Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Han Wee Ong"'
Autor:
Han Wee Ong, Xuan Yang, Jeffery L. Smith, Sharon Taft-Benz, Stefanie Howell, Rebekah J. Dickmander, Tammy M. Havener, Marcia K. Sanders, Jason W. Brown, Rafael M. Couñago, Edcon Chang, Andreas Krämer, Nathaniel J. Moorman, Mark Heise, Alison D. Axtman, David H. Drewry, Timothy M. Willson
Publikováno v:
Molecules, Vol 29, Iss 17, p 4158 (2024)
The host kinase casein kinase 2 (CSNK2) has been proposed to be an antiviral target against β-coronaviral infection. To pharmacologically validate CSNK2 as a drug target in vivo, potent and selective CSNK2 inhibitors with good pharmacokinetic proper
Externí odkaz:
https://doaj.org/article/62c77468b14449aaab38290f68c9e3ba
Autor:
Xuan Yang, Han Wee Ong, Rebekah J. Dickmander, Jeffery L. Smith, Jason W. Brown, William Tao, Edcon Chang, Nathaniel J. Moorman, Alison D. Axtman, Timothy M. Willson
Publikováno v:
ACS Omega, Vol 8, Iss 42, Pp 39546-39561 (2023)
Externí odkaz:
https://doaj.org/article/4d7b606ed5844499b2833820f6af20b2
Autor:
Anna Castano, Margaux Silvestre, Carrow I Wells, Jennifer L Sanderson, Carla A Ferrer, Han Wee Ong, Yi Lang, William Richardson, Josie A Silvaroli, Frances M Bashore, Jeffery L Smith, Isabelle M Genereux, Kelvin Dempster, David H Drewry, Navlot S Pabla, Alex N Bullock, Tim A Benke, Sila K Ultanir, Alison D Axtman
Publikováno v:
eLife, Vol 12 (2023)
Pathological loss-of-function mutations in cyclin-dependent kinase-like 5 (CDKL5) cause CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental disorder associated with severe and medically refractory early-life epilepsy, motor, cogniti
Externí odkaz:
https://doaj.org/article/1bf476386b1149818536f2b15c6067c9
Autor:
Frances M. Bashore, Caroline A. Foley, Han Wee Ong, Justin M. Rectenwald, Ronan P. Hanley, Jacqueline L. Norris-Drouin, Stephanie H. Cholensky, Christine A. Mills, Kenneth H. Pearce, Laura E. Herring, Dmitri Kireev, Stephen V. Frye, Lindsey I. James
Publikováno v:
ACS Chemical Biology. 18:494-507
Publikováno v:
Expert Opinion on Therapeutic Targets. 27:151-169
Autor:
Kareem A. Galal, Anna Truong, Frank Kwarcinski, Chandi de Silva, Krisha Avalani, Tammy M. Havener, Michael E. Chirgwin, Eric Merten, Han Wee Ong, Caleb Willis, Ahmad Abdelwaly, Mohamed A. Helal, Emily R. Derbyshire, Reena Zutshi, David H. Drewry
Publikováno v:
Journal of Medicinal Chemistry. 65:13172-13197
Autor:
Han Wee Ong, Yi Liang, William Richardson, Emily R. Lowry, Carrow I. Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A. Silvaroli, Jeffery L. Smith, Hynek Wichterle, Navjot S. Pabla, Sila K. Ultanir, Alex N. Bullock, David H. Drewry, Alison D. Axtman
Publikováno v:
bioRxiv
Despite mediating several essential processes in the brain, including during development, cyclin-dependent kinase-like 5 (CDKL5) remains a poorly characterized human protein kinase. Accordingly, its substrates, functions, and regulatory mechanisms ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fbfb1603d4bbbd78dfe7ffaa08e876
https://doi.org/10.1101/2023.02.09.527935
https://doi.org/10.1101/2023.02.09.527935
Autor:
Anderson, Brian, Rosston, Peter, Han Wee Ong, Hossain, Mohammad Anwar, Davis-Gilbert, Zachary W., Drewry, David H.
Publikováno v:
Biochemical Journal; Aug2023, Vol. 480 Issue 16, p1331-1363, 33p
Autor:
Castano, Anna, Silvestre, Margaux, Wells, Carrow I., Sanderson, Jennifer L., Ferrer, Carla A., Han Wee Ong, Yi Lang, Richardson, William, Silvaroli, Josie A., Bashore, Frances M., Smith, Jeffery L., Genereux, Isabelle M., Dempster, Kelvin, Drewry, David H., Pabla, Navlot S., Bullock, Alex N., Benke, Tim A., Ultanir, Sila K., Axtman, Alison D.
Publikováno v:
eLife; 8/7/2023, p1-32, 32p
Autor:
Zhen Xuan Wong, Han Wee Ong, Ren Kai Edward Neo, Rakesh Ganguly, Yong Leng Kelvin Tan, Elumalai Kumaran, Weng Kee Leong
Publikováno v:
Journal of Cluster Science. 33:2337-2343
The tetraruthenium tetrahydrido carbonyl cluster Ru4(µ-H)4(CO)12 (1) reacts with diphenylvinylphosphine under thermal activation to give the substitution products Ru4(µ-H)4(CO)12−n(κ1-Ph2PCH=CH2)n, (2) (n = 3 (a); 4 (b)). Both 2a and 2b have bee