Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Hanan A. Al-ghulikah"'
Autor:
Ibrahim H. Eissa, Hazem Elkady, Mahmoud Rashed, Alaa Elwan, Mohamed Hagras, Mohammed A. Dahab, Mohammed S. Taghour, Ibrahim M. Ibrahim, Dalal Z. Husein, Eslam B. Elkaeed, Hanan A. Al-ghulikah, Ahmed M. Metwaly, Hazem A. Mahdy
Publikováno v:
Heliyon, Vol 10, Iss 2, Pp e24005- (2024)
In this study, a series of seven novel 2,4-dioxothiazolidine derivatives with potential anticancer and VEGFR-2 inhibiting abilities were designed and synthesized as VEGFR-2 inhibitors. The synthesized compounds were tested in vitro for their potentia
Externí odkaz:
https://doaj.org/article/941a6ba96f1444fc9f1952738aba1c7c
Autor:
Samar El-Kalyoubi, Samiha A. El-Sebaey, A. M. Rashad, Hanan A. AL-Ghulikah, Mostafa M. Ghorab, Sherin M. Elfeky
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Novel series of aminopyrimidines bearing a biologically active cyclohexenone 3a–f and oxo-selaneylidene moiety 4, besides selenadiazolopyrimidines (5a–e and 7), were synthesised using 5,6-diaminouracils as starting materials. Compound 3a exhibite
Externí odkaz:
https://doaj.org/article/1df0066a07f24a0586d556a33458cb72
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
New thiazolopyrimidine derivatives 2, 3a-d, 4a-c, 5, 6a-c, and 7a,b were synthesised. All prepared compounds were evaluated by MTT cytotoxicity assay against three human tumour cell lines. Compounds 3c, 3d, 4c, 6a, 6b, and 7b exhibited potent to stro
Externí odkaz:
https://doaj.org/article/6844db220fd44e9b83ee585f52b77a0c
Autor:
Shoaib Khan, Shahid Iqbal, Wajid Rehman, Nadia Hussain, Rafaqat Hussain, Mazloom Shah, Farhan Ali, Ahmed M. Fouda, Yousaf Khan, Ayed A. Dera, Mohammed Issa Alahmdi, Ali Bahadur, Hanan A. Al-ghulikah, Eslam B. Elkaeed
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 7, Pp 104847- (2023)
Different research synthetic methods have been developed recently for the synthesis of bis-benzimidazole analogs to investigate various biological significances. In this present study, an attempt was made to synthesize a new series of bis-benzimidazo
Externí odkaz:
https://doaj.org/article/248bce0426604de2be53e71eb4fb0d96
Autor:
Samar El-Kalyoubi, Samiha A. El-Sebaey, Sherin M. Elfeky, Hanan A. AL-Ghulikah, Mona S. El-Zoghbi
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1303 (2023)
Structural-based drug design and solvent-free synthesis were combined to obtain three novel series of 5-arylethylidene-aminopyrimidine-2,4-diones (4, 5a–c, 6a,b), 5-arylethylidene-amino-2-thiopyrimidine-4-ones (7,8), and 6-arylpteridines (9,10) as
Externí odkaz:
https://doaj.org/article/a84624ebb1be4e469cd8a8848b2ea4a3
Autor:
Asma Sardar, Obaid-ur-Rahman Abid, Saima Daud, Basit Ali Shah, Wardah Shahid, Muhammad Ashraf, Mahvish Fatima, Safa Ezzine, Abdul Wadood, Azam Shareef, Hanan A. Al-Ghulikah, Siham A. Alissa
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 12, Pp 104300- (2022)
Inflammation is the immune system's adaptive response to tissue dysfunction or homeostatic imbalance, inducing fever, pain, physiological and biochemical changes via the cyclooxygenase (COX) and lipoxygenase (LOX) pathways. NSAIDs (non-steroidal anti
Externí odkaz:
https://doaj.org/article/5dc771bdeb1a4222b83e6a98883ffd42
Autor:
Farhat Jubeen, Sana Ijaz, Ishrat Jabeen, Usman Aftab, Wajeeha Mehdi, Awais Altaf, Siham A. Alissa, Hanan A. Al-Ghulikah, Safa Ezzine, Imen Bejaoui, Munawar Iqbal
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 12, Pp 104299- (2022)
In the present investigation, 5-Fluorouracil co-crystals with four cyclic dimers of amino acids (Glycine, Tryptophane, Leucine and Alanine conformers are prepared via co-crystallization route, with an aim to improve its anticancer effectiveness and t
Externí odkaz:
https://doaj.org/article/cd054f0255904df3a6b05a9f783c3ad7
Autor:
Rafaqat Hussain, Mazloom Shah, Shahid Iqbal, Wajid Rehman, Shoaib Khan, Liaqat Rasheed, Haseena Naz, Hanan A. Al-ghulikah, Eslam B. Elkaeed, Rami Adel Pashameah, Eman Alzahrani, Abd-ElAziem Farouk
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Twenty-five analogs were synthesized based on 1,3,4-thiadiazole-fused-[1,2,4]-thiadiazole incorporating 1,4-benzodioxine moiety (1–25) and then tested for the antidiabetic profile. The entire afforded derivatives showed varied inhibition profiles r
Externí odkaz:
https://doaj.org/article/035b96c7ad194d4a89aa48659fd557e8
Autor:
Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Ibraheem M. M. Gobaara, Hanan A. Al-ghulikah, Dalal Z. Husein, Ibrahim M. Ibrahim, Ahmed M. Metwaly, Ibrahim H. Eissa
Publikováno v:
Molecules, Vol 27, Iss 22, p 7719 (2022)
(E)-N-(3-(1-(2-(4-(2,2,2-Trifluoroacetamido)benzoyl)hydrazono)ethyl)phenyl)nicotinamide (compound 10) was designed as an antiangiogenic VEGFR-2 inhibitor with the essential pharmacophoric structural properties to interact with the catalytic pocket of
Externí odkaz:
https://doaj.org/article/8ffc0b98a2314df081995f65fd606add
Publikováno v:
Molecules, Vol 27, Iss 21, p 7485 (2022)
Two series of cyanopyrimidine hybrids were synthesized bearing either benzo[d]imidazole, benzo[d]oxazole, benzo[d]thiazole, and benzo[b]thiophene derivatives via methylene amino linker 3a–3d (Formula A) or various sulphonamide phenyl moieties 5a–
Externí odkaz:
https://doaj.org/article/1b981f6ae8844c80943fe76fc6ef46eb