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Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency.

Autor: Pluvinage JV; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Ngo T; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Fouassier C; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., McDonagh M; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Holmes BB; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Bartley CM; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA.; Department of Psychiatry and Behavioral Sciences, UCSF, San Francisco, CA 94158, USA., Kondapavulur S; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA.; Department of Neurological Surgery, UCSF, San Francisco, CA 94158, USA., Hurabielle C; Department of Medicine, Division of Rheumatology, UCSF, San Francisco, CA, 94158, USA., Bodansky A; Department of Pediatrics, Division of Critical Care, UCSF, San Francisco, CA 94158, USA., Pai V; Bruker Cellular Analysis, Emeryville, CA, 94608, USA., Hinman S; Bruker Cellular Analysis, Emeryville, CA, 94608, USA., Aslanpour A; Bruker Cellular Analysis, Emeryville, CA, 94608, USA., Alvarenga BD; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Zorn KC; Department of Biochemistry and Biophysics, UCSF, San Francisco, CA 94158, USA., Zamecnik C; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., McCann A; Bevital, Bergen 5068, Norway., Asencor AI; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Huynh T; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Browne W; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Tubati A; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Haney MS; Department of Neurology, Stanford University, Stanford, CA 94304, USA., Douglas VC; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Louine M; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Cree BAC; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Hauser SL; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Seeley W; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Baranzini SE; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Wells JA; Department of Pharmaceutical Chemistry, UCSF, San Francisco, CA 94158, USA., Spudich S; Department of Neurology, Yale School of Medicine, New Haven, CT 06520, USA., Farhadian S; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT 06520, USA., Ramachandran PS; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Gillum L; Bass Medical Group, Pleasant Hill, CA 94523, USA., Hales CM; Department of Neurology, Emory University, Atlanta, GA 30322, USA., Zikherman J; Department of Medicine, Division of Rheumatology, UCSF, San Francisco, CA, 94158, USA., Anderson MS; Diabetes Center, UCSF, San Francisco, CA 94143, USA.; Department of Medicine, Division of Endocrinology, UCSF, San Francisco, CA 94158, USA., Yazdany J; Department of Neurological Surgery, UCSF, San Francisco, CA 94158, USA., Smith B; Division of Neuroimmunology and Neurovirology, National Institute of Neurologic Disorders and Stroke, Bethesda, MD 20824, USA., Nath A; Division of Neuroimmunology and Neurovirology, National Institute of Neurologic Disorders and Stroke, Bethesda, MD 20824, USA., Suh G; Department of Medicine, Division of Infectious Disease, Mayo Clinic, Rochester, MN 55905, USA., Flanagan EP; Department of Neurology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Green AJ; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Green R; Department of Pathology and Laboratory Medicine, University of California, Davis, CA 95616, USA., Gelfand JM; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., DeRisi JL; Bruker Cellular Analysis, Emeryville, CA, 94608, USA.; Chan Zuckerberg Biohub San Francisco, San Francisco, CA 94158, USA., Pleasure SJ; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA., Wilson MR; Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Jun 26; Vol. 16 (753), pp. eadl3758. Date of Electronic Publication: 2024 Jun 26.

APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia.

Autor: Haney MS; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Equal contribution., Pálovics R; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Equal contribution., Munson CN; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Long C; Department of Materials Science & Engineering Department, Stanford University, Stanford, CA 94305, USA., Johansson P; Department of Materials Science & Engineering Department, Stanford University, Stanford, CA 94305, USA., Yip O; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US., Dong W; The Institute for Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA., Rawat E; The Institute for Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA., West E; Department of Cellular and Molecular Medicine, University of California, San Diego, San Diego, CA 92093, USA., Schlachetzki JC; Department of Cellular and Molecular Medicine, University of California, San Diego, San Diego, CA 92093, USA., Tsai A; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Guldner IH; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Lamichhane BS; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Smith A; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Schaum N; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Calcuttawala K; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Shin A; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Wang YH; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US., Wang C; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US., Koutsodendris N; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US.; Development and Stem Cell Biology Graduate Program, University of California, San Francisco, US., Serrano GE; Laboratory of Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA., Beach TG; Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, AZ, USA., Reiman EM; Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, AZ, USA., Glass CK; Development and Stem Cell Biology Graduate Program, University of California, San Francisco, US., Abu-Remaileh M; The Institute for Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA., Enejder A; Department of Materials Science & Engineering Department, Stanford University, Stanford, CA 94305, USA., Huang Y; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US.; Biomedical Sciences Graduate Program, University of California, San Francisco, US.; Development and Stem Cell Biology Graduate Program, University of California, San Francisco, US.; Department of Neurology, University of California, San Francisco, CA, USA., Wyss-Coray T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 25. Date of Electronic Publication: 2023 Jul 25.

Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17.

Autor: Iram T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. tal.iram@stanford.edu.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA. tal.iram@stanford.edu., Kern F; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.; Department of Clinical Bioinformatics, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Saarland University Campus, Saarbrücken, Germany., Kaur A; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA., Myneni S; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA., Morningstar AR; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA., Shin H; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA., Garcia MA; Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, CA, USA., Yerra L; Palo Alto Veterans Institute for Research, Palo Alto, CA, USA., Palovics R; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA., Yang AC; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA., Hahn O; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA., Lu N; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA., Shuken SR; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA.; Department of Chemistry, Stanford University, Stanford, CA, USA., Haney MS; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA., Lehallier B; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA., Iyer M; Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, CA, USA., Luo J; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Palo Alto Veterans Institute for Research, Palo Alto, CA, USA., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; UK Dementia Research Institute at UCL, London, UK., Keller A; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.; Department of Clinical Bioinformatics, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Saarland University Campus, Saarbrücken, Germany.; Center for Bioinformatics, Saarland Informatics Campus, Saarbrücken, Germany., Zuchero JB; Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, CA, USA., Wyss-Coray T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. twc@stanford.edu.; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA. twc@stanford.edu.; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA, USA. twc@stanford.edu.

Publikováno v: Nature [Nature] 2022 May; Vol. 605 (7910), pp. 509-515. Date of Electronic Publication: 2022 May 11.

The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C.

Autor: Pluvinage JV; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA., Sun J; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA., Claes C; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA., Flynn RA; Stem Cell Program, Children's Hospital Boston, Boston, MA 02115, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Haney MS; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA., Iram T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA., Meng X; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA., Lindemann R; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA., Riley NM; Department of Chemistry and ChEM-H, Stanford University, Stanford, CA 94305, USA.; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94304, USA., Danhash E; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA., Chadarevian JP; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA., Tapp E; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA., Gate D; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA., Kondapavulur S; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA 94143, USA., Cobos I; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA., Chetty S; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Pașca AM; Division of Neonatology, Department of Pediatrics, Stanford University, Stanford, CA 94304, USA., Pașca SP; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA., Berry-Kravis E; Rush University Medical Center, Chicago, IL 60612, USA., Bertozzi CR; Department of Chemistry and ChEM-H, Stanford University, Stanford, CA 94305, USA.; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94304, USA., Blurton-Jones M; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA., Wyss-Coray T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94304, USA.; Wu Tsai Neurosciences Institute, Stanford, CA, 94305, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2021 Dec; Vol. 13 (622), pp. eabg2919. Date of Electronic Publication: 2021 Dec 01.