Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Han-Jou Chen"'
Autor:
Han-Jou Chen, Jacqueline C. Mitchell
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 6004 (2021)
TDP-43 is an RNA-binding protein that has been robustly linked to the pathogenesis of a number of neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal dementia. While mutations in the TARDBP gene that codes for the
Externí odkaz:
https://doaj.org/article/bf639c9825294687bb48ca52fa6d4bfe
Autor:
Youn-Bok Lee, Han-Jou Chen, João N. Peres, Jorge Gomez-Deza, Jan Attig, Maja Štalekar, Claire Troakes, Agnes L. Nishimura, Emma L. Scotter, Caroline Vance, Yoshitsugu Adachi, Valentina Sardone, Jack W. Miller, Bradley N. Smith, Jean-Marc Gallo, Jernej Ule, Frank Hirth, Boris Rogelj, Corinne Houart, Christopher E. Shaw
Publikováno v:
Cell Reports, Vol 5, Iss 5, Pp 1178-1186 (2013)
The GGGGCC (G4C2) intronic repeat expansion within C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Intranuclear neuronal RNA foci have been observed in ALS and FTD tissues, suggesting
Externí odkaz:
https://doaj.org/article/9cf3164a2c9e4faabd2f8beeacdd1d31
Autor:
Paul S. Sharp, Mohammed T. Akbar, Sonia Bouri, Atsushi Senda, Kieran Joshi, Han-Jou Chen, David S. Latchman, Dominic J. Wells, Jacqueline de Belleroche
Publikováno v:
Neurobiology of Disease, Vol 30, Iss 1, Pp 42-55 (2008)
Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder, characterised by progressive motor neuron degeneration and muscle paralysis. Heat shock proteins (HSPs) have significant cytoprotective properties in several models of neurodegene
Externí odkaz:
https://doaj.org/article/2529ed0680444d25b6bc2a0471a5c562
Autor:
Agnes L Nishimura, Carole Shum, Emma L Scotter, Amr Abdelgany, Valentina Sardone, Jamie Wright, Youn-Bok Lee, Han-Jou Chen, Bilada Bilican, Monica Carrasco, Tom Maniatis, Siddharthan Chandran, Boris Rogelj, Jean-Marc Gallo, Christopher E Shaw
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91269 (2014)
TDP-43 is found in cytoplasmic inclusions in 95% of amyotrophic lateral sclerosis (ALS) and 60% of frontotemporal lobar degeneration (FTLD). Approximately 4% of familial ALS is caused by mutations in TDP-43. The majority of these mutations are found
Externí odkaz:
https://doaj.org/article/fa42f11aa6034af69f65a96cb5723752
Autor:
Han-Jou Chen, 陳菡柔
93
In mammals, the development of hematopoietic system depends on cytokines. These cytokines not only mediate cell proliferation and differentiation, but also enhance the survival of these cells by the suppression of apoptotic pathways. Once the
In mammals, the development of hematopoietic system depends on cytokines. These cytokines not only mediate cell proliferation and differentiation, but also enhance the survival of these cells by the suppression of apoptotic pathways. Once the
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/87571043202536728741
Autor:
Jacqueline C. Mitchell, Han-Jou Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6004, p 6004 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
TDP-43 is an RNA-binding protein that has been robustly linked to the pathogenesis of a number of neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal dementia. While mutations in the TARDBP gene that codes for the
Autor:
Claire Troakes, Ho Sang Hui, Bradley N. Smith, Han-Jou Chen, Elsa Zacco, Annalisa Pastore, Andrew David King, Conor McLoughlin, Simon Topp, Malvika Katarya, Christopher Shaw
Publikováno v:
Brain
TDP-43 is a DNA/RNA binding protein, but whether its interactions with RNA are relevant to inclusion formation in ALS is unclear. Chen et al. report that mutated forms of TDP-43 that are unable to bind RNA have an increased tendency to aggregate, and
Autor:
Pranetha Baskaran, Leonard Petrucelli, Frank Hirth, Bradley N. Smith, Claire Troakes, Alan Stepto, Youn-Bok Lee, Agnes L. Nishimura, Christopher Shaw, Jorge Gomez-Deza, Boris Rogelj, Yoshitsugu Adachi, Sarah Guthrie, Han-Jou Chen, Jean-Marc Gallo
Publikováno v:
Human Molecular Genetics
Hum Mol Genet
Hum Mol Genet
An intronic GGGGCC (G4C2) hexanucleotide repeat expansion inC9orf72 is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD). Repeat-associated non-AUG (RAN) translation of G4C2 RNA can result in five
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7c0fa820b4838afa99fa708bb71ee8
Publikováno v:
Neurotherapeutics
Scotter, E L, Chen, H-J & Shaw, C E 2015, ' TDP-43 Proteinopathy and ALS : Insights into Disease Mechanisms and Therapeutic Targets ', Neurotherapeutics, vol. 12, no. 2, pp. 352-363 . https://doi.org/10.1007/s13311-015-0338-x
Scotter, E L, Chen, H-J & Shaw, C E 2015, ' TDP-43 Proteinopathy and ALS : Insights into Disease Mechanisms and Therapeutic Targets ', Neurotherapeutics, vol. 12, no. 2, pp. 352-363 . https://doi.org/10.1007/s13311-015-0338-x
Therapeutic options for patients with amyotrophic lateral sclerosis (ALS) are currently limited. However, recent studies show that almost all cases of ALS, as well as tau-negative frontotemporal dementia (FTD), share a common neuropathology character
Autor:
Claire Troakes, Federico Verde, Cinzia Tiloca, Simon Topp, Peter C. Sapp, Masatoshi Maki, Monkel Lek, Michael E. Weale, Kevin P. Kenna, Stephen E. Moss, Robert H. Brown, Karen E. Morrison, Jonathan D. Glass, Emma L. Scotter, Martina de Majo, Michael A. Simpson, Christopher Shaw, Jack W. Miller, Pamela J. Shaw, Alberto Garcia Redondo, Athina Soragia-Gkazi, Han-Jou Chen, Bradley N. Smith, Ammar Al-Chalabi, Hideki Shibata, Wejdan Kattuah, Vincenzo Silani, Jacqueline C. Mitchell, Anneloor L.M.A. ten Asbroek, Andrew P. King, Peter J. Nestor, Cinzia Gellera, Hardev Pall, Akane Sato, Jacqueline de Belleroche, Maryangel Jeon, Nigel Leigh, Martin R Turner, Janine Kirby, Frank Baas, Kevin Talbot, Jesús Esteban-Pérez, Safa Al-Sarraj, Orla Hardiman, Nicholas W Parkin, Claudia Fallini, Diana Marques Dias, Stefano Duga, Antonia Ratti, Christopher C.J. Miller, Caroline Vance, Chun Hao Wong, Nicola Ticozzi, John Landers, Matthew Nolan, J M Vianney de Jong
Publikováno v:
Science translational medicine 9(388), eaad9157 (2017). doi:10.1126/scitranslmed.aad9157
Smith, B N, Topp, S D, Fallini, C, Shibata, H, Chen, H-J, Troakes, C, King, A, Ticozzi, N, Kenna, K P, Soragia-Gkazi, A, Miller, J W, Sato, A, Dias, D M, Jeon, M, Vance, C, Wong, C H, de Majo, M, Kattuah, W, Mitchell, J C, Scotter, E L, Parkin, N W, Sapp, P C, Nolan, M, Nestor, P J, Simpson, M, Weale, M, Lek, M, Baas, F, Vianney de Jong, J M, Ten Asbroek, A L M A, Redondo, A G, Esteban-Pérez, J, Tiloca, C, Verde, F, Duga, S, Leigh, N, Pall, H, Morrison, K E, Al-Chalabi, A, Shaw, P J, Kirby, J, Turner, M R, Talbot, K, Hardiman, O, Glass, J D, De Belleroche, J, Maki, M, Moss, S E, Miller, C, Gellera, C, Ratti, A, Al-Sarraj, S, Brown, R H, Silani, V, Landers, J E & Shaw, C E 2017, ' Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis ', Science Translational Medicine, vol. 9, no. 388, eaad9157 . https://doi.org/10.1126/scitranslmed.aad9157
Science translational medicine, 9(388). American Association for the Advancement of Science
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Smith, B N, Topp, S D, Fallini, C, Shibata, H, Chen, H-J, Troakes, C, King, A, Ticozzi, N, Kenna, K P, Soragia-Gkazi, A, Miller, J W, Sato, A, Dias, D M, Jeon, M, Vance, C, Wong, C H, de Majo, M, Kattuah, W, Mitchell, J C, Scotter, E L, Parkin, N W, Sapp, P C, Nolan, M, Nestor, P J, Simpson, M, Weale, M, Lek, M, Baas, F, Vianney de Jong, J M, Ten Asbroek, A L M A, Redondo, A G, Esteban-Pérez, J, Tiloca, C, Verde, F, Duga, S, Leigh, N, Pall, H, Morrison, K E, Al-Chalabi, A, Shaw, P J, Kirby, J, Turner, M R, Talbot, K, Hardiman, O, Glass, J D, De Belleroche, J, Maki, M, Moss, S E, Miller, C, Gellera, C, Ratti, A, Al-Sarraj, S, Brown, R H, Silani, V, Landers, J E & Shaw, C E 2017, ' Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis ', Science Translational Medicine, vol. 9, no. 388, eaad9157 . https://doi.org/10.1126/scitranslmed.aad9157
Science translational medicine, 9(388). American Association for the Advancement of Science
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. We screened 751 familial ALS patient whole-exome sequences and identified six mutations including p.D40G in the ANXA11 gene in 13 individuals. The p.D40G mutation was absent f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b27a966da4ef46374f870b487a8486
https://doi.org/10.1126/scitranslmed.aad9157
https://doi.org/10.1126/scitranslmed.aad9157