Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hana Serban"'
Autor:
Pauline M. Rudd, Tama Endo, Cristina Colominas, Raymond A. Dwek, Stanley B. Prusiner, Susan F. Wheeler, Hana Serban, Mark R. Wormald, David Harvey, Darlene Groth, Akira Kobata
Publikováno v:
Proceedings of the National Academy of Sciences. 96:13044-13049
Prion protein consists of an ensemble of glycosylated variants or glycoforms. The enzymes that direct oligosaccharide processing, and hence control the glycan profile for any given glycoprotein, are often exquisitely sensitive to other events taking
Autor:
Thomas R. Appel, Dieter Kirsch, Oliver Schäfer, Hana Serban, Karin Post, Holger Wille, Ingrid Mehlhorn, Detlev Riesner, Martin Pitschke, Stanley B. Prusiner
Publikováno v:
bchm. 379:1307-1318
The N-terminally truncated form of the prion protein, PrP 27-30, and the corresponding recombinant protein, rPrP, were solubilized in 0.2% SDS, and the transitions induced by changing the conditions from 0.2% SDS to physiological conditions, i.e. rem
Autor:
David Peretz, Hana Serban, Dennis R. Burton, Stephen J. DeArmond, Nechama I. Smorodinsky, Stanley B. Prusiner, Ingrid Mehlhorn, R A Williamson, Raiza Bastidas
Publikováno v:
Proceedings of the National Academy of Sciences. 93:7279-7282
Prion diseases are disorders of protein conformation and do not provoke an immune response. Raising antibodies to the prion protein (PrP) has been difficult due to conservation of the PrP sequence and to inhibitory activity of alpha-PrP antibodies to
Autor:
Dallas Foster, Shu Lian Yang, Darlene Groth, Stephen J. DeArmond, Dennis Rapp, Marilyn Torchia, Michael R. Scott, Karen K. Hsiao, Hana Serban, Stanley B. Prusiner
Publikováno v:
Proceedings of the National Academy of Sciences. 91:9126-9130
Two lines of transgenic (Tg) mice expressing high (H) levels of the mutant P101L prion protein (PrP) developed a neurologic illness and central nervous system pathology indistinguishable from experimental murine scrapie; these mice were designated Tg
Autor:
Darlene Groth, Stanley B. Prusiner, Jiri G. Safar, Camille Deering, Jeff Monaghan, Haydn L. Ball, Michael R. Scott, Svetlana Didorenko, Laura Solforosi, Hana Serban, Dennis R. Burton, Julie Vergara, R. Anthony Williamson, Giuseppe Legname, Estelle Leclerc
There is increasing concern over the extent to which bovine spongiform encephalopathy (BSE) prions have been transmitted to humans, as a result of the rising number of variant Creutzfeldt-Jakob disease (vCJD) cases. Toward preventing new transmission
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d830eaf4df2f6103fad51a3b39eea5d7
http://hdl.handle.net/20.500.11767/16806
http://hdl.handle.net/20.500.11767/16806
Autor:
Oliver Schäfer, Eva Birkmann, Hana Serban, Katja Jansen, Stanley B. Prusiner, Karin Post, Detlev Riesner
Publikováno v:
Biological Chemistry. 382
The conversion of the alpha-helical, protease sensitive and noninfectious form of the prion protein (PrP(C)) into an insoluble, protease resistant, predominantly beta-sheeted and infectious form (PrP(Sc)) is the fundamental event in prion formation.
Autor:
Holger Wille, Jiri G. Safar, Fred E. Cohen, Darlene Groth, Stanley B. Prusiner, Hana Serban, Marilyn Torchia, Vincenza Itri
Publikováno v:
Nature medicine. 4(10)
Variations in prions, which cause different incubation times and deposition patterns of the prion protein isoform called PrP Sc , are often referred to as 'strains'. We report here a highly sensitive, conformation-dependent immunoassay that discrimin
Autor:
Stanley B. Prusiner, Darlene Groth, Holger Wille, Hana Serban, Martin Pitschke, Detlev Riesner, Michael A. Baldwin, Karin Post, K. Kellings
Publikováno v:
Prions and Brain Diseases in Animals and Humans ISBN: 9781489918987
Prions are composed largely, if not entirely, of an abnormal isoform of the prion protein (PrP) designated PrPSc. A protease resistant polypeptide, PrP 27–30, can be derived from PrPSc by limited proteolysis with retention of infectivity. Both PrPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b98ae9342573d6ae2e46a768a9fdc32
https://doi.org/10.1007/978-1-4899-1896-3_23
https://doi.org/10.1007/978-1-4899-1896-3_23
Autor:
Miklós Füzi, Krister Kristensson, Stanley B. Prusiner, Jean Marc Gabriel, Hana Serban, Stephen J. DeArmond, Michael Scott, John W. Wilesmith, Raymond Bradley, G. A. H. Wells, Dan Serban, Albert Taraboulos
Publikováno v:
The Journal of infectious diseases. 167(3)
Bovine spongiform encephalopathy (BSE) is a transmissible neurodegenerative disease. Six brain regions from 11 cattle were examined for the presence of the abnormal isoform of the prion protein (PrPBSE). The highest concentrations of PrPBSE were foun
Autor:
Yeganeh Zebarjadian, Stanley B. Prusiner, George A. Carlson, Dallas Foster, David Westaway, Michael R. Scott, Shu-Lian Yang, Carol Mirenda, Marilyn Torchia, Stephen J. DeArmond, Christine Ebeling, Hana Serban
Publikováno v:
Neuron. 7(1)
Prolonged incubation times for experimental scrapie in ILnJ mice are dictated by a dominant gene linked to the prion protein gene ( Prn-p ). Transgenic mice were analyzed to discriminate between an effect of the ILnJ Prn-p b allele and a distinct inc