Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Han-Xun Wei"'
Publikováno v:
Molecules, Vol 7, Iss 1, Pp 89-95 (2002)
a,b-Ethyl thioacrylate was difuctionalized by a tandem X-C/C=C bond formation reaction. The new system uses Ti (IV) halide as both the Lewis acidic promoter and the halogen source for the Michael-type addition onto the thioacrylate. The titanium enol
Externí odkaz:
https://doaj.org/article/63f35ce62db0473c87453122635b4812
Publikováno v:
Molecules, Vol 5, Iss 12, Pp 1408-1416 (2000)
A three-component halogeno aldol reaction has been developed by using titanium tetrachloride as the halogen source as well as the Lewis acid mediator. The dehydration and elimination of hydrogen chloride were inhibited by conducting the reaction at 0
Externí odkaz:
https://doaj.org/article/b8ddd6cec872469eae3804c3f6f78c91
Autor:
Jing Zhang, Dennis J. Selkoe, Michael S. Wolfe, Wenjuan Ye, Han-Xun Wei, Dai Lu, Yongli Gu, Pamela Osenkowski, Corinne E. Augelli-Szafran, Vivien Sun
Publikováno v:
Bioorg Med Chem Lett
One therapeutic approach for Alzheimer's disease is to inhibit the cleavage of the amyloid precursor protein (APP) by γ-secretase. At the beginning of a series of studies from our laboratories, a series of novel γ-amino alcohols (1) were found to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7871e2efb9ec024eb8ebe67104c6219
https://doi.org/10.1016/j.bmcl.2016.03.042
https://doi.org/10.1016/j.bmcl.2016.03.042
Autor:
Vibha Pathak, Mark J. Suto, Donald J. Buchsbaum, Patsy G. Oliver, Abhishek Gangrade, Han-Xun Wei, Corinne E. Augelli-Szafran
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 19; Issue 5; Pages: 1524
International Journal of Molecular Sciences; Volume 19; Issue 5; Pages: 1524
Wnt/β-catenin signaling is upregulated in triple-negative breast cancer (TNBC) compared to other breast cancer subtypes and normal tissues. Current Wnt/β-catenin inhibitors, such as niclosamide, target the pathway nonspecifically and exhibit poor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967c49754eb163ce421ef016708bd9ec
http://europepmc.org/articles/PMC5983770
http://europepmc.org/articles/PMC5983770
Autor:
Corinne E. Augelli-Szafran, Michael S. Wolfe, Yongli Gu, Dennis J. Selkoe, Jing Zhang, Han-Xun Wei, Dai Lu, Wenjuan Ye, Pamela Osenkowski
Publikováno v:
Bioorg Med Chem Lett
γ-Secretase is one of two proteases directly involved in the production of the amyloid β-peptide, (Aβ) which is pathogenic in Alzheimer’s disease. Inhibition of γ-secretase to suppress the production of Aβ should not block processing of one of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b031aeca784f22889539ebb4c372988
https://europepmc.org/articles/PMC8317589/
https://europepmc.org/articles/PMC8317589/
Autor:
Yongli Gu, Han-Xun Wei, Jing Zhang, Michael S. Wolfe, Corinne E. Augelli-Szafran, Dennis J. Selkoe, Dai Lu
Publikováno v:
Bioorg Med Chem Lett
In search for novel lead compounds as γ-secretase inhibitors, analogs of aminopyrido[2,3-d]pyrimidin-7-ones (I) were synthesized and evaluated for inhibitory effects on amyloid –β-peptide production and cleavage of the Notch1 receptor mediated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809b09da30c9157d5278f72c688eaf60
https://pubmed.ncbi.nlm.nih.gov/27038496
https://pubmed.ncbi.nlm.nih.gov/27038496
Publikováno v:
Tetrahedron. 60:11829-11835
The first example of a direct aldehyde–ketone coupling using the secondary amine piperidine as base in the presence of MgI2 to generate high selectivity of anti-aldol products from unmodified ethyl ketones in high yield is reported. The coupling re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74d29f3601b7eefc01ea687cc531d50
https://doi.org/10.1016/j.tet.2004.09.098
https://doi.org/10.1016/j.tet.2004.09.098
Publikováno v:
Tetrahedron. 60:10233-10237
The first time steroselective synthesis of ( Z )-β-bromo Baylis–Hillman ketones has been achieved using a one-pot three-component reaction. The new system uses MgBr 2 as both the Lewis acidic promoter and the bromine source for the Michael-type ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bba96d4c9a215c0fccaeda6db77a8577
https://doi.org/10.1016/j.tet.2004.08.097
https://doi.org/10.1016/j.tet.2004.08.097
Publikováno v:
Organic Letters. 6:4289-4292
Low-temperature crystal structures of three pyrrolediones (3-5) and a furandione (9) were obtained and compared to structurally related compounds that cannot undergo decarbonylation. Systematic trends in bond lengths and angles are consistent with di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcf8c6603f44b0b5e71d4573ff9025f
https://doi.org/10.1021/ol048197d
https://doi.org/10.1021/ol048197d
Publikováno v:
Helvetica Chimica Acta. 87:2359-2363
The efficient and highly stereoselective syntheses of a variety of (Z)-configured, substituted α-(hydroxymethyl)-β-iodo-acrylates from prop-2-ynoate and various aldehydes was achieved. The synthetic protocol involves a simple one-pot coupling react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96bb3832fcba005d09d644edbff5e610
https://doi.org/10.1002/hlca.200490212
https://doi.org/10.1002/hlca.200490212