Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hanaka Mimura"'
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 51:119-127
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cda8a9e2d30b4e37f060644b02187574
https://doi.org/10.3999/jscpt.51.119
https://doi.org/10.3999/jscpt.51.119
A phase 1 multiple-ascending dose study of tirzepatide in Japanese participants with type 2 diabetes
Publikováno v:
Diabetes, obesitymetabolism. 24(2)
AIM To investigate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of tirzepatide in Japanese participants with type 2 diabetes (T2D). METHODS This phase 1, double-blind, placebo-controlled, parallel-dose, multiple-ascendin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ab55e905182a8d93aee2556482eea1
https://pubmed.ncbi.nlm.nih.gov/34647404
https://pubmed.ncbi.nlm.nih.gov/34647404
Publikováno v:
Diabetes. 68
Tirzepatide (TZP), a novel dual GIP and GLP-1 receptor agonist (RA), has shown superior glycemic control and weight loss compared to a selective GLP-1 RA. A Phase 1, double-blind, placebo-controlled, randomized, parallel-dose group, 8-week multiple a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9d584135bd44c1ff787c3e8c9a5d05d
https://doi.org/10.2337/db19-1024-p
https://doi.org/10.2337/db19-1024-p
Autor:
Kaoru Kobayashi, Hanaka Mimura, Masaya Hosoda, Yoko Ejiri, Mari Hashimoto, Kan Chiba, Linxiaoqing Xu
Publikováno v:
Drug Metabolism and Pharmacokinetics. 30:105-110
The expression of hepatic cytochrome P450 (CYP) enzymes is altered under pathological conditions with increased levels of cytokines. In this study, we analyzed the effects of cytokines (interleukin [IL]-1β, IL-6 and tumor necrosis factor α) on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14269ee61802325c01f73d901b50262b
https://doi.org/10.1016/j.dmpk.2014.09.004
https://doi.org/10.1016/j.dmpk.2014.09.004
Autor:
Yoko Ejiri, Kaoru Kobayashi, Hanaka Mimura, Kan Chiba, Masayuki Ishikawa, Hidenobu Oka, Eri Kajiwara, Masaya Hosoda
Publikováno v:
Drug metabolism and pharmacokinetics. 28(3)
Treatment with benzbromarone (BBR), a potent uricosuric drug, can be associated with liver injury. Recently, we reported that culture of human hepatocellular carcinoma FLC-4 cells on micro-space cell culture plates could increase the functional expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d38a7910f58cffac7f226876a46ef2c
https://pubmed.ncbi.nlm.nih.gov/23229783
https://pubmed.ncbi.nlm.nih.gov/23229783
Autor:
Hanaka Mimura, Sachiko Takagi, Yoko Ejiri, Kan Chiba, Akane Yoshida, Tomokazu Matsuura, Masaya Hosoda, Kaoru Kobayashi
Publikováno v:
Drug metabolism and pharmacokinetics. 27(5)
Human hepatocellular carcinoma cell lines cultured in a monolayer show negligible activities of drug-metabolizing enzymes such as cytochrome P450s (CYPs) and UDP-glucuronosyltransferases (UGTs). Here, we show that culture of human hepatocellular carc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fa63ff0fcc87fec8f9fb987950d2af
https://pubmed.ncbi.nlm.nih.gov/22447115
https://pubmed.ncbi.nlm.nih.gov/22447115