Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Hanan El-Messmary"'
Autor:
Soad A.M. El-Hawash, Rasha A. Nassra, Mostafa M.M. El-Miligy, Hanan El-Messmary, Aly A. Hazzaa
Publikováno v:
Future medicinal chemistry. 9(5)
Aim: Simultaneous inhibition of 5-LOX/COX may enhance anti-inflammatory effects and reduce side effects. Hence, synthesis of novel dual inhibitors of 5-LOX/COX is an important strategy for treatment of inflammation. Results/methodology: The target co
Autor:
Mostafa M.M. El-Miligy, Soad A.M. El-Hawash, Aly A. Hazzaa, Hanan El-Messmary, Rasha A. Nassra
Publikováno v:
Bioorganic chemistry. 72
New molecular hybrids combining benzothiophene or its bioisostere benzofuran with rhodanine were synthesized as potential dual COX-2/5-LOX inhibitors. The benzothiophene or benzofuran scaffold was linked at position -2 with rhodanine which was furthe