Výsledky vyhledávání

Identification and validation of DOCK4 as a potential biomarker for risk of bone metastasis development in patients with early breast cancer

Autor: Westbrook, JA, Wood, SL, Cairns, DA, McMahon, K, Gahlaut, R, Thygesen, H, Shires, M, Roberts, S, Marshall, H, Oliva, MR, Dunning, MJ, Hanby, AM, Selby, PJ, Speirs, V, Mavria, G, Coleman, RE, Brown, JE

Publikováno v: The Journal of Pathology
Cancer Informatics

Skeletal metastasis occurs in around 75% of advanced breast cancers, with the disease incurable once cancer cells disseminate to bone, but there remains an unmet need for biomarkers to identify patients at high risk of bone recurrence. This study aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ae049024cb6d0334901100f6d4ba9980
http://europepmc.org/articles/PMC6618075

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Levels of different subtypes of tumour-infiltrating lymphocytes correlate with each other, with matched circulating lymphocytes, and with survival in breast cancer

Autor: Verma, R, Hanby, AM, Horgan, K, Verghese, ET, Volpato, M, Carter, CR, Hughes, TA

Purpose: Breast cancer tumour-infiltrating lymphocytes associate with clinico-pathological factors, including survival, although the literature includes many conflicting findings. Our aim was to assess these associations for key lymphocyte subtypes a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::75be9c463d665ab538b0a00146505323

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Genomic and expression analyses define MUC17 and PCNX1 as predictors of chemotherapy response in breast cancer

Autor: Al Amri, WS, Allinson, LM, Baxter, DE, Bell, SM, Hanby, AM, Jones, SJ, Shaaban, AM, Stead, LF, Verghese, ET, Hughes, TA

Poor prognosis breast cancers are treated with cytotoxic chemotherapy, but often without any guidance from therapy predictive markers since universally-accepted markers are not currently available. Treatment failure, in the form of recurrences, is re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ce007c0b50a7017277c038e0b72cad01

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Stanniocalcin 2 expression is associated with a favourable outcome in male breast cancer

Autor: Coulson-Gilmer, C, Humphries, MP, Sundara Rajan, S, Droop, A, Jackson, S, Condon, A, Cserni, G, Jordan, LB, Jones, JL, Kanthan, R, Di Benedetto, A, Mottolese, M, Provenzano, E, Kulka, J, Shaaban, AM, Hanby, AM, Speirs, V

Publikováno v: The Journal of Pathology: Clinical Research
Coulson-Gilmer, C, Humphries, M P, Sundara Rajan, S, Droop, A, Jackson, S, Condon, A, Cserni, G, Jordan, L B, Jones, L J, Kanthan, R, Di Benedetto, A, Mottolese, M, Provenzano, E, Kulka, J, Shaaban, A M, Hanby, A M & Speirs, V 2018, ' Stanniocalcin 2 expression is associated with a favourable outcome in male breast cancer ', The Journal of Pathology: Clinical Research, vol. 4, no. 4, pp. 241-249 . https://doi.org/10.1002/cjp2.106

Breast cancer can occur in either gender; however, it is rare in men, accounting for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::44e322fed022c5c8ccb9175cfee86df7
http://europepmc.org/articles/PMC6174618

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The BIG 2.04 MRC/EORTC SUPREMO Trial: pathology quality assurance of a large phase 3 randomised international clinical trial of postmastectomy radiotherapy in intermediate-risk breast cancer

Autor: Thomas, JS, Hanby, AM, Russell, N, van Tienhoven, G, Riddle, K, Anderson, N, Cameron, DA, Bartlett, JMS, Piper, T, Cunningham, C, Canney, P, Kunkler, IH, On, BOTSTMG

Introduction SUPREMO is a phase 3 randomised trial evaluating radiotherapy post-mastectomy for intermediate-risk breast cancer. 1688 patients were enrolled from 16 countries between 2006 and 2013. We report the results of central pathology review car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::7621a4cbc477d1b3ae98db93d2b3bbc4

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MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion

Autor: Verghese, ET, Drury, R, Green, CA, Holliday, DL, Lu, X, Nash, C, Speirs, V, Thorne, JL, Thygesen, HH, Zougman, A, Hull, MA, Hanby, AM, Hughes, TA

Publikováno v: The Journal of Pathology

Carcinoma‐associated fibroblasts (CAFs) influence the behaviour of cancer cells but the roles of microRNAs in this interaction are unknown. We report microRNAs that are differentially expressed between breast normal fibroblasts and CAFs of oestroge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e5a00125dd05d087f6288d5b0e1b6565
http://europepmc.org/articles/PMC4030585

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Beta-catenin abnormalities and associated insulin-like growth factor overexpression are important in phyllodes tumours and fibroadenomas of the breast

Autor: Sawyer, EJ, Hanby, AM, Poulsom, R, Jeffery, R, Gillett, CE, Ellis, IO, Ellis, P, Tomlinson, IP

The aim of this study was to assess the expression of IGF-I and IGF-II in phyllodes tumours and fibroadenomas and to see if there is any correlation between nuclear beta-catenin expression and IGF-I and IGF-II expression in these tumours. In a previo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::629cc0684b82f137d790ec95ef56db3f
https://ora.ox.ac.uk/objects/uuid:bbd36319-de2e-4012-8f59-aa783e592a76

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A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence

Autor: Jones, AM, Mitter, R, Springall, R, Graham, T, Winter, E, Gillett, C, Hanby, AM, Tomlinson, IP, Sawyer, EJ

The aims of this study were to identify genetic changes associated with malignant progression of the fibroepithelial neoplasms, phyllodes tumours of the breast (PTs), and to ascertain whether genetic progression occurs when PTs recur locally. A furth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bf9ef9abc369239bcb13ec0652925df7
https://ora.ox.ac.uk/objects/uuid:83309d5a-6efa-4ad1-a4f7-a0e3b7f57b47

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High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers

Autor: Fredersdorf, S, Burns, J, Milne, AM, Packham, G, Fallis, L, Gillett, CE, Royds, JA, Peston, D, Hall, PA, Hanby, AM, Barnes, DM, Shousha, S, O'Hare, MJ, Lu, X

The expression of cyclin-dependent kinase inhibitor p27(kip1) in human tumors and normal tissues was investigated using a panel of novel anti-p27(kip1) mAbs. An inverse correlation between expression of p27(kip1) and cell proliferation was generally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::85514317da84a2d0f946f0188d56dc1e
https://doi.org/10.1073/pnas.94.12.6380

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Expression of phosphorylated eIF4E-binding protein 1, but not of eIF4E itself, predicts survival in male breast cancer

Autor: Millican-Slater, RA, Sayers, CD, Hanby, AM, Hughes, TA

Background: Male breast cancer is rare and treatment is based on data from females. High expression/activity of eukaryotic initiation factor 4E (eIF4E) denotes a poor prognosis in female breast cancer, and the eIF4E pathway has been targeted therapeu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::c77da2ed8ebfc7c377d7fb8f7913e8da

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