Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Hana Kostrhunova"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
AbstractSome metallo-supramolecular helical assemblies with size, shape, charge and amphipathic architectures similar to short cationic α-helical peptides have been shown to target and stabilise DNA G-quadruplexes (G4s) in vitro and downregulate the
Externí odkaz:
https://doaj.org/article/14b188dd04c0495880caaa130db1bc10
Autor:
Monika Hreusova, Vojtech Novohradsky, Lenka Markova, Hana Kostrhunova, Ivan Potočňák, Viktor Brabec, Jana Kasparkova
Publikováno v:
Bioinorganic Chemistry and Applications, Vol 2022 (2022)
In this work, gallium(III) complex with cloxyquin (5-chloro-8-quinolinol, HClQ) ligands is shown to effectively inhibit proliferation of rhabdomyosarcoma cells, the frequent, aggressive, and poorly treatable cancer of children. It offers striking sel
Externí odkaz:
https://doaj.org/article/9c53d497024647a2992bcd5d8fe8e554
Autor:
Jana Kasparkova, Hana Kostrhunova, Vojtech Novohradsky, Аlexey A. Logvinov, Viktor V. Temnov, Nataliya E. Borisova, Tatiana A. Podrugina, Lenka Markova, Pavel Starha, Alexey. A. Nazarov, Viktor Brabec
Publikováno v:
Bioinorganic Chemistry and Applications, Vol 2022 (2022)
One concept of improving anticancer effects of conventional platinum-based antitumor drugs consists of conjugating these compounds with other biologically (antitumor) active agents, acting by a different mechanism. Here, we present synthesis, physico
Externí odkaz:
https://doaj.org/article/3ca46adcbf094b3faac19d8bb49e9a33
Publikováno v:
Nucleic Acids Research
The design of efficient and safe gene delivery vehicles remains a major challenge for the application of gene therapy. Of the many reported gene delivery systems, metal complexes with high affinity for nucleic acids are emerging as an attractive opti
Publikováno v:
Inorganic Chemistry Frontiers. 9:5597-5606
Dinuclear nickel(ii) supramolecular helicates selectively stabilize DNA G-quadruplexes and suppress G-quadruplex-regulated genes.
Autor:
Vojtech Novohradsky, Lenka Markova, Hana Kostrhunova, Marie Svitelova, Jana Kasparkova, Alessandra Barbanente, Paride Papadia, Nicola Margiotta, James D. Hoeschele, Viktor Brabec
Publikováno v:
Inorganic Chemistry Frontiers. 9:3295-3305
Here, we investigated the mechanism of antiproliferative action in cancer cells of new compounds structurally derived from oxaliplatin, namely a pair of enantiomers [Pt(OXA)(1R,2R-DACHEX)] (1) and [Pt(OXA)(1S,2S-DACHEX)] (2) (OXA = oxalate, DACHEX =
Autor:
Ingo Ott, Valentina Gandin, Claudia Schmidt, Annika Timm, Viktor Brabec, Uttara Basu, Hana Kostrhunova, Dan Gibson, Tomer Babu
Publikováno v:
Journal of Medicinal Chemistry. 64:11364-11378
"Multi-action" Pt(IV) derivatives of cisplatin with combretastatin A4 (CA4) bioactive ligands that are conjugated to Pt(IV) by carbonate are unique because the ligand (IC50 < 10 nM) is dramatically 1000-folds more cytotoxic than cisplatin in vitro. T
Publikováno v:
Chemistry – A European Journal. 27:11682-11692
DNA G-quadruplexes (G4s) were identified within the promoter regions of many proto-oncogenes. Thus, G4s represent attractive targets for cancer therapy and the design and development of new drugs as G4 binders is a very active field of medicinal chem
Autor:
Jana Kasparkova, Hana Kostrhunova, Vojtech Novohradsky, Lili Ma, Guangyu Zhu, Elena R Milaeva, Alexender A Shtill, Robin Vinck, Gilles Gasser, Viktor Brabec, Alexey A Nazarov
Publikováno v:
Metallomics
Metallomics, Royal Society of Chemistry, 2022, ⟨10.1093/mtomcs/mfac048⟩
Metallomics, Royal Society of Chemistry, 2022, ⟨10.1093/mtomcs/mfac048⟩
This work studied the mechanism of action of a Pt(IV) complex 2 bearing two axial lonidamine ligands, which are selective inhibitors of aerobic glycolysis. The presence of two lonidamine ligands in 2 compared to the parent Pt(II) complex increased it
Autor:
Viktor Brabec, Natalia Cutillas, Hana Kostrhunova, Jana Kasparkova, Vojtech Novohradsky, José Ruiz, Gloria Vigueras, Alicia Marco, Lenka Markova
Publikováno v:
Inorganic Chemistry Frontiers. 8:4696-4711
Several anticancer chemotherapies, while eliminating the bulk of tumor cells, often fail, as they do not obliterate a small fraction of malignant cancer stem cells (CSCs). Thus, developing chemotherapeutics capable of targeting and abrogating CSCs, i