iss 3, p 52 (2021)
Following their introduction a decade ago, electronic cigarettes (e-cigarettes) have grown in popularity. Given their novelty, knowledge of the health consequences of e-cigarette use remains limited. Epidemiologic studies have not comprehensively exp
Externí odkaz:
https://doaj.org/article/0a30f2e0c109412f9eb9e274f5dc1600
Autor:
Guanghua Xu, Ning Lou, Yuchen Xu, Hangchuan Shi, Hailong Ruan, Wen Xiao, Lei Liu, Haibing Xiao, Bin Qiu, Lin Bao, Changfei Yuan, Ke Chen, Hongmei Yang, Xiaoping Zhang
Publikováno v:
Tumor Biology, Vol 39 (2017)
Aberrant expression of scavenger receptor class B type 1 has been reported in several human cancers. Nevertheless, the roles of scavenger receptor class B type 1 in clear cell renal cell carcinoma remain unclear. The aim of this study was to evaluate
Externí odkaz:
https://doaj.org/article/2b1c47351403405eabd7baeb775dc612
Autor:
Yishuai Zhang, Si Chen, Lingfeng Luo, Greenly, Sarah, Hangchuan Shi, Jiayuan Xu, Jasmine, Chen Yan
Publikováno v:
Circulation Research; 11/10/2023, Vol. 133 Issue 11, p902-923, 22p
Autor:
Si Chen, Jiawei Chen, Wenting Du, Deanne M. Mickelsen, Hangchuan Shi, Han Yu, Sparsh Kumar, Chen Yan
Publikováno v:
Circulation Research.
BACKGROUND: Cyclic nucleotides play critical roles in cardiovascular biology and disease. PDE10A (phosphodiesterase 10A) is able to hydrolyze both cAMP and cGMP. PDE10A expression is induced in various human tumor cell lines, and PDE10A inhibition su