Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Han Sun Kim"'
Autor:
Kyung Hee Jung, Sujin Lee, Han Sun Kim, Jin-Mo Kim, Yun Ji Lee, Min Seok Park, Myeong-Seong Seo, Misu Lee, Mijin Yun, Sunghyouk Park, Soon-Sun Hong
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 3, Pp 721-733 (2024)
Abstract Acetyl-CoA synthetase 2 (ACSS2)-dependent acetate usage has generally been associated with tumorigenesis and increased malignancy in cancers under nutrient-depleted conditions. However, the nutrient usage and metabolic characteristics of the
Externí odkaz:
https://doaj.org/article/3893a9536dae4894a412178b25903b59
Autor:
Yong Jin An, Sihyang Jo, Jin-Mo Kim, Han Sun Kim, Hyun Young Kim, Sang-Min Jeon, Dawool Han, Jong In Yook, Keon Wook Kang, Sunghyouk Park
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 10, Pp 2238-2247 (2023)
Abstract Histone acetylation involves the transfer of two-carbon units to the nucleus that are embedded in low-concentration metabolites. We found that lactate, a high-concentration metabolic byproduct, can be a major carbon source for histone acetyl
Externí odkaz:
https://doaj.org/article/e69d02050b8b4d38b7788ff7308d38d4
Autor:
Tin Tin Manh Nguyen, Thi Ha Nguyen, Han Sun Kim, Thien T. P. Dao, Yechan Moon, Munjun Seo, Sunmi Kang, Van-Hieu Mai, Yong Jin An, Cho-Rok Jung, Jin-Mo Kim, Sunghyouk Park
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-21 (2023)
Abstract Background Clear cell renal cell carcinoma (ccRCC), with its hallmark phenotype of high cytosolic lipid content, is considered a metabolic cancer. Despite the implication of this lipid-rich phenotype in ccRCC tumorigenesis, the roles and reg
Externí odkaz:
https://doaj.org/article/af508a9b68684059a7280c13bbbee058
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 7, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/cd99b2717b584580ace5eb7d6677a706
Autor:
Woong Sub Byun, Won Kyung Kim, Hae Ju Han, Hwa-Jin Chung, Kyungkuk Jang, Han Sun Kim, Sunghwa Kim, Donghwa Kim, Eun Seo Bae, Sunghyouk Park, Jeeyeon Lee, Hyeung-geun Park, Sang Kook Lee
Publikováno v:
Molecular Therapy: Oncolytics, Vol 15, Iss , Pp 140-152 (2019)
Triple-negative breast cancer (TNBC) is the most intractable cancer in women with a high risk of metastasis. While hyper-methylation of histone H3 catalyzed by disruptor of telomeric silencing 1-like (DOT1L), a specific methyltransferase for histone
Externí odkaz:
https://doaj.org/article/710da8fe56c04d2f8fa3bd09c61234b3
Autor:
Sehyun Oh, Sihyang Jo, Martina Bajzikova, Han Sun Kim, Thien T. P. Dao, Jakub Rohlena, Jin-Mo Kim, Jiri Neuzil, Sunghyouk Park
Publikováno v:
Theranostics. 13:438-457
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfd48fce64e22b9f304442d349be346c
https://doi.org/10.7150/thno.75973
https://doi.org/10.7150/thno.75973
Autor:
Seong-Min Kim, Eun-Ji Kwon, Ji-Young Oh, Han Sun Kim, Sunghyouk Park, Goo Jang, Jeong Tae Do, Keun-Tae Kim, Hyuk-Jin Cha
Embryonic and epiblast stem cells in pre-and post-implantation embryos are characterized by their naive and primed states, respectively, which represent distinct phases of pluripotency. Thus, the cellular transition from naive to primed pluripotency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef56b0c3fa814f8c5bca16933cae3c14
https://doi.org/10.1101/2023.05.19.541467
https://doi.org/10.1101/2023.05.19.541467
Autor:
Han Sun Kim, Bo-Reum Kim, Thien T. P. Dao, Jin-Mo Kim, Yoon-Joo Kim, Hyunsong Son, Sihyang Jo, Doyeon Kim, Jiwoo Kim, Young Ju Suh, Hee Je Kim, Byung-Sik Cho, Sunghyouk Park
Publikováno v:
Blood Advances.
Acute myeloid leukemia (AML) generally has an unsatisfactory prognosis despite recent introduction of new regimens including targeted agents and antibodies. To find a new druggable pathway, we performed integrated bioinformatic pathway screening on l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4da7653782fc12ca6fd6ff0f63d9f78b
https://doi.org/10.1182/bloodadvances.2022007956
https://doi.org/10.1182/bloodadvances.2022007956
Autor:
Sehyun Oh, Sihyang Jo, Han Sun Kim, Van-Hieu Mai, Berwini Endaya, Jiri Neuzil, Kyung Hee Jung, Soon-Sun Hong, Jin-Mo Kim, Sunghyouk Park
Publikováno v:
Analytical Chemistry.
Early diagnosis of hepatocellular carcinoma (HCC) is difficult; the lack of convenient biomarker-based diagnostic modalities renders high-risk HCC patients burdened by life-long periodical examinations. Here, a new chemical biopsy approach was develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7eca071d8ade42d2ae11a0e948b616
https://doi.org/10.1021/acs.analchem.2c03944
https://doi.org/10.1021/acs.analchem.2c03944
Autor:
Sunghyouk Park, Yong Jin An, Sihyang Jo, Jin-Mo Kim, Han Sun Kim, Hyun Young Kim, Sang-Min Jeon, Dawool Han, Jong In Yook, Keon Wook Kang
Histone acetylation involves the transfer of a two-carbon unit to nucleus as embedded in low-concentration metabolites. We find that lactate, a high-concentration metabolic by-product, can be a major carbon source for histone acetylation, through oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3307a941fa096fadfd1ecddd087b28ee
https://doi.org/10.21203/rs.3.rs-1698453/v1
https://doi.org/10.21203/rs.3.rs-1698453/v1