Protocol to induce and assess cGAS-STING pathway activation in vitro

Autor: Hanane Chamma, Soumyabrata Guha, Nadine Laguette, Isabelle K. Vila

Publikováno v: STAR Protocols, Vol 3, Iss 2, Pp 101384- (2022)

Summary: The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays a pivotal role in several cellular processes including pathogen recognition and inflammatory responses. We describe a protocol to activate the cGAS-STING

Externí odkaz: https://doaj.org/article/ef12246d369b4bd4b372fcb30ebafb28

DNA damage repair kinase DNA‐PK and cGAS synergize to induce cancer‐related inflammation in glioblastoma

Autor: Clara Taffoni, Johanna Marines, Hanane Chamma, Soumyabrata Guha, Mathilde Saccas, Amel Bouzid, Ana‐Luiza Chaves Valadao, Clément Maghe, Jane Jardine, Mi Kyung Park, Katarzyna Polak, Mara De Martino, Claire Vanpouille‐Box, Maguy Del Rio, Celine Gongora, Julie Gavard, Nicolas Bidère, Min Sup Song, Donovan Pineau, Jean‐Philippe Hugnot, Karima Kissa, Laura Fontenille, Fabien P Blanchet, Isabelle K Vila, Nadine Laguette

Publikováno v: EMBO Journal
EMBO Journal, 2023, 42 (7), pp.e111961. ⟨10.15252/embj.2022111961⟩

International audience; Cytosolic DNA promotes inflammatory responses upon detection by the cyclic GMP-AMP (cGAMP) synthase (cGAS). It has been suggested that cGAS downregulation is an immune escape strategy harnessed by tumor cells. Here, we used gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca26b903f9efbbb31d2dc98e01baca2
https://doi.org/10.15252/embj.2022111961

Activation of STING in the pancreatic tumor microenvironment: a novel therapeutic opportunity

Autor: Hanane Chamma, Isabelle K. Vila, Clara Taffoni, Andrei Turtoi, Nadine Laguette

Publikováno v: Cancer Letters
Cancer Letters, 2022, 538, pp.215694. ⟨10.1016/j.canlet.2022.215694⟩

International audience; Pancreatic ductal adenocarcinoma (PDAC) is a cancer of poor prognosis that presents with a dense desmoplastic stroma that contributes to therapeutic failure. PDAC patients are mostly unresponsive to immunotherapy. However, hop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076820aa149ef9b08f7d54d57843c29d
https://hal.science/hal-03668657/document

STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

Autor: Isabelle K. Vila, Hanane Chamma, Alizée Steer, Mathilde Saccas, Clara Taffoni, Evgenia Turtoi, Line S. Reinert, Saqib Hussain, Johanna Marines, Lei Jin, Xavier Bonnefont, Mathieu Hubert, Olivier Schwartz, Soren R. Paludan, Gaetan Van Simaeys, Gilles Doumont, Bijan Sobhian, Dimitrios Vlachakis, Andrei Turtoi, Nadine Laguette

Publikováno v: Cell Metabolism
Cell Metabolism, 2022, 34 (1), pp.125-139.e8. ⟨10.1016/j.cmet.2021.12.007⟩
Vila, I K, Chamma, H, Steer, A, Saccas, M, Taffoni, C, Turtoi, E, Reinert, L S, Hussain, S, Marines, J, Jin, L, Bonnefont, X, Hubert, M, Schwartz, O, Paludan, S R, Van Simaeys, G, Doumont, G, Sobhian, B, Vlachakis, D, Turtoi, A & Laguette, N 2022, ' STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses ', Cell Metabolism, vol. 34, no. 1, pp. 125-139.e8 . https://doi.org/10.1016/j.cmet.2021.12.007
Cell Metabolism, Elsevier, 2022, 34 (1), pp.125-139.e8. ⟨10.1016/j.cmet.2021.12.007⟩

Summary Concerted alteration of immune and metabolic homeostasis underlies several inflammation-related pathologies, ranging from metabolic syndrome to infectious diseases. Here, we explored the coordination of nucleic acid-dependent inflammatory res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf4272494abb034b39c4311bc04b74d
https://doi.org/10.1016/j.cmet.2021.12.007