Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Hana Kubová"'
Publikováno v:
Epilepsia Open, Vol 8, Iss S1, Pp S90-S109 (2023)
Abstract Status epilepticus (SE) is the most common neurologic emergency in children. Both clinical and laboratory studies have demonstrated that SE in early life can cause brain damage and permanent behavioral abnormalities, trigger epileptogenesis,
Externí odkaz:
https://doaj.org/article/0df19a0c69fe450cabe69e9c30502075
Autor:
Pavel Mareš, Libor Uttl, Martina Laczó, Zina BenSalem, Kateřina Vondráková, Petr Fábera, Grygoriy Tsenov, Hana Kubová
Publikováno v:
Pharmaceuticals, Vol 16, Iss 12, p 1733 (2023)
Background: Postictal refractoriness, i.e., the inability to elicit a new epileptic seizure immediately after the first one, is present in mature animals. Immature rats did not exhibit this refractoriness, and it is replaced by postictal potentiation
Externí odkaz:
https://doaj.org/article/4c55e2e8965b484fbeeb9dc76f834db7
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2510 (2022)
LiCl/pilocarpine status epilepticus (SE) induced in immature rats leads, after a latent period, to hippocampal hyperexcitability. The excitability may be influenced by adenosine, which exhibits anticonvulsant activity. The concentration of adenosine
Externí odkaz:
https://doaj.org/article/897998de2ce64c15864f58df2c681804
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 94 (2021)
In spite of use of cannabidiol (CBD), a non-psychoactive cannabinoid, in pediatric patients with epilepsy, preclinical studies on its effects in immature animals are very limited. In the present study we investigated anti-seizure activity of CBD (10
Externí odkaz:
https://doaj.org/article/929674e428394d4599e9d7628ba69b75
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1482 (2021)
The GluN2B subunit of NMDA receptors represents a perspective therapeutic target in various CNS pathologies, including epilepsy. Because of its predominant expression in the immature brain, selective GluN2B antagonists are expected to be more effecti
Externí odkaz:
https://doaj.org/article/e3f59e41c636488aa51e4a0706d95700
Autor:
Hana Kubová, Zdenka Bendová, Simona Moravcová, Dominika Pačesová, Luisa Lilia Rocha, Pavel Mareš
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
γ-aminobutyric acid (GABA) pathways play an important role in neuronal circuitry formation during early postnatal development. Our previous studies revealed an increased risk for adverse neurodevelopmental consequences in animals exposed to benzodia
Externí odkaz:
https://doaj.org/article/5df2f1095c204e739a73ea7bc7f3b747
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3184 (2020)
Benzodiazepines (BZDs) are widely used in patients of all ages. Unlike adults, neonatal animals treated with BZDs exhibit a variety of behavioral deficits later in life; however, the mechanisms underlying these deficits are poorly understood. This st
Externí odkaz:
https://doaj.org/article/3e88a0aa090a40e2b5d9e65f1e0321db
Autor:
Hana Kubová, Jaroslava Folbergrová, Jana Rejchrtová, Grygoriy Tsenov, Martina Pařízková, James Burchfiel, Anna Mikulecká, Pavel Mareš
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Status epilepticus (SE), especially in immature animals, is known to produce recurrent spontaneous seizures and behavioral comorbidities later in life. The cause of these adverse long-term outcomes is unknown, but it has been hypothesized that free r
Externí odkaz:
https://doaj.org/article/d85ce7f0febe4b1b9952659777321d79
Autor:
Šárka Pospíšilová, Hana Kubová, Petra Bencurova, Jiri Baloun, Milan Brázdil, Jakub Hynšt, Jan Oppelt
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Temporal lobe epilepsy (TLE) is the most common epilepsy type. TLE onset in infancy aggravates features like severity, drug responsiveness, or development of comorbidities. These aggravations may arise from altered micro RNA (miRNA) expression specif
Publikováno v:
Epilepsia openREFERENCES.
Status epilepticus (SE) is the most common neurologic emergency in children. Both clinical and laboratory studies have demonstrated that SE in early life can cause brain damage and permanent behavioral abnormalities, trigger epileptogenesis, and inte