Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Handfield Robert Eugene"'
Autor:
Esmort Chisowa, Jade D. Nelson, Neil Choi, Zinka Brkic, Marcia A.-P. Lee, Brian P. Jones, Mark Olivier, Steven J. Brenek, Joe Desneves, Handfield Robert Eugene, Wayne Pearce, Michele T. Drexler, Jessica K. Watson, Stephane Caron, R. Matt Weekly, Mark P. Delude, G. C. A. Bellinger, Durgesh V. Nadkarni, Roberto Colon-Cruz
Publikováno v:
Organic Process Research & Development. 16:1338-1347
The research, development, and scale-up of the broad-spectrum antibacterial candidate sulopenem are presented. An enabled medicinal chemistry synthesis of this active pharmaceutical ingredient was utilized for Phase 1 and early Phase 2 manufacture bu
Autor:
Jade D. Nelson, Handfield Robert Eugene, Nathan D. Ide, Hahdi H. Perfect, Esmort Chisowa, Mark P. Delude, Marcus Ewing, Durgesh V. Nadkarni, R. Matt Weekly, Mark Olivier, John J. Teixeira, Steven J. Brenek, John P. Zelina, James E. Phillips, Michele T. Drexler, Stephane Caron
Publikováno v:
Organic Process Research & Development. 16:1348-1359
Previous synthetic processes for the preparation of sulopenem involved multistep linear sequences in which the chiral sulfoxide side chain was introduced early in the process. This contribution summarizes the development of a practical and convergent
Autor:
Chiara Bezze, Robert A. Singer, Megan McMahon, Mariano Stivanello, Gregory J. Withbroe, Handfield Robert Eugene, Paul E. Concannon, Jason D. McKinley, Timothy J. N. Watson, Lucia Leoni, Busch Frank R
Publikováno v:
Synthetic Communications. 38:441-447
Described here is the synthesis of (1‐(aminomethyl)‐2,3‐dihydro‐1H‐inden‐3‐yl)methanol 1, the previously unidentified impurity found in the synthesis of 2,1 providing a confirmation of the structure. Fabbrica Italiano Sintetici (FIS), w