Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Hanan S El-Abhar"'
Publikováno v:
JGH Open, Vol 3, Iss 4, Pp 281-289 (2019)
Background Inflammatory bowel diseases are immunologically mediated disorders of gastrointestinal tract, characterized by dysregulated immune responses that result in a chronic intestinal inflammation. The antiplatelet cilostazol (CS), a phosphodiest
Externí odkaz:
https://doaj.org/article/9cb5c21bdbb54a6786f4dacd11eae5f7
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Background Hepatic hypoxia/reoxygenation (H/R) insult is a critical issue in hepatic transplant and surgeries, profoundly influencing postoperative prognosis. One crucial pathomechanism in this condition is impaired autophagy flux, which dis
Externí odkaz:
https://doaj.org/article/b51556b500f64643b75e413fe81e6e17
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134648 (2015)
The cholinergic anti-inflammatory pathway is one of the putative biochemical pathways that link diabetes with Alzheimer disease. Hence, we aimed to verify the potential antidiabetic effect of galantamine, unveil the possible mechanisms and evaluate i
Externí odkaz:
https://doaj.org/article/2a48a1503ec14505b45aaf95108d252c
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e95313 (2014)
Cilostazol, a phosphodiesterase-III inhibitor, reportedly exhibits positive effects against ischemia/reperfusion (I/R)-induced injury in several models. However, its potential role against the renal I/R insult has not been elucidated. To test whether
Externí odkaz:
https://doaj.org/article/7ce15cebed7a46c4b9ddb9830ed9762a
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89169 (2014)
As a nutritional supplement, coenzyme Q10 (CoQ10) was tested previously in several models of diabetes and/or insulin resistance (IR); however, its exact mechanisms have not been profoundly explicated. Hence, the objective of this work is to verify so
Externí odkaz:
https://doaj.org/article/e78af07bf4a949218974e820598b638d
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e45638 (2013)
Since activation of PPARγ is the main target for the antidiabetic effect of TZDs, especially when it heterodimerizes with RXR, we aimed to test the potential antidiabetic effect of phytol (250 mg/kg), the natural precursor of phytanic acid, a RXR li
Externí odkaz:
https://doaj.org/article/81e7b34aaba04d0bb2ed63b28eaaed8a
Autor:
Hanan S El-Abhar, Mona F Schaalan
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37757 (2012)
Topiramate is an antiepileptic drug known to ameliorate insulin resistance besides reducing body weight. Albeit liver plays a fundamental role in regulation of overall insulin resistance, yet the effect of topiramate on this organ is controversial an
Externí odkaz:
https://doaj.org/article/971a8f979318476aa35cde700e2066ab
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Endocannabinoid anandamide (AEA) has a physiological role in regulating renal blood flow, whereas its analogs ameliorated renal ischemia/reperfusion injury. Nonetheless, the role of AEA against mercuric chloride (HgCl2)-induced renal toxicit
Externí odkaz:
https://doaj.org/article/ce0c7ba427064a678b6c65fa8820b9d8
Publikováno v:
Saudi Pharmaceutical Journal, Vol 31, Iss 11, Pp 101818- (2023)
The potential health benefits of phytochemicals in preventing and treating diseases have gained increasing attention. Here, we proved that the methylated isoflavone prunetin possesses a reno-therapeutic effect against renal ischemia/reperfusion (I/R)
Externí odkaz:
https://doaj.org/article/c7071e38e6594eb1b3224f2656af771e
Autor:
Ayat I. Samra, Ahmed S. Kamel, Dalaal M. Abdallah, Mai A. Abd El Fattah, Kawkab A. Ahmed, Hanan S. El-Abhar
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3156 (2023)
Autism spectrum disorder (ASD) prevalence is emerging with an unclear etiology, hindering effective therapeutic interventions. Recent studies suggest potential renin–angiotensin system (RAS) alterations in different neurological pathologies. Howeve
Externí odkaz:
https://doaj.org/article/c31eda68a3a7481d8ca966568adf0d01