Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Hanaa Hariri"'
Autor:
Blessy Paul, Saroja Weeratunga, Vikas A. Tillu, Hanaa Hariri, W. Mike Henne, Brett M. Collins
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Recent advances in protein structure prediction using machine learning such as AlphaFold2 and RosettaFold presage a revolution in structural biology. Genome-wide predictions of protein structures are providing unprecedented insights into their archit
Externí odkaz:
https://doaj.org/article/b0c755485d2f403b8d0b3e36c808e9ef
Autor:
Mike F. Renne, Hanaa Hariri
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Cells prepare for fluctuations in nutrient availability by storing energy in the form of neutral lipids in organelles called Lipid Droplets (LDs). Upon starvation, fatty acids (FAs) released from LDs are trafficked to different cellular compartments
Externí odkaz:
https://doaj.org/article/0b64ff6273df467eba1a3f760b2e4ed3
Publikováno v:
eLife, Vol 10 (2021)
Eukaryotes compartmentalize metabolic pathways into sub-cellular domains, but the role of inter-organelle contacts in organizing metabolic reactions remains poorly understood. Here, we show that in response to acute glucose restriction (AGR) yeast un
Externí odkaz:
https://doaj.org/article/262d147dd4fb4639a758832d57cfaa57
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108446- (2020)
Summary: Isogenic cells manifest distinct cellular fates for a single stress; however, the nongenetic mechanisms driving such fates remain poorly understood. Here, we implement a robust multi-channel live-cell imaging approach to uncover noncanonical
Externí odkaz:
https://doaj.org/article/235f21ec70e14046ab6e3cb6ae5e1de8
Autor:
W. Mike Henne, Hanaa Hariri
Publikováno v:
Contact, Vol 1 (2018)
Lipid droplets (LDs) serve as specialized cytoplasmic organelles that harbor energy-rich lipids for long-term storage and may be mobilized as nutrient sources during extended starvation. How cells coordinate LD biogenesis and utilization in response
Externí odkaz:
https://doaj.org/article/f756660e000a410f9adf546652f806ba
Publikováno v:
Communicative & Integrative Biology, Vol 9, Iss 3 (2016)
Since their initial observation, contact sites formed between different organelles have transitioned from ignored curiosities to recognized centers for the exchange of metabolites and lipids. Contact formed between the ER and endomembrane system (eg.
Externí odkaz:
https://doaj.org/article/66d75a5098854d61b09a87c0b6a83513
Publikováno v:
ACS Chemical Biology. 17:1485-1494
Autor:
Kaitlyn M. Eckert, Jade Bowerman, Rupali Ugrankar, Hanaa Hariri, W. Mike Henne, Sanchari Datta, Gonçalo Vale, Jeffrey G. McDonald, Chase Corley
Publikováno v:
Proc Natl Acad Sci U S A
Fatty acids (FAs) are central cellular metabolites that contribute to lipid synthesis, and can be stored or harvested for metabolic energy. Dysregulation in FA processing and storage causes toxic FA accumulation or altered membrane compositions and c
Autor:
Hanaa Hariri, W. Mike Henne
Publikováno v:
Journal of Cell Biology. 221
SNX-RGS proteins are molecular tethers localized to multiple interorganelle contact sites that exhibit roles in cellular metabolism. Here, we highlight recent findings on these proteins and discuss their emerging roles in metabolism, human disease, a
Autor:
Blessy Paul, Saroja Weeratunga, Vikas A. Tillu, Hanaa Hariri, W. Mike Henne, Brett M. Collins
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
SummaryRecent advances in protein structure prediction using machine learning such as AlphaFold2 and RosettaFold presage a revolution in structural biology. Genome-wide predictions of protein structures are providing unprecedented insights into their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ab7d76e9ada6bd4a0cd01e9a22279e
https://doi.org/10.1101/2021.11.30.470681
https://doi.org/10.1101/2021.11.30.470681