Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Han-Cheng Zhang"'
Autor:
Bruce E. Maryanoff, Han-Cheng Zhang
Publikováno v:
ARKIVOC, Vol 2007, Iss 12, Pp 7-35 (2007)
Externí odkaz:
https://doaj.org/article/3ad87131bf574555a87189dd2acbe263
Autor:
Sengen Xu, Jeffrey Zhao, Aya Kobeissi, Hangbo Zhao, B.E. Perez White, John A. Rogers, Han-Cheng Zhang
Publikováno v:
Journal of Investigative Dermatology. 141:S88
Autor:
Tom Jay Parry, Bruce P. Damiano, Hong Ye, Barbara J. Haertlein, Cailin Chen, Bruce E. Maryanoff, Han-Cheng Zhang
Publikováno v:
ChemMedChem. 3:732-736
Whereas the activation and aggregation of blood platelets are crucial to normal hemostasis, this ensemble is also a key factor in serious cardiovascular disorders, such as myocardial infarction, unstable angina, transient ischemic attack, stroke, per
Autor:
Lisa Minor, John C. Spurlino, Alexander N. Barnakov, Stephen C. Yabut, Michael J. Costanzo, Kimberley B. White, Yuanping Wang, Brett A. Tounge, Cynthia M. Milligan, Bruce E. Maryanoff, Han-Cheng Zhang, Frank A. Lewandowski
Publikováno v:
Letters in Drug Design & Discovery. 5:116-121
Autor:
Han-Cheng Zhang, Bruce E. Maryanoff
Publikováno v:
ARKIVOC, Vol 2007, Iss 12, Pp 7-35 (2007)
We have been investigating the formation of macrocycles from α,ω-diynes in Co(I)-mediated cocyclotrimerization reactions. In these metal-mediated [2 + 2 + 2] cycloadditions, long-chain α,ωdiynes were reacted with nitriles, cyanamides, or isocyana
Autor:
Claudia K. Derian, Bruce E. Maryanoff, Han-Cheng Zhang, Patricia Andrade Gordon, Bruce P. Damiano
Publikováno v:
Cardiovascular Drug Reviews. 21:313-326
Protease activated receptor-1 (PAR-1) is a key mediator of the cellular actions of alpha-thrombin. Thus, antagonism of this unique G-protein coupled receptor with a small molecule represents a means of selectively inhibiting thrombin's cellular actio
Autor:
Jian Li, Diane A. Gauthier, Gregory C. Leo, Bruce E. Maryanoff, Llorente V. R. Bonaga, Hong Ye, Alessandro F. Moretto, Han-Cheng Zhang
Publikováno v:
Journal of the American Chemical Society. 127:3473-3485
We investigated the formation of macrocycles from alpha,omega-diynes in cobalt-mediated co-cyclotrimerization reactions. Long-chain alpha,omega-diynes underwent metal-mediated [2 + 2 + 2] cycloadditions with nitriles, cyanamides, or isocyanates in th
Autor:
Hong Ye, Annette J. Eckardt, Charles E. Smith, Han-Cheng Zhang, David F. McComsey, Bruce E. Maryanoff, Wai-man Cheung, Bruce P. Damiano, Claudia K. Derian, Keith T. Demarest, Stuart Emanuel, Patricia Andrade-Gordon, Kimberly White, Diane R. Croll, Bruce R. Conway, Leonard R. Hecker, Michael F. Addo, Jian Li, Quan Li
Publikováno v:
Journal of Medicinal Chemistry. 48:1725-1728
Novel indolylindazolylmaleimides were synthesized and examined for kinase inhibition. We identified low-nanomolar inhibitors of PKC-beta with good to excellent selectivity vs other PKC isozymes and GSK-3beta. In a cell-based functional assay, 8f and
Publikováno v:
Drug Development Research. 59:355-366
The serine protease α-thrombin is a powerful mediator of cellular responses, not only playing a key regulatory role in the maintenance of normal hemostasis, but also contributing more broadly to a range of physiological and potentially pathological
Publikováno v:
Current Medicinal Chemistry-Cardiovascular & Hematological Agents. 1:13-36
Protease-activated receptors (PARs) represent a unique family of seven-transmembrane G-protein-coupled receptors, which are enzymatically cleaved to expose a new extracellular N-terminus that acts as a tethered activating ligand. PAR-1 is cleaved and