Výsledky vyhledávání - "Hanako M, Reyes"

Zika virus employs the host antiviral RNase L protein to support replication factory assembly

Autor: Susan R. Weiss, Jillian N. Whelan, Hanako M. Reyes, Robert H. Silverman, Beihua Dong, Erick R. Perez, David M. Renner, Yize Li, Nicholas A. Parenti, Joshua Hatterschide

Publikováno v: Proc Natl Acad Sci U S A

Infection with the flavivirus Zika virus (ZIKV) can result in tissue tropism, disease outcome, and route of transmission distinct from those of other flaviviruses; therefore, we aimed to identify host machinery that exclusively promotes the ZIKV repl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ca6463210b85a72cae7cf6ca4c3ebc
https://pubmed.ncbi.nlm.nih.gov/34031250

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Activation of STING Signaling Pathway Effectively Blocks Human Coronavirus Infection

Autor: Jianxin You, Maria C. Basil, Edward E. Morrisey, Susan M. Lin, June F Yang, Jeremy Katzen, Susan R. Weiss, Wei Liu, Kathleen M. Stewart, Hanako M. Reyes, Yize Li

Publikováno v: J Virol

The COVID-19 pandemic poses a serious global health threat. The rapid global spread of SARS-CoV-2 highlights an urgent need to develop effective therapeutics for blocking SARS-CoV-2 infection and spread. Stimulator of Interferon Genes (STING) is a ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012a3ba42c04e685c1883a3f9619bddc
https://europepmc.org/articles/PMC8316077/

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Glucosidase inhibitors suppress SARS-CoV-2 in tissue culture and may potentiate

Autor: Pei Yong Shi, Tianlun Zhou, Timothy M. Block, Susan R. Weiss, Yanming Du, Hanako M. Reyes, Xuping Xie

Iminosugar glucosidase inhibitors prevent the folding of a range of viral N-linked glycoproteins, ranging from hepatitis B to Ebola. We recently showed they inhibit folding and function of the ACE2 protein, which is the receptor for SARS-CoV-2, and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d67e2050ab2b3d01e7d659702981289a
https://doi.org/10.1101/2021.05.14.444190

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SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance SARS-CoV-2 emergence in late 2019 led to the COVID-19 pandemic that has had devastating effects on human health and the economy. While early innate immune responses are essential for protection against virus invasion and inadequate respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71cc9bcddf2570733fa062fdd63dc7d
http://europepmc.org/articles/PMC8072330

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Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 In Vitro and SARS-CoV In Vivo

Autor: Susan R. Weiss, Krystal Matthews, Hanako M. Reyes, James Logue, Robert Haupt, Christopher M. Coleman, Stuart Weston, Yize Li, Matthew B. Frieman

Publikováno v: Journal of Virology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China at the end of 2019 and has rapidly caused a pandemic, with over 20 million recorded COVID-19 cases in August 2020 (https://covid19.who.int/). There are no FDA-approved anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21e92fad6d61c424ce3dcdf445a60c8
https://doi.org/10.1128/jvi.01218-20

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SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes

Publikováno v: bioRxiv

SummaryCoronaviruses are adept at evading host antiviral pathways induced by viral double-stranded RNA, including interferon (IFN) signaling, oligoadenylate synthetase–ribonuclease L (OAS-RNase L), and protein kinase R (PKR). While dysregulated or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109f491ca8c040dca6719c13c3137995
https://europepmc.org/articles/PMC7523129/

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Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2

Autor: Stuart, Weston, Christopher M, Coleman, Robert, Haupt, James, Logue, Krystal, Matthews, Yize, Li, Hanako M, Reyes, Susan R, Weiss, Matthew B, Frieman

Publikováno v: Journal of Virology

There are no FDA-approved antivirals for any coronavirus, including SARS-CoV-2. Numerous drugs are already approved for human use that may have antiviral activity and therefore could potentially be rapidly repurposed as antivirals. Here, we present d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::803d506d131cf928e21b419b0ada0b02
https://pubmed.ncbi.nlm.nih.gov/32817221

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