Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Hana M Dobrovolny"'
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233031 (2020)
In order to determine correct dosage of chemotherapy drugs, the effect of the drug must be properly quantified. There are two important values that characterize the effect of the drug: εmax is the maximum possible effect of a drug, and IC50 is the d
Externí odkaz:
https://doaj.org/article/53505a8e35844914a08434ae3f9c0078
Autor:
Hana M Dobrovolny
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0236976 (2020)
SARS-CoV-2 started causing infections in humans in late 2019 and has spread rapidly around the world. While the number of symptomatically infected and severely ill people is high and has overwhelmed the medical systems of many countries, there is mou
Externí odkaz:
https://doaj.org/article/54cb94a18bf84534abe2b764f5de0020
A comparison of RSV and influenza in vitro kinetic parameters reveals differences in infecting time.
Autor:
Gilberto Gonzàlez-Parra, Filip De Ridder, Dymphy Huntjens, Dirk Roymans, Gabriela Ispas, Hana M Dobrovolny
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192645 (2018)
Influenza and respiratory syncytial virus (RSV) cause acute infections of the respiratory tract. Since the viruses both cause illnesses with similar symptoms, researchers often try to apply knowledge gleaned from study of one virus to the other virus
Externí odkaz:
https://doaj.org/article/b927870f2a4b43049fc16250aee81f64
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180582 (2017)
The emergence of influenza drug resistance has become of particular interest as current planning for an influenza pandemic involves using massive amounts of antiviral drugs. We use semi-stochastic simulations to examine the emergence of drug resistan
Externí odkaz:
https://doaj.org/article/282515ab2b764df7ba0118d7e374ed1b
Autor:
Lubna Pinky, Hana M Dobrovolny
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155589 (2016)
Studies have shown that simultaneous infection of the respiratory tract with at least two viruses is common in hospitalized patients, although it is not clear whether these infections are more or less severe than single virus infections. We use a mat
Externí odkaz:
https://doaj.org/article/91dad856664a48e1bb877f65b4889b42
Autor:
Hana M Dobrovolny, Micaela B Reddy, Mohamed A Kamal, Craig R Rayner, Catherine A A Beauchemin
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57088 (2013)
The role of the host immune response in determining the severity and duration of an influenza infection is still unclear. In order to identify severity factors and more accurately predict the course of an influenza infection within a human host, an u
Externí odkaz:
https://doaj.org/article/7006b585e28c4c2aaaac21d77b0e37d7
Autor:
Hana M Dobrovolny, Marc J Baron, Ronald Gieschke, Brian E Davies, Nelson L Jumbe, Catherine A A Beauchemin
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13811 (2010)
Several mechanisms have been proposed to account for the marked increase in severity of human infections with avian compared to human influenza strains, including increased cytokine expression, poor immune response, and differences in target cell rec
Externí odkaz:
https://doaj.org/article/4ce46c78807344fdb7682ba849b2ed55
Autor:
Zakarya Noffel, Hana M. Dobrovolny
Publikováno v:
Mathematical Biosciences and Engineering, Vol 20, Iss 7, Pp 12666-12681 (2023)
Defective viral genomes (DVGs) are viral genomes that contain only a partial viral RNA and so cannot replicate within cells on their own. If a cell containing DVGs is subsequently infected with a complete viral genome, the DVG can then use the missin
Externí odkaz:
https://doaj.org/article/23fdf89935fe499eb6a036d083112751
Autor:
Ela Guo, Hana M. Dobrovolny
Publikováno v:
Viruses, Vol 15, Iss 9, p 1812 (2023)
Oncolytic adenoviruses (OAds) present a promising path for cancer treatment due to their selectivity in infecting and lysing tumor cells and their ability to stimulate the immune response. In this study, we use an ordinary differential equation (ODE)
Externí odkaz:
https://doaj.org/article/8d2cd4ed9c7a43379d8a251eb87d20bb
Autor:
Ava Amidei, Hana M. Dobrovolny
Publikováno v:
Virology. 575
Several viruses have the ability to form large multinucleated cells known as syncytia. Many properties of syncytia and the role they play in the evolution of a viral infection are not well understood. One basic question that has not yet been answered