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Autor:
Ann Rowley, Brian S. Brown, Mary Stofega, Hana Hoh, Rebecca Mathew, Violeta Marin, Rong-Xian Ding, Ryan A. McClure, Fabiola M. Bittencourt, Jun Chen, Tarikere Gururaja, Taisei Kinoshita, Xueqing Wang, Alexey Rivkin, Kevin R. Woller
Publikováno v:
ACS Chemical Biology. 17:1315-1320
Interleukin-1 receptor-associated kinase 3 (IRAK3) is a pseudokinase mediator in the human inflammatory pathway, and ablation of its function is associated with enhanced antitumor immunity. Traditionally, pseudokinases have eluded "druggability" and