Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Hana Imrichova"'
Autor:
Gang Xue, Jianing Xie, Matthias Hinterndorfer, Marko Cigler, Lara Dötsch, Hana Imrichova, Philipp Lampe, Xiufen Cheng, Soheila Rezaei Adariani, Georg E. Winter, Herbert Waldmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Targeted proteasomal and autophagic protein degradation, often employing bifunctional modalities, is a new paradigm for modulation of protein function. In an attempt to explore protein degradation by means of autophagy we combine arylidene-i
Externí odkaz:
https://doaj.org/article/8eb4dd1f4c7244f6a4e44f84f7729d66
Autor:
Zeynep Kalender Atak, Hana Imrichova, Dmitry Svetlichnyy, Gert Hulselmans, Valerie Christiaens, Joke Reumers, Hugo Ceulemans, Stein Aerts
Publikováno v:
Genome Medicine, Vol 9, Iss 1, Pp 1-13 (2017)
Abstract The identification of functional non-coding mutations is a key challenge in the field of genomics. Here we introduce μ-cisTarget to filter, annotate and prioritize cis-regulatory mutations based on their putative effect on the underlying
Externí odkaz:
https://doaj.org/article/16a8687e5b1941109d124dadcf0669a0
Autor:
Pavel Bouchal, Olga T. Schubert, Jakub Faktor, Lenka Capkova, Hana Imrichova, Karolina Zoufalova, Vendula Paralova, Roman Hrstka, Yansheng Liu, Holger Alexander Ebhardt, Eva Budinska, Rudolf Nenutil, Ruedi Aebersold
Publikováno v:
Cell Reports, Vol 28, Iss 3, Pp 832-843.e7 (2019)
Summary: Accurate classification of breast tumors is vital for patient management decisions and enables more precise cancer treatment. Here, we present a quantitative proteotyping approach based on sequential windowed acquisition of all theoretical f
Externí odkaz:
https://doaj.org/article/d8d0b79b7047470b9f630f406e4fb787
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 11, p e1004590 (2015)
Cancer genomes contain vast amounts of somatic mutations, many of which are passenger mutations not involved in oncogenesis. Whereas driver mutations in protein-coding genes can be distinguished from passenger mutations based on their recurrence, non
Externí odkaz:
https://doaj.org/article/11086cce95c6426f858f1a455260a575
Autor:
Patrick Laurette, Thomas Strub, Dana Koludrovic, Céline Keime, Stéphanie Le Gras, Hannah Seberg, Eric Van Otterloo, Hana Imrichova, Robert Siddaway, Stein Aerts, Robert A Cornell, Gabrielle Mengus, Irwin Davidson
Publikováno v:
eLife, Vol 4 (2015)
Microphthalmia-associated transcription factor (MITF) is the master regulator of the melanocyte lineage. To understand how MITF regulates transcription, we used tandem affinity purification and mass spectrometry to define a comprehensive MITF interac
Externí odkaz:
https://doaj.org/article/b685e02106604747b3e01f01e7b91f35
Autor:
Alexander Hanzl, Ryan Casement, Hana Imrichova, Scott J. Hughes, Eleonora Barone, Andrea Testa, Sophie Bauer, Jane Wright, Matthias Brand, Alessio Ciulli, Georg E. Winter
Publikováno v:
Nature Chemical Biology
Targeted protein degradation is a novel pharmacology established by drugs that recruit target proteins to E3 ubiquitin ligases. Based on the structure of the degrader and the target, different E3 interfaces are critically involved, thus forming defin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c1979c80def4fb682697dfbe784c69
https://doi.org/10.1038/s41589-022-01177-2
https://doi.org/10.1038/s41589-022-01177-2
Autor:
Marko Cigler, Hana Imrichova, Fabian Frommelt, Laura Depta, Andrea Rukavina, Chrysanthi Kagiou, J. Thomas Hannich, Cristina Mayor-Ruiz, Giulio Superti-Furga, Sonja Sievers, Luca Laraia, Herbert Waldmann, Georg E. Winter
Metabolic alterations in cancer precipitate in associated dependencies that can be therapeutically exploited. To meet this goal, natural product inspired small molecules can provide a resource of invaluable chemotypes. Here, we identify orpinolide, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80fe4d3822530f540a38153468b74d19
https://doi.org/10.1101/2023.03.15.532743
https://doi.org/10.1101/2023.03.15.532743
Autor:
Alexander Hanzl, Ryan Casement, Hana Imrichova, Scott J. Hughes, Eleonora Barone, Andrea Testa, Sophie Bauer, Jane Wright, Matthias Brand, Alessio Ciulli, Georg E. Winter
Targeted protein degradation is a new pharmacologic paradigm established by drugs that recruit target proteins to E3 ubiquitin ligases via a ternary ligase-degrader-target complex. Based on the structure of the degrader and the neosubstrate, differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a1e679debb999ebd75097eef0c196be
https://doi.org/10.1101/2022.04.14.488316
https://doi.org/10.1101/2022.04.14.488316
Autor:
Chin-Hsien Tsai, Yu-Ming Chuang, Xiaoyun Li, Yi-Ru Yu, Sheue-Fen Tzeng, Shao Thing Teoh, Katherine E. Lindblad, Mario Di Matteo, Wan-Chen Cheng, Pei-Chun Hsueh, Kung-Chi Kao, Hana Imrichova, Likun Duan, Hector Gallart-Ayala, Pei-Wen Hsiao, Massimiliano Mazzone, Julijana Ivanesevic, Xiaojing Liu, Karin E. de Visser, Amaia Lujambio, Sophia Y. Lunt, Susan M. Kaech, Ping-Chih Ho
Publikováno v:
Cell metabolism. 35(1)
Immunoediting sculpts immunogenicity and thwarts host anti-tumor responses in tumor cells during tumorigenesis; however, it remains unknown whether metabolic programming of tumor cells can be guided by immunosurveillance. Here, we report that T cell-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57204e4dab1941440a9ea9b50d1e7cc2
https://pubmed.ncbi.nlm.nih.gov/36599297
https://pubmed.ncbi.nlm.nih.gov/36599297
Autor:
Mark Petronczki, Stefan Kubicek, Nara C. Marella, Christoph Bock, André C. Müller, Jung-Ming G. Lin, Sarah Grosche, Danica Drpic, Gerald Hofstätter, Hana Imrichova, Anna Koren, Martin G. Jaeger, André F. Rendeiro, Michael Schuster, Sandra Schick, Georg E. Winter, Katharina Eva Kohl
Publikováno v:
Nature Genetics
Cancer-associated, loss-of-function mutations in genes encoding subunits of the BRG1/BRM-associated factor (BAF) chromatin-remodeling complexes1–8 often cause drastic chromatin accessibility changes, especially in important regulatory regions9–19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ca62813be8ca4a6654f5bf7c4a16b7