Výsledky vyhledávání - "Hana Kopecka"

Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction. Application to the synthesis of the antibacterial agent Dup-721

Autor: Daisy Pireh, Stevan W. Djuric, Richard J. Sciotti, David Madar, Paul E. Wiedeman, Marina A. Pliushchev, Jonathan Pease, Hana Kopecka

Publikováno v: Tetrahedron Letters. 42:3681-3684

A method for the intermolecular coupling of aryl bromides and oxazolidinones is described. Application to intermediates useful for the preparation of a known class of antibacterial agent and the synthesis of the known antibacterial oxazolidinone Dup-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8badd88a9d50772a71d9374962aca2c
https://doi.org/10.1016/s0040-4039(01)00559-7

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2-(Aryloxymethyl) azacyclic analogues as novel nicotinic acetylcholine receptor (nAChR) ligands

Autor: Nan-Horng Lin, Alyssa B. O'Neill, David J. Anderson, David S. Garvey, Richard L. Elliott, Michael W. Decker, Mark W. Holladay, James P. Sullivan, Michael J. Buckley, Karen L. Gunther, Stephen P. Arneric, David E. Gunn, Keith B. Ryther, Jeffrey E. Campbell, Hana Kopecka

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:2283-2288

A series of 2-(aryloxymethyl) azetidine and pyrrolidine nAChR ligands in which the 3-pyridyl moiety of a previously described series 1 was replaced by a substituted phenyl group was explored. Aromatic substitution afforded analogues with K i values r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be67a0c21a222990bd44ab06098c506c
https://doi.org/10.1016/0960-894x(96)00416-7

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Synthesis of [14C]ABT-418, a cholinergic channel activator labeled at two sites on the isoxazole ring

Autor: Hana Kopecka, Samuel Thomas, Bruce W. Surber, Richard L. Elliott

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 38:857-861

[ 14 C]ABT-418, (S)-3-[ 14 C]methyl-5-[N-methyl-2-pyrrolidinyl][4- 14 C]isoxazole hydrochloride, was labeled in two positions at maximum specific activity. Starting with 100 mCi of sodium [2 14 C]acetate, 14.6 mCi at 105 mCi/mmol was obtained in 8 st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56e20b8451900eba8fce5468356e61e5
https://doi.org/10.1002/(sici)1099-1344(199609)38:9<857::aid-jlcr897>3.0.co

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A short, efficient chiral synthesis of a novel cholinergic channel activator, ABT-418 [(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole], from (S)-pyroglutamic acid

Autor: Hana Kopecka, Yun He, Nan-Horng Lin

Publikováno v: Tetrahedron Letters. 36:2563-2566

ABT-418 [(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (1) is a cholinergic channel activator with potent congitive and anxiolytic activities in animal models. A three-pot synthesis of enantiomerically pure ABT-418 starting from commercially avai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff8008efc7b29fa10f63a92681564398
https://doi.org/10.1016/0040-4039(95)00340-i

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Double bond isosteres of the peptide bond: Synthesis and biological activity of cholecystokinin (CCK) C-terminal hexapeptide analogs

Autor: Sharon L. Kuyper, Alex M. Nadzan, Chun Wel Lin, Michael D. Tufano, Mike Stashko, Thomas R. Miller, Mark W. Holladay, Hana Kopecka, David G. Witte, Y.‐K. Shue, George M. Carrera

Publikováno v: Bioorganic & Medicinal Chemistry. 1:161-171

New and existing methodologies were used to prepare a series of modified CCK analogs in which each amide bond was replaced by a trans-alkene unit. The data indicate that every amide linkage at C-terminal tetrapeptide (CCK-4) region is crucial for bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed43732409febe53663b805ae77254d
https://doi.org/10.1016/s0968-0896(00)82117-3

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ChemInform Abstract: A Short, Efficient Chiral Synthesis of a Novel Cholinergic Channel Activator, ABT-418 ((S)-3-Methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole), from (S)-Pyroglutamic Acid

Autor: Yun He, Nan-Horng Lin, Hana Kopecka

Publikováno v: ChemInform. 26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fceba44f9c7e921c4b78ec79806442b3
https://doi.org/10.1002/chin.199532160

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ChemInform Abstract: Synthesis of N-Arylated Oxazolidinones via a Palladium-Catalyzed Cross-Coupling Reaction. Application to the Synthesis of the Antibacterial Agent Dup-721

Autor: Richard J. Sciotti, Marina A. Pliushchev, Paul E. Wiedeman, David Madar, Stevan W. Djuric, Jonathan Pease, Hana Kopecka, Daisy Pireh

Publikováno v: ChemInform. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bcb431092a413dacee04e55b7c1698f
https://doi.org/10.1002/chin.200136126

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Development of potent and selective CCK-A receptor agonists from Boc-CCK-4: tetrapeptides containing Lys(N.epsilon.)-amide residues

Autor: Bruce R. Bianchi, Kazumi Shiosaki, Chun Wel Lin, Alex M. Nadzan, Richard Craig, Thomas R. Miller, David G. Witte, Hana Kopecka, Michael A. Stashko

Publikováno v: Journal of Medicinal Chemistry. 35:2007-2014

A series of Boc-CCK-4 derivatives represented by the general structure Boc-Trp-Lys(N epsilon-COR)-Asp-Phe-NH2, where R is an aromatic, heterocyclic, or aliphatic group, are potent and selective CCK-A receptor agonists. These amide-bearing compounds c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1852cf206dea8921b0e14fbc215e8096
https://doi.org/10.1021/jm00089a010

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