Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Hana Friedman"'
Publikováno v:
PLoS Genetics, Vol 16, Iss 8, p e1008752 (2020)
Myelin is composed of plasma membrane spirally wrapped around axons and compacted into dense sheaths by myelin-associated proteins. Myelin is elaborated by neuroepithelial derived oligodendrocytes in the central nervous system (CNS) and by neural cre
Externí odkaz:
https://doaj.org/article/79ed90049c82461da72b7d8bf576e2ba
Myelin is composed of plasma membrane spirally wrapped around axons and compacted into dense sheaths by myelin associated proteins. In the central nervous system (CNS), myelin is elaborated by neuroepithelial derived oligodendrocytes and in the perip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac78abf1a0bdd567d4906266b1c8830
https://doi.org/10.1101/2020.04.03.023473
https://doi.org/10.1101/2020.04.03.023473
Publikováno v:
PLoS Genetics, Vol 16, Iss 8, p e1008752 (2020)
PLoS Genetics
PLoS Genetics
Myelin is composed of plasma membrane spirally wrapped around axons and compacted into dense sheaths by myelin-associated proteins. Myelin is elaborated by neuroepithelial derived oligodendrocytes in the central nervous system (CNS) and by neural cre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2bb4c485713311f27dd961c899a0ab
https://doi.org/10.1371/journal.pgen.1008752
https://doi.org/10.1371/journal.pgen.1008752
Autor:
Eric Denarier, Thomas J. Hudson, Bente Finsen, Nancy Dionne, Tanja Kuhlmann, Maia V. Kokoeva, Kathy Siminovitch, Hana Friedman, Régen Drouin, Alan C. Peterson, Samar Dib
Publikováno v:
Glia. 64:175-194
In mammals, large caliber axons are ensheathed by myelin, a glial specialization supporting axon integrity and conferring accelerated and energy-efficient action potential conduction. Myelin basic protein (MBP) is required for normal myelin elaborati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e610fd22b76b0868615a612e3db372fe
https://doi.org/10.1002/glia.22923
https://doi.org/10.1002/glia.22923
Autor:
Amke Hesse, Wolfgang Brück, Hana Friedman, Alan C. Peterson, Tanja Kuhlmann, Alexander Lürbke, Karin Hagemeier, Jasmin Held
Publikováno v:
Glia. 60:271-280
Oligodendroglial damage and loss are typical characteristics of demyelinating diseases such as multiple sclerosis (MS) and the leukodystrophies. Axonal loss is the underlying cause of permanent neurological deficits in MS and it is thought to arise f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e712a8f280d052691fc1ce86a5c345
https://doi.org/10.1002/glia.21261
https://doi.org/10.1002/glia.21261
Publikováno v:
genesis. 46:229-234
Employing the Hprt locus as the site for targeted transgenesis we have developed mice expressing the tamoxifen-inducible Cre-ER(T2) fusion protein under the control of the ARR2-rat probasin promoter. This system enables external control over the timi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbd0696473872af0f84e38d06beb0b5
https://doi.org/10.1002/dvg.20386
https://doi.org/10.1002/dvg.20386
Autor:
Abhijnan Chattopadhyay, Reed B. Jacob, Hung Q. Doan, Owen M. McDougal, Sunil Kumar Verma, Hana Friedman, Muge N. Kuyumcu-Martinez, Ken Fujise, Alan C. Peterson, Decha Pinkaew
Publikováno v:
Scientific Reports
Fortilin, a pro-survival molecule, inhibits p53-induced apoptosis by binding to the sequence-specific DNA-binding domain of the tumor suppressor protein and preventing it from transcriptionally activating Bax. Intriguingly, fortilin protects cells ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b0368f099692f24dfcad7cf4714298
https://pubmed.ncbi.nlm.nih.gov/26726832
https://pubmed.ncbi.nlm.nih.gov/26726832
Autor:
Hana Friedman, Alan C. Peterson, Rima Rozen, Daniel Leclerc, Qing Wu, Laura Pickell, Xiao-Ling Wang
Publikováno v:
Mammalian genome : official journal of the International Mammalian Genome Society. 22(11-12)
Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, synthesizes 5-methyltetrahydrofolate, the main circulatory form of folate which is required for maintaining nontoxic levels of homocysteine and providing one-carbon units
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e8bd7d8a1d7735ea394ed63204cba9
https://pubmed.ncbi.nlm.nih.gov/21769670
https://pubmed.ncbi.nlm.nih.gov/21769670
Autor:
Hana Friedman, Jean-Pierre Julien
Publikováno v:
Neuroprotocols. 3:69-80
The transgenic mouse technology offers the opportunity to introduce or to replace genetic information in the mouse germ line. We discuss the advantages and limitations of the various methods of creating transgenic animals as well as their potential a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6befb6e32f0b5c1d4c91a97ac55efcef
https://doi.org/10.1006/ncmn.1993.1039
https://doi.org/10.1006/ncmn.1993.1039
Autor:
Natalia I. Krupenko, Rima Rozen, Hana Friedman, Andrea K. Lawrance, Alan C. Peterson, Basak Celtikci, Liyuan Deng, Stepan Melnyk, Sergey A. Krupenko, Daniel Leclerc, S. Jill James
Publikováno v:
Pharmacogenetics and genomics. 18(7)
Folates provide one-carbon units for nucleotide synthesis and methylation reactions. A common polymorphism (677C--T) in methylenetetrahydrofolate reductase (MTHFR) encodes an enzyme with reduced activity. Response to the antifolate methotrexate (MTX)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4613d4f37433e1042d6f7f2fc531737
https://pubmed.ncbi.nlm.nih.gov/18551038
https://pubmed.ncbi.nlm.nih.gov/18551038