Total Synthesis of the Four Stereoisomers of Cyclo(l-Trp-l-Arg) Raises Uncertainty of the Structures of the Natural Products and Invalidates Their Promising Antimicrobial Activities

Autor: Dan Chen, Daniel J. Park, Melissa M. Cadelis, Hana Douafer, Marie Lise Bourguet-Kondracki, Jean Michel Brunel, Brent R. Copp

Publikováno v: Molecules, Vol 27, Iss 18, p 5913 (2022)

New therapeutic options to combat the growing incidence of antimicrobial resistance are urgently needed. A 2015 publication reported the isolation and biological evaluation of two diketopiperazine natural products, cyclo(l-Trp-l-Arg) (CDP 2) and cycl

Externí odkaz: https://doaj.org/article/f614c007e2af444fae03e9a2b25717fd

Antibiotic adjuvants to rescue Pseudomonas aeruginosa from tetracycline antibiotics resistance

Autor: Jean M. Brunel, Hana Douafer, Naouel Klibi, Azza Troudi, Jean-Michel Bolla

Publikováno v: Anti-Infective Agents
Anti-Infective Agents, Bentham Science Publishers, In press, ⟨10.2174/2211352518999200629164624⟩
Anti-Infective Agents, In press, ⟨10.2174/2211352518999200629164624⟩

Introduction: An attractive antibiotic-adjuvant strategy consisting of the design and synthesis of polyaminoisoprenyl molecules able to restore the antibiotic activity of tetracycline antibiotics against resistant Pseudomonas aeruginosa bacterial str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95c6f8ef980434d5c0cebb72393d5b1
https://doi.org/10.2174/2211352518999200629164624

Spermine Derivatives of Indole‐3‐carboxylic Acid, Indole‐3‐acetic Acid and Indole‐3‐acrylic Acid as Gram‐Negative Antibiotic Adjuvants

Autor: Brent R. Copp, Marie-Lise Bourguet-Kondracki, Jean Michel Brunel, Marine Blanchet, Steven A. Li, Melissa M. Cadelis, Hana Douafer

Publikováno v: ChemMedChem
ChemMedChem, 2020, ⟨10.1002/cmdc.202000359⟩
ChemMedChem, Wiley-VCH Verlag, 2021, 16 (3), pp.513-523. ⟨10.1002/cmdc.202000359⟩
ChemMedChem, Wiley-VCH Verlag, 2020, ⟨10.1002/cmdc.202000359⟩

International audience; The discovery of new antibiotic adjuvants is an attractive option for overcoming antimicrobial resistance. We have previously reported the discovery of a bis-6-bromoindolglyoxylamide derivative of spermine as being able to enh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbeb1f33333b9ecfa1428ccf7498c7f
https://hal.science/hal-03084985

Characterization of a new aerosol antibiotic/adjuvant combination for the treatment of P. aeruginosa lung infections

Autor: Hana Douafer, Emmanuel Wafo, Véronique Andrieu, Jean Michel Brunel

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, 2020, 586, pp.119548. ⟨10.1016/j.ijpharm.2020.119548⟩
International Journal of Pharmaceutics, Elsevier, 2020, 586, pp.119548. ⟨10.1016/j.ijpharm.2020.119548⟩

International audience; The lack of novel classes of antibiotics as well as the constant increase of multidrug resistant bacteria are leaving the clinicians disarmed to treat bacterial infections, especially those caused by Gram-negative pathogens. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff26cc951feb32ed2f54529d7c40d74c
https://hal.science/hal-03085007

Antibiotic Adjuvants: Make Antibiotics Great Again!

Autor: Jean Michel Brunel, Hana Douafer, Véronique Andrieu, Otto Phanstiel

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2019, 62 (19), pp.8665-8681. ⟨10.1021/acs.jmedchem.8b01781⟩
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (19), pp.8665-8681. ⟨10.1021/acs.jmedchem.8b01781⟩

Multiple approaches have been developed to combat bacterial resistance. However, the combination of antibiotic resistance mechanisms by bacteria and the limited number of effective antibiotics available decreases the effective interventions for the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa77880e6c1d9cddbd926ff0630c4374
https://pubmed.ncbi.nlm.nih.gov/31961155