Hematopoietic cell-mediated dissemination of murine cytomegalovirus is regulated by NK cells and immune evasion

Autor: Renee G. Espinosa Trethewy, Shunchuan Zhang, Lindsey M. Bishop, Meaghan H. Hancock, Finn Grey, Lauren E. Springer, Han Zhi Rao, Christopher M. Snyder

Publikováno v: PLoS Pathogens, Vol 17, Iss 1, p e1009255 (2021)
PLoS Pathogens
Zhang, S, Springer, L E, Rao, H-Z, Espinosa Trethewy, R G, Bishop, L M, Hancock, M H, Grey, F & Snyder, C M 2021, ' Hematopoietic cell-mediated dissemination of murine cytomegalovirus is regulated by NK cells and immune evasion ', PLoS Pathogens, vol. 17, no. 1, e1009255 . https://doi.org/10.1371/journal.ppat.1009255

Cytomegalovirus (CMV) causes clinically important diseases in immune compromised and immune immature individuals. Based largely on work in the mouse model of murine (M)CMV, there is a consensus that myeloid cells are important for disseminating CMV f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8781e582d9ccc839231128b39091103a
https://doaj.org/article/2f6f486f74ff4dc9bae97d0eadfcc6a2

Intravenous injection of AAVrh10-GALC after the neonatal period in twitcher mice results in significant expression in the central and peripheral nervous systems and improvement of clinical features

Autor: Mark T. Curtis, Han Zhi Rao, David A. Wenger, Mohammad A. Rafi, Paola Luzi, Alice Luddi

Publikováno v: Molecular Genetics and Metabolism. 114:459-466

Globoid cell leukodystrophy (GLD) or Krabbe disease is an autosomal recessive disorder resulting from the defective lysosomal enzyme galactocerebrosidase (GALC). The lack of GALC enzyme leads to severe neurological symptoms. While most human patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81134a7defd4b859243039c368a6331e
https://doi.org/10.1016/j.ymgme.2014.12.300

Biochemical and pathological evaluation of long-lived mice with globoid cell leukodystrophy after bone marrow transplantation

Autor: Paola Luzi, Marie T. Vanier, Han Zhi Rao, Mohammad A. Rafi, Mark T. Curtis, David A. Wenger, Mariam Zaka

Publikováno v: Molecular Genetics and Metabolism. 86:150-159

Globoid cell leukodystrophy (GLD) is a disorder of the central and peripheral nervous systems caused by the deficiency of the lysosomal enzyme galactocerebrosidase (GALC). The pathological changes associated with the disease include accumulation of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da45ab9ea92db4e77cb5ea42173a9a7
https://doi.org/10.1016/j.ymgme.2005.06.023

Sixteen novel mutations in the arylsulfatase A gene causing metachromatic leukodystrophy

Autor: Mohammad A. Rafi, Paola Luzi, Han Zhi Rao, David A. Wenger

Publikováno v: Gene. 530(2)

Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused mainly by mutations in the arylsulfatase A (ARSA) gene. In this manuscript we report sixteen novel mutations identified in the ARSA gene of fifteen unrelated patients affected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ca835e6bad465101aac7c5599b431b
https://pubmed.ncbi.nlm.nih.gov/24001781

212. Delivery of Galactocerebrosidase Activity to the Peripheral Nervous System of Mice with Globoid Cell Leukodystrophy (Krabbe Disease) by Intramuscular Injection

Autor: Paola Luzi, Mark T. Curtis, David A. Wenger, Mohammad A. Rafi, Han Zhi Rao

Publikováno v: Molecular Therapy. 13

Globoid cell leukodystrophy (GLD) or Krabbe disease is a neurodegenerative disorder that affects both the central and peripheral nervous system (CNS and PNS). The deficiency of the lysosomal enzyme galactocerebrosidase (GALC) leads to the accumulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c27a54c5ef671c1206010586e9d3a6