Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Han-kun Zhang"'
Autor:
Zhenxi Li, Xinghai Yang, Ruifeng Fu, Zhipeng Wu, Shengzhao Xu, Jian Jiao, Ming Qian, Long Zhang, Chunbiao Wu, Tianying Xie, Jiqiang Yao, Zhixiang Wu, Wenjun Li, Guoli Ma, Yu You, Yihua Chen, Han-kun Zhang, Yiyun Cheng, Xiaolong Tang, Pengfei Wu, Gewei Lian, Haifeng Wei, Jian Zhao, Jianrong Xu, Lianzhong Ai, Stefan Siwko, Yue Wang, Jin Ding, Gaojie Song, Jian Luo, Mingyao Liu, Jianru Xiao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Osteoclasts are over-activated as we age, which results in bone loss. Src deficiency in mice leads to severe osteopetrosis due to a functional defect in osteoclasts, indicating that Src function is essential in osteoclasts. G-protein-coupled
Externí odkaz:
https://doaj.org/article/0890b5c3600c4d14b91eb72f87712feb
Autor:
Wei Wang, Jiacheng He, Junjie Yang, Chan Zhang, Zhiyuan Cheng, Yao Zhang, Qiansen Zhang, Peili Wang, Shuowen Tang, Xin Wang, Mingyao Liu, Weiqiang Lu, Han-Kun Zhang
Publikováno v:
Journal of medicinal chemistry. 65(11)
Cancer cells can effectively suppress the natural immune response in humans, and prostaglandin E
Autor:
Jun-Jie, Yang, Wei-Wei, Yu, Long-Long, Hu, Wen-Juan, Liu, Xian-Hua, Lin, Wei, Wang, Qiansen, Zhang, Pei-Li, Wang, Shuo-Wen, Tang, Xin, Wang, Mingyao, Liu, Weiqiang, Lu, Han-Kun, Zhang
Publikováno v:
Journal of medicinal chemistry. 63(2)
The prostanoid EP4 receptor is one of the key receptors associated with inflammatory mediator PGE
Autor:
Li-Fang Yu, J. Brek Eaton, Alan P. Kozikowski, Han Kun Zhang, Ronald J. Lukas, Barbara J. Caldarone
Publikováno v:
Journal of Medicinal Chemistry. 57:8204-8223
Nicotinic acetylcholine receptors (nAChRs) have been investigated for developing drugs that can potentially treat various central nervous system disorders. Considerable evidence supports the hypothesis that modulation of the cholinergic system throug
Autor:
Oluseye K. Onajole, Dani Brunner, J. Brek Eaton, Li-Fang Yu, Allison Fedolak, Hendra Gunosewoyo, Han Kun Zhang, Ronald J. Lukas, Alan P. Kozikowski
We previously reported the cyclopropylpyridine and isoxazolylpyridine ether scaffolds to be versatile building blocks for creating potent α4β2 nicotinic acetylcholine receptor (nAChR) partial agonists with excellent selectivity over the α3β4 subt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3a9f05eefcc149a307e2923ae03bd8
https://europepmc.org/articles/PMC5097879/
https://europepmc.org/articles/PMC5097879/
Autor:
Taleen Hanania, Han Kun Zhang, Ronald J. Lukas, Alan P. Kozikowski, J. Brek Eaton, Oluseye K. Onajole, Daniela Brunner, Li-Fang Yu, Paul Whiteaker
Publikováno v:
Journal of Medicinal Chemistry. 56:5495-5504
A 3-pyridyl ether scaffold bearing a cyclopropane-containing side chain was recently identified in our efforts to create novel antidepressants that act as partial agonists at α4β2-nicotinic acetylcholine receptors. In this study, a systematic struc
Publikováno v:
ACS Medicinal Chemistry Letters. 3:1054-1058
Comparative analyses of the pharmacophoric elements required for σ1 and nicotinic ligands led to the identification of a potent and selective σ1 ligand (15). Compound 15 displayed high selectivity for the σ1 receptor (Ki, σ1 = 4.1 nM; Ki, σ2 = 1
Autor:
Yong Chang Chang, Taleen Hanania, Paul Whiteaker, Guannan Li, Jie Wu, J. Brek Eaton, Ronald J. Lukas, Richard B. van Breemen, Alan P. Kozikowski, Emily Sabath, Han Kun Zhang, Qiang Liu, Li-Fang Yu, Dani Brunner
Publikováno v:
Pharmacology Research & Perspectives. 2
Preclinical and clinical studies demonstrated that the inhibition of cholinergic supersensitivity through nicotinic antagonists and partial agonists can be used successfully to treat depressed patients, especially those who are poor responders to sel
Autor:
Li-Fang, Yu, J, Brek Eaton, Han-Kun, Zhang, Emily, Sabath, Taleen, Hanania, Guan-Nan, Li, Richard B, van Breemen, Paul, Whiteaker, Qiang, Liu, Jie, Wu, Yong-Chang, Chang, Ronald J, Lukas, Dani, Brunner, Alan P, Kozikowski
Publikováno v:
Pharmacology Research & Perspectives
Preclinical and clinical studies demonstrated that the inhibition of cholinergic supersensitivity through nicotinic antagonists and partial agonists can be used successfully to treat depressed patients, especially those who are poor responders to sel
Autor:
Han Kun Zhang, Taleen Hanania, Ronald J. Lukas, J. Brek Eaton, Alan P. Kozikowski, Li-Fang Yu, Allison Fedolak, Dani Brunner
Publikováno v:
Journal of medicinal chemistry. 55(22)
In our continued efforts to develop α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists as novel antidepressants having a unique mechanism of action, structure-activity relationship (SAR) exploration of certain isoxazolylpyridine ethers