Výsledky vyhledávání

Computational analysis of the mode of action of disopyramide and quinidine on hERG-linked short QT syndrome in human ventricles

Autor: Whittaker, DG, Ni, H, Benson, AP, Hancox, JC, Zhang, H

Publikováno v: Whittaker, D G, Ni, H, Benson, A P, Hancox, J C & Zhang, H 2017, ' Computational analysis of the mode of action of disopyramide and quinidine on hERG-linked short QT syndrome in human ventricles ', Frontiers in Physiology, vol. 8, 759 . https://doi.org/10.3389/fphys.2017.00759
Whittaker, D G, Ni, H, Benson, A P, Hancox, J C & Zhang, H 2017, ' Computational analysis of the mode of action of disopyramide and quinidine on heRG-linked short QT syndrome in human ventricles ', Frontiers in Physiology, vol. 8, no. OCT, 759 . https://doi.org/10.3389/fphys.2017.00759

The short QT syndrome (SQTS) is a rare cardiac disorder associated with arrhythmias and sudden death. Gain-of-function mutations to potassium channels mediating the rapid delayed rectifier current, IKr, underlie SQTS variant 1 (SQT1), in which treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9769ac342524ab2b12be549d6055c8b1
https://research-information.bris.ac.uk/en/publications/ab57d7b8-26e4-44bc-b504-7bfbe3ef13b2

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In silico investigation of a KCNQ1 mutation associated with short QT syndrome

Autor: Adeniran, I, Whittaker, DG, El Harchi, A, Hancox, JC, Zhang, H

Publikováno v: Adeniran, I, Whittaker, D, Harchi, A E, Hancox, J C & Zhang, H 2017, ' In silico investigation of a KCNQ1 mutation associated with short QT syndrome ', Scientific Reports . https://doi.org/10.1038/s41598-017-08367-2
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Adeniran, I, Whittaker, D G, El Harchi, A, Hancox, J C & Zhang, H 2017, ' In silico investigation of a KCNQ1 mutation associated with short QT syndrome ', Scientific Reports, vol. 7, 8469 . https://doi.org/10.1038/s41598-017-08367-2
Scientific Reports

Short QT syndrome (SQTS) is a rare condition characterized by abnormally ‘short’ QT intervals on the ECG and increased susceptibility to cardiac arrhythmias and sudden death. This simulation study investigated arrhythmia dynamics in multi-scale h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1e5d39b2f5feed3a98ed28b2ade750cd
https://www.research.manchester.ac.uk/portal/en/publications/in-silico-investigation-of-a-kcnq1-mutation-associated-with-short-qt-syndrome(667b12db-19c3-404c-b303-bf59dff716a6).html

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Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action: Mechanistic Insights from Canine Atrial Models

Autor: Varela, M, Colman, MA, Hancox, JC, Aslanidi, OV

Publikováno v: PLoS Computational Biology
Varela, M, Colman, M A, Hancox, J C & Aslanidi, O V 2016, ' Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action : Mechanistic Insights from Canine Atrial Models ', PLoS Computational Biology, vol. 12, no. 12, e1005245 . https://doi.org/10.1371/journal.pcbi.1005245
Varela, M, Colman, M A, Hancox, J C & Aslanidi, O 2016, ' Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action : Mechanistic Insights from Canine Atrial Models ', PLoS Computational Biology, vol. 12, no. 12, e1005245 . https://doi.org/10.1371/journal.pcbi.1005245
PLoS Computational Biology, Vol 12, Iss 12, p e1005245 (2016)

Anti-arrhythmic drug therapy is a frontline treatment for atrial fibrillation (AF), but its success rates are highly variable. This is due to incomplete understanding of the mechanisms of action of specific drugs on the atrial substrate at different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fd99922de819052f2162ebad1e36f21b
http://europepmc.org/articles/PMC5161306

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The Concise Guide to PHARMACOLOGY 2013/14: overview

Autor: Alexander, SP, Benson, HE, Faccenda, E, Pawson, AJ, Sharman, JL, McGrath, JC, Catterall, WA, Spedding, M, Peters, JA, Harmar, AJ, CGTP Collaborators, Abul-Hasn, N, Anderson, CM, Araiksinen, MS, Arita, M, Arthofer, E, Barker, EL, Barratt, C, Barnes, NM, Bathgate, R, Beart, PM, Belelli, D, Bennett, AJ, Birdsall, NJ, Boison, D, Bonner, TI, Brailsford, L, Bröer, S, Brown, P, Calo, G, Carter, WG, Chan, SL, Chao, MV, Chiang, N, Christopoulos, A, Chun, JJ, Cidlowski, J, Clapham, DE, Cockcroft, S, Connor, MA, Cox, HM, Cuthbert, A, Dautzenberg, FM, Davenport, AP, Dawson, PA, Dent, G, Dijksterhuis, JP, Dollery, CT, Dolphin, AC, Donowitz, M, Dubocovich, ML, Eiden, L, Eidne, K, Evans, BA, Fabbro, D, Fahlke, C, Farndale, R, Fitzgerald, GA, Fong, TM, Fowler, CJ, Fry, JR, Funk, CD, Futerman, AH, Ganapathy, V, Gaisnier, B, Gershengorn, MA, Goldin, A, Goldman, ID, Gundlach, AL, Hagenbuch, B, Hales, TG, Hammond, JR, Hamon, M, Hancox, JC, Hauger, RL, Hay, DL, Hobbs, AJ, Hollenberg, MD, Holliday, ND, Hoyer, D, Hynes, NA, Inui, KI, Ishii, S, Jacobson, KA, Jarvis, GE, Jarvis, MF, Jensen, R, Jones, CE, Jones, RL, Kaibuchi, K, Kanai, Y, Kennedy, C, Kerr, ID, Khan, AA, Klienz, MJ, Kukkonen, JP, Lapoint, JY, Leurs, R, Lingueglia, E, Lippiat, J, Lolait, SJ, Lummis, SC, Lynch, JW, MacEwan, D, Maguire, JJ, Marshall, IL, May, JM, McArdle, CA, Michel, MC, Millar, NS, Miller, LJ, Mitolo, V, Monk, PN, Moore, PK, Moorhouse, AJ, Mouillac, B, Murphy, PM, Neubig, RR, Neumaier, J, Niesler, B, Obaidat, A, Offermanns, S, Ohlstein, E, Panaro, MA, Parsons, S, Pwrtwee, RG, Petersen, J, Pin, JP, Poyner, DR, Prigent, S, Prossnitz, ER, Pyne, NJ, Pyne, S, Quigley, JG, Ramachandran, R, Richelson, EL, Roberts, RE, Roskoski, R, Ross, RA, Roth, M, Rudnick, G, Ryan, RM, Said, SI, Schild, L, Sanger, GJ, Scholich, K, Schousboe, A, Schulte, G, Schulz, S, Serhan, CN, Sexton, PM, Sibley, DR, Siegel, JM, Singh, G, Sitsapesan, R, Smart, TG, Smith, DM, Soga, T, Stahl, A, Stewart, G, Stoddart, LA, Summers, RJ, Thorens, B, Thwaites, DT, Toll, L, Traynor, JR, Usdin, TB, Vandenberg, RJ, Villalon, C, Vore, M, Waldman, SA, Ward, DT, Willars, GB, Wonnacott, SJ, Wright, E, Ye, RD, Yonezawa, A, Zimmermann, M

Publikováno v: British Journal of Pharmacology

The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::85ff08f7606079712eaab876e122a039

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Akademický článek

Cardiac ion channel modulation by the hypoglycaemic agent rosiglitazone.

Autor: Hancox, JC¹, Hancox, J C² (AUTHOR)

Publikováno v: British Journal of Pharmacology. Jun2011, Vol. 163 Issue 3, p496-498. 3p.

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