Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Hana Chodounska"'
Autor:
Eva Kudova, Pavel Mares, Martin Hill, Katerina Vondrakova, Grygoriy Tsenov, Hana Chodounska, Hana Kubova, Karel Vales
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 49 (2021)
Pregnanolone glutamate (PA-G) is a neuroactive steroid that has been previously demonstrated to be a potent neuroprotective compound in several biological models in vivo. Our in vitro experiments identified PA-G as an inhibitor of N-methyl-D-aspartat
Externí odkaz:
https://doaj.org/article/421a4e406dcf4dc3bc8960197d4845d4
Autor:
Kristina Holubova, Marketa Chvojkova, Barbora Hrcka Krausova, Vojtech Vyklicky, Eva Kudova, Hana Chodounska, Ladislav Vyklicky, Karel Vales
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 1026 (2021)
Evidence from clinical and preclinical studies implicates dysfunction of N-methyl-D-aspartate receptors (NMDARs) in schizophrenia progression and symptoms. We investigated the antipsychotic effect of two neuroactive steroids in an animal model of sch
Externí odkaz:
https://doaj.org/article/d697bc39daff4bd4944bbb038ff09afb
Autor:
Santosh Kumar Adla, Barbora Slavikova, Hana Chodounska, Vojtech Vyklicky, Marek Ladislav, Pavla Hubalkova, Barbora Krausova, Tereza Smejkalova, Michaela Nekardova, Marketa Smidkova, Lenka Monincova, Radko Soucek, Ladislav Vyklicky, Eva Kudova
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Herein, we report the synthesis, structure-activity relationship study, and biological evaluation of neurosteroid inhibitors of N-methyl-D-aspartate receptors (NMDARs) receptors that employ an amide structural motif, relative to pregnanolone glutamat
Externí odkaz:
https://doaj.org/article/a55dc849289842f38467a237736ab7f8
Autor:
Vojtech Vyklicky, Barbora Krausova, Jiri Cerny, Marek Ladislav, Tereza Smejkalova, Bohdan Kysilov, Miloslav Korinek, Sarka Danacikova, Martin Horak, Hana Chodounska, Eva Kudova, Ladislav Vyklicky
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
N-methyl-D-aspartate receptors (NMDARs), glutamate-gated ion channels, mediate signaling at the majority of excitatory synapses in the nervous system. Recent sequencing data for neurological and psychiatric patients have indicated numerous mutations
Externí odkaz:
https://doaj.org/article/8336effcabeb4179b9a7a9b0c53561ce
Autor:
Vera Abramova, Vanessa Leal Alvarado, Martin Hill, Tereza Smejkalova, Michal Maly, Karel Vales, Ivan Dittert, Paulina Bozikova, Bohdan Kysilov, Barbora Hrcka Krausova, Vojtech Vyklicky, Ales Balik, Klevinda Fili, Miloslav Korinek, Hana Chodounska, Eva Kudova, David Ciz, Jan Martinovic, Jiri Cerny, Petr Bartunek, Ladislav Vyklicky
Publikováno v:
ACS Chemical Neuroscience. 14:1870-1883
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc2b7cd320048bf937e1c5137a6017c9
https://doi.org/10.1021/acschemneuro.3c00131
https://doi.org/10.1021/acschemneuro.3c00131
Autor:
Bohdan Kysilov, Barbora Hrcka Krausova, Vojtech Vyklicky, Tereza Smejkalova, Miloslav Korinek, Martin Horak, Hana Chodounska, Eva Kudova, Jiri Cerny, Ladislav Vyklicky
Publikováno v:
British Journal of Pharmacology. 179:3970-3990
N-methyl-D-aspartate receptors (NMDARs) play a critical role in synaptic plasticity, and mutations in human genes encoding NMDAR subunits have been described in individuals with various neuropsychiatric disorders. Compounds with a positive allosteric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b366851c9ae176d19945812da2ec7eb0
https://doi.org/10.1111/bph.15841
https://doi.org/10.1111/bph.15841
Autor:
Eva Kudova, Barbora Krausova, Ladislav Vyklicky, Jan Krusek, Tereza Smejkalova, Hana Chodounska, Dragana Hajdukovic, Miriam Candelas Serra, Miloslav Korinek
Publikováno v:
British Journal of Pharmacology
Background and purpose Neurosteroids influence neuronal function and have multiple promising clinical applications. Direct modulation of postsynaptic neurotransmitter receptors by neurosteroids is well characterized, but presynaptic effects remain po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759a84b81c9af5633d8a9c074bbc9eca
https://doi.org/10.1111/bph.15529
https://doi.org/10.1111/bph.15529
Autor:
Jiri Cerny, Ladislav Vyklicky, Barbora Krausova, Zaneta Naimová, Marek Ladislav, Miloslav Korinek, Jan Krusek, Bohdan Kysilov, Eva Kudova, Pavla Hubalkova, Vojtech Vyklicky, Tereza Smejkalova, Hana Chodounska
Publikováno v:
J Neurosci
NMDARs are ligand-gated ion channels that cause an influx of Na+and Ca2+into postsynaptic neurons. The resulting intracellular Ca2+transient triggers synaptic plasticity. When prolonged, it may induce excitotoxicity, but it may also activate negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844eb8adb59ea5add8fb3221621f28ff
https://doi.org/10.1523/jneurosci.2654-20.2021
https://doi.org/10.1523/jneurosci.2654-20.2021
Autor:
Miloslav Korinek, Barbora Krausova, Ladislav Vyklicky, Hana Chodounska, Vojtech Vyklicky, Tereza Smejkalova, Bohdan Kysilov, Eva Kudova, Ales Balik, Jiri Cerny, Marek Ladislav
Publikováno v:
The Journal of Neuroscience. 40:5922-5936
N-methyl-D-aspartate receptor (NMDAR) hypofunction has been implicated in several neurodevelopmental disorders. NMDAR function can be augmented by positive allosteric modulators, including endogenous compounds, such as cholesterol and neurosteroid pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65c810e9443bd12551585f51aba1af71
https://doi.org/10.1523/jneurosci.3010-19.2020
https://doi.org/10.1523/jneurosci.3010-19.2020
Autor:
Eva Kudova, Vojtech Vyklicky, Hana Chodounska, Marketa Chvojkova, Barbora Krausova, Karel Vales, Kristina Holubova, Ladislav Vyklicky
Publikováno v:
Biomolecules
Volume 11
Issue 7
Biomolecules, Vol 11, Iss 1026, p 1026 (2021)
Volume 11
Issue 7
Biomolecules, Vol 11, Iss 1026, p 1026 (2021)
Evidence from clinical and preclinical studies implicates dysfunction of N-methyl-D-aspartate receptors (NMDARs) in schizophrenia progression and symptoms. We investigated the antipsychotic effect of two neuroactive steroids in an animal model of sch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8150bc71a1100d59f2e24311e72baf04