A step-by-step approach to study the influence of N-acetylation on the adjuvanticity of N,N,N-trimethyl chitosan (TMC) in an intranasal nanoparticulate influenza virus vaccine

Autor: Ethlinn V.B. van Gaal, Niels Hagenaars, Rolf J. Verheul, Wim E. Hennink, Thomas van Es, J.G.M. Heldens, Han van den Bosch, Bram Slütter, Pascal H.J.L.F. de Jong, Harrie L. Glansbeek, Enrico Mastrobattista, Ivo Que, Wim Jiskoot, Sven C. M. Bruijns

Publikováno v: Verheul, R J, Hagenaars, N, van Es, T, van Gaal, E V B, De Jong, P H J L, Bruijns, S C M, Mastrobattista, E, Slutter, B, Que, I, Heldens, J G M, van den Bosch, J F, Glansbeek, H L, Hennink, W E & Jiskoot, W 2012, ' A step-by-step approach to study the influence of N-acetylation on the adjuvanticity of N,N,N-trimethyl chitosan (TMC) in an intranasal nanoparticulate influenza virus vaccine ', European Journal of Pharmaceutical Sciences, vol. 45, no. 4, pp. 467-474 . https://doi.org/10.1016/j.ejps.2011.10.001
European Journal of Pharmaceutical Sciences, 45(4), 467-474. Elsevier
European Journal of Pharmaceutical Sciences, 45(4), 467-474

Recently we reported that reacetylation of N,N,N-trimethyl chitosan (TMC) reduced the adjuvant effect of TMC in mice after intranasal (i.n.) administration of whole inactivated influenza virus (WIV) vaccine. The aim of the present study was to elucid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2805f81cd6a874130bfba468c4a6c5fa
https://doi.org/10.1016/j.ejps.2011.10.001

PB2 and PA genes control the expression of the temperature-sensitive phenotype of cold-adapted B/USSR/60/69 influenza master donor virus

Autor: Irina Kiseleva, Han van den Bosch, Jacco G. M. Heldens, Stephanie M. C. Basten, J. Theo M. Voeten, N V Larionova, Sandra K. M. Drieszen-van der Cruijsen, L. C. P. Teley, Larisa Rudenko

Publikováno v: Kiseleva, I V, Voeten, J T, Teley, L C, Larionova, N V, Drieszen-van der Cruijsen, S K, Basten, S M, Heldens, J G, van den Bosch, H & Rudenko, L G 2010, ' PB2 and PA genes control the expression of the temperature-sensitive phenotype of cold-adapted B/USSR/60/69 influenza master donor virus ', Journal of General Virology, vol. 91, pp. 931-937 . https://doi.org/10.1099/vir.0.017996-0
Journal of General Virology, 91, 931-937. Society for General Microbiology

The cold-adapted (ca) and temperature-sensitive (ts) influenza master donor virus (MDV) B/USSR/60/69 was derived from its wild-type parental virus after successive passages in eggs at 32 degrees C and 25 degrees C. This strain is currently in use for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5782c5c44a9a8f502e4c8941a97da634
https://research.vu.nl/en/publications/db3a4b09-b198-43f2-91b5-c9b51f18f9c3

Head-to-head comparison of four nonadjuvanted inactivated cell culture-derived influenza vaccines: Effect of composition, spatial organization and immunization route on the immunogenicity in a murine challenge model

Autor: Niels Hagenaars, Herman Vromans, Enrico Mastrobattista, Virgil E.J.C. Schijns, Harrie L. Glansbeek, Wim Jiskoot, Han van den Bosch, Didier Betbeder, J.G.M. Heldens

Publikováno v: Vaccine. 26:6555-6563

In order to study the influence of antigen composition, spatial organization of antigen and the route of administration, four cell culture-derived, inactivated, nonadjuvanted influenza vaccine formulations, i.e. whole inactivated virus (WIV), split,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79be228432d7c7b0ee4f4fa1e5ac3d31
https://doi.org/10.1016/j.vaccine.2008.09.057

Safety and immunogenicity in man of a cell culture derived trivalent live attenuated seasonal influenza vaccine: a Phase I dose escalating study in healthy volunteers

Autor: Larissa Rudenko, Pierre Van Damme, Theo Voeten, J.G.M. Heldens, Belinda Breedveld, Wilbert van Duijnhoven, Pierre Verweij, Han van den Bosch, Ellen G. J. Hulskotte

Publikováno v: Vaccine

Live attenuated influenza vaccine (LAIV) offers the promise of inducing a variety of immune responses thereby conferring protection to circulating field strains. LAIVs are based on cold adapted and temperature sensitive phenotypes of master donor vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39deeb4c64d7d049b43879054ad22141
https://pubmed.ncbi.nlm.nih.gov/24858566

Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine

Autor: Niels Hagenaars, Clemens W.G.M. Löwik, Jacco G. M. Heldens, Harrie L. Glansbeek, Han van den Bosch, Wim Jiskoot, Bram Slütter, Eric L. Kaijzel, Rob Nieuwland, Ivo Que, Enrico Mastrobattista, Pascal H.J.L.F. de Jong, Marta Mania

Publikováno v: Journal of Controlled Release, 144(1), 17-24
Journal of Controlled Release, 144(1), 17-24. Elsevier
Hagenaars, N, Mania, M, De Jong, P, Que, I, Nieuwland, R, Slütter, B, Glansbeek, H, Heldens, J, van den Bosch, H, Löwik, C, Kaijzel, E L, Mastrobattista, E & Jiskoot, W 2010, ' Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine ', Journal of Controlled Release, vol. 144, no. 1, pp. 17-24 . https://doi.org/10.1016/j.jconrel.2010.01.027

The nose is a promising immunization site and intranasal (in.) vaccination studies with whole inactivated influenza virus (WIV) adjuvanted with N,N,N-trimethylchitosan (TMC-WIV) have shown promising results. In this study, the influence of TMC on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7ec3d29fcc22c71e383d07c8b31d70
https://pubmed.ncbi.nlm.nih.gov/20100528