Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Hanan H. Georgey"'
Autor:
Rania S. M. Ismail, Ahmed M. El Kerdawy, Dalia H. Soliman, Hanan H. Georgey, Nagwa M. Abdel Gawad, Andrea Angeli, Claudiu T. Supuran
Publikováno v:
BMC Chemistry, Vol 17, Iss 1, Pp 1-23 (2023)
Abstract An optimization strategy was adopted for designing and synthesizing new series of 2-oxindole conjugates. Selected compounds were evaluated for their antiproliferative effect in vitro against NCI-60 cell lines panel, inhibitory effect on carb
Externí odkaz:
https://doaj.org/article/521f95dcb807414ba9837f65d560d43a
Publikováno v:
Bulletin of Faculty of Pharmacy Cairo University, Vol 56, Iss 2, Pp 121-127 (2018)
Aurones, (Z)-2-benzylidenebenzofuran-3(2H)-ones, have proved to be promising bioactive compounds with a broad spectrum of activities including anticancer, antioxidant, antiparasitic and antibacterial activities. Aurones exhibited strong antiprolifera
Externí odkaz:
https://doaj.org/article/fe3c8c1d2ca04650b44153c5a08d7038
Publikováno v:
Bulletin of Faculty of Pharmacy Cairo University, Vol 51, Iss 2, Pp 273-282 (2013)
The synthesis of different series of 6-iodo-2-phenoxymethyl 3-substituted quinazolin-4(3H)-ones 5–17 is described. The structures of the newly synthesized compounds have been confirmed on the basis of elemental analyses, IR, 1H NMR and mass spectra
Externí odkaz:
https://doaj.org/article/39315a4d164c4f678f72f27f262c1f85
Autor:
Abdalla R. Mohamed, Ahmed Mostafa, Mahmoud A. El Hassab, Gomaa M. Hedeab, Sara H. Mahmoud, Riham F. George, Hanan H. Georgey, Nagwa M. Abdel Gawad, Mohamed K. El-Ashrey
Publikováno v:
RSC Medicinal Chemistry. 14:899-920
The expanded structure- and ligand-based drug design strategy was utilized to obtain a multitargeting SARS-CoV-2 inhibitor, compound 9a, with an IC50 value of 8.86 μM.
Autor:
Rehab H. Abd El-Aleam, Ahmed M. Sayed, Mostafa N. Taha, Riham F. George, Hanan H. Georgey, Hamdy M. Abdel-Rahman
Publikováno v:
Journal of Molecular Structure. 1277:134856
Autor:
Mohamed H. Younis, Eman R. Mohammed, Abdalla R. Mohamed, Marwa M. Abdel-Aziz, Hanan H. Georgey, Nagwa M. Abdel Gawad
Publikováno v:
Bioorganic chemistry. 124
In response to the urgent need to encounter infection diseases, and upon increasing concerns about the devastating effects of tuberculosis (TB), the promising thiazolidin-4-one scaffold was used as a starting point to design and synthesize seventeen
Autor:
Yomna I. El‐Gazzar, Heba R. Ghaiad, Ahmed M. El Kerdawy, Riham F. George, Hanan H. Georgey, Khairia M. Youssef, Hussein I. El‐Subbagh
Publikováno v:
Archiv der Pharmazie. 356:2200417
New 2-mercapto-quinazolin-4-one analogs were synthesized and tested for their in vitro anticancer activity, dihydrofolate reductase (DHFR) inhibition, and epidermal growth factor tyrosine kinase (EGFR-TK) inhibition activities. Compound 24, which is
Publikováno v:
European journal of medicinal chemistry. 228
Fluoroquinolones are a class of antibacterial agents used clinically to treat a wide array of bacterial infections. Although being potent, susceptibility to CNS side effects limits their use. It was observed that improvements in absorption, activity
Publikováno v:
RSC advances. 11(58)
Antibiotic resistance is one of the most important challenges of the 21st century. However, the growing understanding of bacterial pathogenesis and cell-to-cell communication has revealed many potential strategies for the discovery of drugs that can
Autor:
Walaa R. Mahmoud, Esraa Z. Mohammed, Hanan H. Georgey, Farghaly A. Omar, Riham F. George, Ghaneya S. Hassan
Publikováno v:
Bioorganic chemistry. 116
New diphenyl-1H-pyrazoles were synthesized and screened for CDK2 inhibition where 8d, 9b, 9c, and 9e exhibited promising activity (IC50 = 51.21, 41.36, 29.31, and 40.54 nM respectively) compared to R-Roscovitine (IC50 = 43.25 nM). Furthermore, prelim