A phase Ib dose escalation study of oral monotherapy with KX2-391 in elderly patients with acute myeloid leukemia.

Autor: Kasner MT; Thomas Jefferson University, 834 Chestnut Street, Philadelphia, PA, 19107, USA. margaret.kasner@jefferson.edu., Halloran MB; Thomas Jefferson University, 834 Chestnut Street, Philadelphia, PA, 19107, USA., Pan J; Cooper University Healthcare, 2 Cooper Plaza, Camden, NJ, 08103, USA., Ritchie EK; Weill Cornell Medicine, 530 East 70th Street, New York, NY, 10021, USA., Fetterly GJ; Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA., Kramer D; Athenex Pharmaceuticals, 701 Ellicott Street, Buffalo, NY, 14203, USA., Hangauer DG; Athenex Pharmaceuticals, 701 Ellicott Street, Buffalo, NY, 14203, USA., Thompson JE; Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.

Publikováno v: Investigational new drugs [Invest New Drugs] 2022 Aug; Vol. 40 (4), pp. 773-781. Date of Electronic Publication: 2022 May 17.

Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361).

Autor: Smolinski MP; Athenex Inc. , Conventus Building, 1001 Main Street, Suite 600 , Buffalo , New York 14203 , United States., Bu Y; Athenex Inc. , Conventus Building, 1001 Main Street, Suite 600 , Buffalo , New York 14203 , United States., Clements J; Athenex Inc. , Conventus Building, 1001 Main Street, Suite 600 , Buffalo , New York 14203 , United States., Gelman IH; Department of Cancer Genetics & Genomics , Roswell Park Comprehensive Cancer Center , Elm and Carlton Streets , Buffalo , New York 14263 , United States., Hegab T; Athenex Inc. , Conventus Building, 1001 Main Street, Suite 600 , Buffalo , New York 14203 , United States., Cutler DL; Athenex Inc. , Conventus Building, 1001 Main Street, Suite 600 , Buffalo , New York 14203 , United States., Fang JWS; Athenex Inc. , Conventus Building, 1001 Main Street, Suite 600 , Buffalo , New York 14203 , United States., Fetterly G; Athenex Inc. , Conventus Building, 1001 Main Street, Suite 600 , Buffalo , New York 14203 , United States., Kwan R; Athenex Inc. , Conventus Building, 1001 Main Street, Suite 600 , Buffalo , New York 14203 , United States., Barnett A; Athenex Inc. , Conventus Building, 1001 Main Street, Suite 600 , Buffalo , New York 14203 , United States., Lau JYN; Athenex Inc. , Conventus Building, 1001 Main Street, Suite 600 , Buffalo , New York 14203 , United States., Hangauer DG; Athenex Inc. , Conventus Building, 1001 Main Street, Suite 600 , Buffalo , New York 14203 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Jun 14; Vol. 61 (11), pp. 4704-4719. Date of Electronic Publication: 2018 Apr 17.

Ligand binding cooperativity: Bioisosteric replacement of CO with SO2 among thrombin inhibitors.

Autor: Said AM; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, United States; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Helwan University, Helwan, Egypt. Electronic address: ahmedmoh@buffalo.edu., Hangauer DG; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, United States. Electronic address: hangauer@buffalo.edu.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Aug 15; Vol. 26 (16), pp. 3850-4. Date of Electronic Publication: 2016 Jul 09.

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Targeting SRC and tubulin in mucinous ovarian carcinoma.

Autor: Liu T; Authors' Affiliations: Departments of Gynecologic Oncology and Reproductive Medicine, Genitourinary Medical Oncology, Bioinformatics and Computational Biology, and Cancer Biology; Division of Cancer Medicine; Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas; Kinex Pharmaceuticals LLC, New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, New York; Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei; Department of Gynecology, Obstetrics and Gynecology, Hospital of Fudan University, Shanghai, P.R. China., Hu W, Dalton HJ, Choi HJ, Huang J, Kang Y, Pradeep S, Miyake T, Song JH, Wen Y, Lu C, Pecot CV, Bottsford-Miller J, Zand B, Jennings NB, Ivan C, Gallick GE, Baggerly KA, Hangauer DG, Coleman RL, Frumovitz M, Sood AK

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2013 Dec 01; Vol. 19 (23), pp. 6532-43. Date of Electronic Publication: 2013 Oct 07.