Výsledky vyhledávání - "Hang-zi Chen"

Akademický článek

A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis

Autor: Lingli He, Liang Yuan, Wentao Yu, Yang Sun, Dan Jiang, Xiaodong Wang, Xue Feng, Zuoyun Wang, Jinjin Xu, Ruizeng Yang, Wenxiang Zhang, Hua Feng, Hang-zi Chen, Yi Arial Zeng, Lijian Hui, Qiao Wu, Yonglong Zhang, Lei Zhang

Publikováno v: Cell Reports, Vol 33, Iss 3, Pp 108284- (2020)

Summary: The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored. Here, we identify NR4A1 as a target of the Hi

Externí odkaz: https://doaj.org/article/3073b7c2389a4f9a8a749e7f97c29550

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Akademický článek

Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

Autor: Xue-li Bian, Hang-zi Chen, Peng-bo Yang, Ying-ping Li, Fen-na Zhang, Jia-yuan Zhang, Wei-jia Wang, Wen-xiu Zhao, Sheng Zhang, Qi-tao Chen, Yu Zheng, Xiao-yu Sun, Xiao-min Wang, Kun-Yi Chien, Qiao Wu

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Gluconeogenesis is downregulated in hepatocellular carcinoma. Here, the authors show that nuclear receptor Nur77 acts as a tumour suppressor sustaining gluconeogenesis by enhancing phosphoenolpyruvate carboxykinase (PEPCK1) stability via regulating i

Externí odkaz: https://doaj.org/article/08531e386b7c4c13a7c8af733ca4b208

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Akademický článek

The orphan receptor TR3 participates in angiotensin II‐induced cardiac hypertrophy by controlling mTOR signalling

Autor: Rong‐Hao Wang, Jian‐Ping He, Mao‐Long Su, Jie Luo, Ming Xu, Xiao‐Dan Du, Hang‐Zi Chen, Wei‐Jia Wang, Yuan Wang, Nan Zhang, Bi‐Xing Zhao, Wen‐Xiu Zhao, Zhong‐Gui Shan, Jiahuai Han, Chawnshang Chang, Qiao Wu

Publikováno v: EMBO Molecular Medicine, Vol 5, Iss 1, Pp 137-148 (2012)

Abstract Angiotensin II (AngII) induces cardiac hypertrophy and increases the expression of TR3. To determine whether TR3 is involved in the regulation of the pathological cardiac hypertrophy induced by AngII, we established mouse and rat hypertrophy

Externí odkaz: https://doaj.org/article/23dba93488c04328a0b77ee9974076f0

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HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma

Autor: Qi-tao Chen, Zhi-yuan Zhang, Qiao-ling Huang, Hang-zi Chen, Wen-bin Hong, Tianwei Lin, Wen-xiu Zhao, Xiao-min Wang, Cui-yu Ju, Liu-zheng Wu, Ya-ying Huang, Pei-pei Hou, Wei-jia Wang, Dawang Zhou, Xianming Deng, Qiao Wu

Publikováno v: Nature Metabolism. 4:1306-1321

Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells (HSCs), which f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907169b51334188bf5b7fe6f22afb396
https://doi.org/10.1038/s42255-022-00642-5

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Data from Flightless-I Blocks p62-Mediated Recognition of LC3 to Impede Selective Autophagy and Promote Breast Cancer Progression

Autor: Hang-Zi Chen, Qiao Wu, Allison J. Cowin, Qiu-Wan Wu, Zhi-Ming Zhang, Kun-Yi Chien, Xin-Dong Jiang, Xiaotong Li, Lu-Ming Yao, Ying-Ping Li, Peng-Bo Yang, Xiao-Yu Sun, Wei-Jia Wang, Qi-Tao Chen, Pei-Pei Hou, Jian-Ping He

p62 is a receptor that facilitates selective autophagy by interacting simultaneously with cargoes and LC3 protein on the autophagosome to maintain cellular homeostasis. However, the regulatory mechanism(s) behind this process and its association with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1927bce0e5f061c7619fa01d74debf95
https://doi.org/10.1158/0008-5472.c.6512172.v1

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