Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hana Imrichová"'
Autor:
Gang Xue, Jianing Xie, Matthias Hinterndorfer, Marko Cigler, Lara Dötsch, Hana Imrichova, Philipp Lampe, Xiufen Cheng, Soheila Rezaei Adariani, Georg E. Winter, Herbert Waldmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Targeted proteasomal and autophagic protein degradation, often employing bifunctional modalities, is a new paradigm for modulation of protein function. In an attempt to explore protein degradation by means of autophagy we combine arylidene-i
Externí odkaz:
https://doaj.org/article/8eb4dd1f4c7244f6a4e44f84f7729d66
Autor:
Zeynep Kalender Atak, Hana Imrichova, Dmitry Svetlichnyy, Gert Hulselmans, Valerie Christiaens, Joke Reumers, Hugo Ceulemans, Stein Aerts
Publikováno v:
Genome Medicine, Vol 9, Iss 1, Pp 1-13 (2017)
Abstract The identification of functional non-coding mutations is a key challenge in the field of genomics. Here we introduce μ-cisTarget to filter, annotate and prioritize cis-regulatory mutations based on their putative effect on the underlying
Externí odkaz:
https://doaj.org/article/16a8687e5b1941109d124dadcf0669a0
Autor:
Pavel Bouchal, Olga T. Schubert, Jakub Faktor, Lenka Capkova, Hana Imrichova, Karolina Zoufalova, Vendula Paralova, Roman Hrstka, Yansheng Liu, Holger Alexander Ebhardt, Eva Budinska, Rudolf Nenutil, Ruedi Aebersold
Publikováno v:
Cell Reports, Vol 28, Iss 3, Pp 832-843.e7 (2019)
Summary: Accurate classification of breast tumors is vital for patient management decisions and enables more precise cancer treatment. Here, we present a quantitative proteotyping approach based on sequential windowed acquisition of all theoretical f
Externí odkaz:
https://doaj.org/article/d8d0b79b7047470b9f630f406e4fb787
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 11, p e1004590 (2015)
Cancer genomes contain vast amounts of somatic mutations, many of which are passenger mutations not involved in oncogenesis. Whereas driver mutations in protein-coding genes can be distinguished from passenger mutations based on their recurrence, non
Externí odkaz:
https://doaj.org/article/11086cce95c6426f858f1a455260a575
Autor:
Rekin's Janky, Annelien Verfaillie, Hana Imrichová, Bram Van de Sande, Laura Standaert, Valerie Christiaens, Gert Hulselmans, Koen Herten, Marina Naval Sanchez, Delphine Potier, Dmitry Svetlichnyy, Zeynep Kalender Atak, Mark Fiers, Jean-Christophe Marine, Stein Aerts
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 7, p e1003731 (2014)
Identifying master regulators of biological processes and mapping their downstream gene networks are key challenges in systems biology. We developed a computational method, called iRegulon, to reverse-engineer the transcriptional regulatory network u
Externí odkaz:
https://doaj.org/article/709d0c14a614436cbd7be589f1fbc7a4
Autor:
Patrick Laurette, Thomas Strub, Dana Koludrovic, Céline Keime, Stéphanie Le Gras, Hannah Seberg, Eric Van Otterloo, Hana Imrichova, Robert Siddaway, Stein Aerts, Robert A Cornell, Gabrielle Mengus, Irwin Davidson
Publikováno v:
eLife, Vol 4 (2015)
Microphthalmia-associated transcription factor (MITF) is the master regulator of the melanocyte lineage. To understand how MITF regulates transcription, we used tandem affinity purification and mass spectrometry to define a comprehensive MITF interac
Externí odkaz:
https://doaj.org/article/b685e02106604747b3e01f01e7b91f35