Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Han-Sheng Chiu"'
Autor:
Drew R. Neavin, Angela M. Steinmann, Nona Farbehi, Han Sheng Chiu, Maciej S. Daniszewski, Himanshi Arora, Yasmin Bermudez, Cátia Moutinho, Chia-Ling Chan, Monique Bax, Mubarika Tyebally, Vikkitharan Gnanasambandapillai, Chuan E. Lam, Uyen Nguyen, Damián Hernández, Grace E. Lidgerwood, Robert M. Graham, Alex W. Hewitt, Alice Pébay, Nathan J. Palpant, Joseph E. Powell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The mechanisms by which DNA alleles contribute to disease risk, drug response, and other human phenotypes are highly context-specific, varying across cell types and different conditions. Human induced pluripotent stem cells are uniquely suit
Externí odkaz:
https://doaj.org/article/499bbef94bc84c94a2ef1a7bf2ddfd93
Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation
Autor:
Kris G. Alavattam, Katie A. Mitzelfelt, Giancarlo Bonora, Paul A. Fields, Xiulan Yang, Han Sheng Chiu, Lil Pabon, Alessandro Bertero, Nathan J. Palpant, William S. Noble, Charles E. Murry
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 159-174 (2023)
Summary: Vascular endothelial cells are a mesoderm-derived lineage with many essential functions, including angiogenesis and coagulation. The gene-regulatory mechanisms underpinning endothelial specialization are largely unknown, as are the roles of
Externí odkaz:
https://doaj.org/article/5f7f366be7be4a3e89f754bffcd612c1
Autor:
Drew Neavin, Quan Nguyen, Maciej S. Daniszewski, Helena H. Liang, Han Sheng Chiu, Yong Kiat Wee, Anne Senabouth, Samuel W. Lukowski, Duncan E. Crombie, Grace E. Lidgerwood, Damián Hernández, James C. Vickers, Anthony L. Cook, Nathan J. Palpant, Alice Pébay, Alex W. Hewitt, Joseph E. Powell
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Background The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) has provided a foundation for in vitro human disease modelling, drug development and population genetics studies. Gene expression plays
Externí odkaz:
https://doaj.org/article/d89867322e804dd0acd2dc0180fe5fe8
Autor:
Jun Xu, Caitlin Falconer, Quan Nguyen, Joanna Crawford, Brett D. McKinnon, Sally Mortlock, Anne Senabouth, Stacey Andersen, Han Sheng Chiu, Longda Jiang, Nathan J. Palpant, Jian Yang, Michael D. Mueller, Alex W. Hewitt, Alice Pébay, Grant W. Montgomery, Joseph E. Powell, Lachlan J.M Coin
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract A variety of methods have been developed to demultiplex pooled samples in a single cell RNA sequencing (scRNA-seq) experiment which either require hashtag barcodes or sample genotypes prior to pooling. We introduce scSplit which utilizes gen
Externí odkaz:
https://doaj.org/article/1b71a24d668b46c094a1546909858b98
Autor:
Sophie Shen, Tessa Werner, Yuliangzi Sun, Woo Jun Shim, Samuel Lukowski, Stacey Andersen, Han Sheng Chiu, Di Xia, Duy Pham, Zezhuo Su, Daniel Kim, Pengyi Yang, Xiaoli Chen, Men Chee Tan, Joseph E. Powell, Patrick P. L. Tam, Mikael Bodén, Joshua W. K. Ho, Quan Nguyen, Nathan J. Palpant
SUMMARYThis study develops a versatile cell multiplexing and data analysis platform to gain knowledge gain into mechanisms of cell differentiation. We engineer a cell barcoding system in human cells enabling multiplexed single-cell RNA sequencing for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e44f1be4a7707f91b5d4bdb5a8b4c72
https://doi.org/10.1101/2022.10.12.511862
https://doi.org/10.1101/2022.10.12.511862
Autor:
Clayton E. Friedman, Seth W. Cheetham, Richard J. Mills, Masahito Ogawa, Meredith A. Redd, Han Sheng Chiu, Sophie Shen, Yuliangzi Sun, Dalia Mizikovsky, Romaric Bouveret, Xiaoli Chen, Holly Voges, Scott Paterson, Jessica E. De Angelis, Stacey B. Andersen, Sohye Yoon, Geoffrey J. Faulkner, Kelly A. Smith, Richard P. Harvey, Benjamin M. Hogan, Quan Nguyen, Kazu Kikuchi, James E. Hudson, Nathan J. Palpant
SUMMARYThis study establishes the homeodomain only protein, HOPX, as a determinant controlling the molecular switch between cardiomyocyte progenitor and maturation gene programs. Time-course single-cell gene expression with genome-wide footprinting r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::353c9ee00ea26014ac95e0d230bf6bcb
https://doi.org/10.1101/2022.04.17.488603
https://doi.org/10.1101/2022.04.17.488603
Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation
Autor:
Kris G Alavattam, Katie A Mitzelfelt, Giancarlo Bonora, Paul A Fields, Xiulan Yang, Han Sheng Chiu, Lil Pabon, Alessandro Bertero, Nathan J Palpant, William S Noble, Charles E Murry
BackgroundVascular endothelial cells are a mesoderm-derived lineage with many essential functions, including angiogenesis and coagulation. However, the gene regulatory mechanisms that underpin endothelial specialization are largely unknown, as are th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2f8ec14caa29339d49b582e1ce2bf3
https://hdl.handle.net/2318/1882732
https://hdl.handle.net/2318/1882732
Autor:
Gregory A. Quaife-Ryan, Chun Yuen Chow, Nathan J. Palpant, Steven Petrou, Peter S. Macdonald, Glenn F. King, Enzo R. Porrello, Meredith A. Redd, Mark Hicks, Di Xia, Jacky Y. Suen, Sarah E. Scheuer, Yusuke Yoshikawa, Xiaoli Chen, Ling Gao, Melanie Y. White, Gabriel Cuellar-Partida, Stuart J. Cordwell, Walter G. Thomas, Ben Rollo, Jeanette E. Villanueva, James E. Hudson, Robert J. Hatch, Snezana Maljevic, Han Sheng Chiu, Yashutosh Joshi, Melissa E. Reichelt, Louise E. See Hoe, Mubarak A.H. Alzubaidi, John F. Fraser, Natalie J. Saez, Jason Nigel John Peart, Yuliangzi Sun
Background: Ischemia–reperfusion injury (IRI) is one of the major risk factors implicated in morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the buildup of acidic metabolites results in decreased intracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a87355930a63d2e18ca69d4c7ecfae
https://hdl.handle.net/10453/151624
https://hdl.handle.net/10453/151624
Autor:
Drew Neavin, Alice Pébay, Catia Moutinho, Grace E. Lidgerwood, Angela Steinmann, Han Sheng Chiu, Uyen Nguyen, Mubarika Tyebally, Chia-Ling Chan, Nathan J. Palpant, Vikkitharan Gnanasambandapillai, Joseph E. Powell, Maciej S. Daniszewski, Damián Hernández, Chuan E. Lam, Alex W. Hewitt
The mechanisms by which DNA alleles contribute to disease risk, drug response, and other human phenotypes are highly context-specific, varying across cell types and under different conditions. Human induced pluripotent stem cells (hiPSCs) are uniquel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e6e58c38f9c833db450f3c710189e85
https://doi.org/10.1101/2021.08.19.457030
https://doi.org/10.1101/2021.08.19.457030
Autor:
Redd, Meredith A., Scheuer, Sarah E., Saez, Natalie J., Yusuke Yoshikawa, Han Sheng Chiu, Ling Gao, Hicks, Mark, Villanueva, Jeanette E., Yashutosh Joshi, Chun Yuen Chow, Cuellar-Partida, Gabriel, Peart, Jason N., Hoe, Louise E. See, Xiaoli Chen, Yuliangzi Sun, Suen, Jacky Y., Hatch, Robert J., Rollo, Ben, Di Xia, Alzubaidi, Mubarak A. H.
Publikováno v:
Circulation; 9/21/2021, Vol. 144 Issue 12, p947-960, 14p