Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Hanbiao Yang"'
Autor:
Paul M. Wehn, Song Yang, Jonas A. Grina, James P. Rizzi, Stephen T. Schlachter, Bin Wang, Rui Xu, Hanbiao Yang, Xinlin Du, Guangzhou Han, Keshi Wang, Robert M. Czerwinski, Emily L. Ged, Heli Huang, Megan M. Halfmann, Melissa A. Maddie, Emily R. Morton, Sarah R. Olive, Huiling Tan, Shanhai Xie, John A. Josey, Eli M. Wallace
Pharmacokinetic properties of our first-generation HIF-2α antagonist PT2385, including modest solubility, resulted in a high recommended phase 2 dose (RP2D) of 800 mg BID and motivated the pursuit of novel scaffolds which could improve solubility an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df873b27c3e83d093d39f5958023934e
https://doi.org/10.21203/rs.3.rs-2753648/v1
https://doi.org/10.21203/rs.3.rs-2753648/v1
Autor:
John A. Josey, Hanbiao Yang, Rui Xu, Shanhai Xie, Keshi Wang, Bin Wang, Huiling Tan, Stephen T. Schlachter, Sarah R. Olive, Melissa A. Maddie, Megan M. Halfmann, Jonas A. Grina, Barry S. Goggin, Darryl D. Dixon, Robert M. Czerwinski, Tzuling Cheng, Xinlin Du, Zhaodan Cao, Paul M. Wehn, Guangzhou Han, James P. Rizzi, Eli M. Wallace
Supplementary method includes detailed experimental procedure for the synthesis of PT2385. Supplementary Figures 1-7 - Lack of cytotoxicity of PT2385 in cultured 786-O and A498 cells (1); PT2385 pharmacokinetics in CD-1 mice (2); Inhibition of HIF-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ba58b87702663a6c4d7ea731902dd9
https://doi.org/10.1158/0008-5472.22411674.v1
https://doi.org/10.1158/0008-5472.22411674.v1
Autor:
John A. Josey, Hanbiao Yang, Rui Xu, Shanhai Xie, Keshi Wang, Bin Wang, Huiling Tan, Stephen T. Schlachter, Sarah R. Olive, Melissa A. Maddie, Megan M. Halfmann, Jonas A. Grina, Barry S. Goggin, Darryl D. Dixon, Robert M. Czerwinski, Tzuling Cheng, Xinlin Du, Zhaodan Cao, Paul M. Wehn, Guangzhou Han, James P. Rizzi, Eli M. Wallace
More than 90% of clear cell renal cell carcinomas (ccRCC) exhibit inactivation of the von Hippel–Lindau (pVHL) tumor suppressor, establishing it as the major underlying cause of this malignancy. pVHL inactivation results in stabilization of the hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cb681633f0b5416aa695f9339844dfb
https://doi.org/10.1158/0008-5472.c.6508272.v1
https://doi.org/10.1158/0008-5472.c.6508272.v1
Publikováno v:
Fuzzy Sets and Systems. 425:1-17
A fuzzy compactum in a space X is an upper semi-continuous map f : A → [ 0 , 1 ] from a nonempty compact subspace A ⊂ X to the unit closed interval [ 0 , 1 ] such that { x ∈ A : f ( x ) > 0 } is dense in A. In this paper, we investigate the top
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00476bab8316416420e0d533742cf670
https://doi.org/10.1016/j.fss.2020.09.008
https://doi.org/10.1016/j.fss.2020.09.008
Publikováno v:
Topology and its Applications. 333:108474
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c70e363842d38ce0075680f0bce4ce4
https://doi.org/10.1016/j.topol.2023.108474
https://doi.org/10.1016/j.topol.2023.108474
Autor:
Hanbiao Yang, Daocheng Zeng
Publikováno v:
Journal of Intelligent & Fuzzy Systems. 38:1855-1864
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33104ad164cff95035fb48f857c0dd55
https://doi.org/10.3233/jifs-190272
https://doi.org/10.3233/jifs-190272
Autor:
James P. Rizzi, Xinlin Du, John A. Josey, Eli M. Wallace, Robert M. Czerwinski, Guangzhou Han, Rui Xu, Hanbiao Yang, Tai Wong, Shanhai Xie, Jonas Grina, Paul M. Wehn, Darryl D. Dixon, Stephen T. Schlachter, Emily L Ged, Keshi Wang, Heli Huang, Huiling Tan, Bin Wang
Publikováno v:
Journal of Medicinal Chemistry. 62:6876-6893
The hypoxia-inducible factor 2α (HIF-2α) is a key oncogenic driver in clear cell renal cell carcinoma (ccRCC). Our first HIF-2α inhibitor PT2385 demonstrated promising proof of concept clinical activity in heavily pretreated advanced ccRCC patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b0ccbb708d114033b81f48d69ed5cb7
https://doi.org/10.1021/acs.jmedchem.9b00719
https://doi.org/10.1021/acs.jmedchem.9b00719
Autor:
John A. Josey, Zhaodan Cao, Tai Wong, Megan M. Halfmann, Heli Huang, Barry Goggin, Robert M. Czerwinski, Hanbiao Yang, Paul M. Wehn, Bin Wang, Shanhai Xie, Sarah R. Olive, Huiling Tan, Eli M. Wallace, Darryl D. Dixon, Melissa A. Maddie, Xinlin Du, Rui Xu, Stephen T. Schlachter, James P. Rizzi, Emily L. Morton, Tzuling Cheng, Jonas Grina, Keshi Wang, Guangzhou Han
Publikováno v:
Journal of Medicinal Chemistry. 61:9691-9721
HIF-2α, a member of the HIF family of transcription factors, is a key oncogenic driver in cancers such as clear cell renal cell carcinoma (ccRCC). A signature feature of these cancers is the overaccumulation of HIF-2α protein, often by inactivation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bf4fbb16ea14332bdd9c2e58a806b92
https://doi.org/10.1021/acs.jmedchem.8b01196
https://doi.org/10.1021/acs.jmedchem.8b01196
Publikováno v:
Topology and its Applications. 301:107517
In this paper, we characterize stratifiable (or semi-stratifiable) spaces, and monotonically countably paracompact (or monotonically countably metacompact) spaces by expansions of locally upper bounded semi-continuous poset-valued maps. These extend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df531551e30d7432eaef395a41e9bfcd
https://doi.org/10.1016/j.topol.2020.107517
https://doi.org/10.1016/j.topol.2020.107517
Publikováno v:
Topology and its Applications. 301:107543
For a finite tree T and its endpoint v, we can define a natural partial order ≤ such that v is the greatest element in T. For a compact metric space X and a continuous map f : X → T , let ↓ f = { ( x , t ) : t ≤ f ( x ) } and ↓ C ( X , T )
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03d182c6d4017369d0835e73682f7ae9
https://doi.org/10.1016/j.topol.2020.107543
https://doi.org/10.1016/j.topol.2020.107543