Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Han-Yue Qiu"'
Autor:
Han-Yue Qiu, Xiang Zhu, Yue-Lin Luo, Hong-Yan Lin, Cheng-Yi Tang, Jin-Liang Qi, Yan-Jun Pang, Rong-Wu Yang, Gui-Hua Lu, Xiao-Ming Wang, Yong-Hua Yang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Signal transducer and activator of transcription 3 (STAT3) is hyper-activated in diversiform human tumors and has been validated as an attractive therapeutic target. Current research showed that a natural product, shikonin, along with its sy
Externí odkaz:
https://doaj.org/article/aff6189e0a284adcb62ed7e81cccab4e
Autor:
Ji-Wen Yuan, Han-Yue Qiu, Peng-Fei Wang, Jigar A. Makawana, Yong-An Yang, Fei Zhang, Yong Yin, Jie Lin, Zhong-Chang Wang, Hai-Liang Zhu
Publikováno v:
Molecules, Vol 19, Iss 6, Pp 7269-7286 (2014)
A series of caffeic acid amides D1-D17 bearing 2,3,4,5-tetrahydrobenzo-[b][1,4]dioxocine units has been synthesized and their biological activities evaluated for potential antiproliferative and EGFR inhibitory activity. Of all the compounds studied,
Externí odkaz:
https://doaj.org/article/393313e2ae3842aca1689a6f4354fc56
Publikováno v:
Expert opinion on therapeutic patents. 32(11)
Indoleamine 2,3-dioxygenase 1 (IDO1) is highly related to the immune evasion of a wide range of malignancies due to its role in the immune suppression caused by the depletion of tryptophan (Trp) and the accumulation of kynurenine (Kyn). The combinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b199b8842aa347b4c967fb711eb0cd13
https://pubmed.ncbi.nlm.nih.gov/36420761
https://pubmed.ncbi.nlm.nih.gov/36420761
Publikováno v:
Expert Opinion on Therapeutic Patents. 31:965-975
The mammalian target of rapamycin (mTOR) kinase is a central component in the PI3K/Akt/mTOR pathway and plays a crucial role in tumor biology, making it one appealing therapeutic target. In the past decade, the mTORi (mTOR inhibitor) development fiel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f47ac51206b54f8c942d2fffa71b8b6
https://doi.org/10.1080/13543776.2021.1940137
https://doi.org/10.1080/13543776.2021.1940137
Publikováno v:
Expert Opinion on Therapeutic Patents. 30:795-805
Cyclin-dependent kinases 4 and 6 (CDK4/6) along with their upstream/downstream components are pivotal regulators for the cell cycle progression. The dysfunction of CDK4/6 is the common feature and promoting factor in various cancer types. In-depth re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb9321736ceb16bf4fb83e9c057638a
https://doi.org/10.1080/13543776.2020.1825686
https://doi.org/10.1080/13543776.2020.1825686
Publikováno v:
Current topics in medicinal chemistry. 21(28)
With the rapid development of computer science in scopes of theory, software, and hardware, artificial intelligence (mainly in form of machine learning and more complex deep learning) combined with advanced cheminformatics is playing an increasingly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63bfdcbe577002bbf65f68b28add3eb
https://pubmed.ncbi.nlm.nih.gov/33982652
https://pubmed.ncbi.nlm.nih.gov/33982652
Autor:
Hui-Min Hu, Yue Huang, Ze-Feng Wang, Han-Yue Qiu, Zhong-Chang Wang, Hai-Liang Zhu, Peng-Fei Wang
Publikováno v:
ChemMedChem. 13:2558-2566
The mitogen-activated protein kinase (MAPK) pathway plays a vital role in signal transduction networks. Severe diseases may be triggered if it is disturbed by mutated components, especially the kinase B-RafV600E . New inhibitors of the kinase are nee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b1cae5d76e487c47a287e75c6b47969
https://doi.org/10.1002/cmdc.201800574
https://doi.org/10.1002/cmdc.201800574
Autor:
Yong-Jiao Zhang, Dong Wang, Han-Yue Qiu, Peng-Fei Wang, Hai-Liang Zhu, Hui-Min Hu, Chen Xu, Zhong-Chang Wang
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:2372-2380
The association of deregulated signal pathways with various diseases has long been a research hotspot. One of the most important signal pathways, the MAPK (mitogen-activated protein kinase) signal pathway, plays a vital role in transducing extracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a594802fc6b8c21296722ecd62f7de4c
https://doi.org/10.1016/j.bmc.2018.03.038
https://doi.org/10.1016/j.bmc.2018.03.038
Autor:
Cheng-Yi Tang, Jin-Liang Qi, Peng-Fei Wang, Jiang-Yan Fu, Ya-Han Zhang, Han-Yue Qiu, Hong-Wei Han, Hai-Liang Zhu, Rong-Wu Yang, Yong-Hua Yang, Xiao-Ming Wang, Min-Kai Yang, Lin Hongyan
Publikováno v:
Biochemical Pharmacology. 146:74-86
The signal transducer and activator of transcription 3 is a constitutively activated oncogenic protein in various human tumors and represents a valid target for anticancer drug design. In this study, we have achieved a new type of STAT3 inhibitors ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99256086b830c18fa9d17885d2ac20d
https://doi.org/10.1016/j.bcp.2017.10.009
https://doi.org/10.1016/j.bcp.2017.10.009
Publikováno v:
Chemical Biology & Drug Design. 91:681-690
Naturally occurring naphthoquinones, usually in forms of botanical extracts, have been implicated with human life since ancient time, far earlier than their isolation and identification in modern era. The long use history of naphthoquinones has witne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9d14f8e289a23aeb619486c6443f86
https://doi.org/10.1111/cbdd.13141
https://doi.org/10.1111/cbdd.13141