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Akademický článek

High-Fidelity Cytosine Base Editing in a GC-Rich Corynebacterium glutamicum with Reduced DNA Off-Target Editing Effects

Autor: Yu Been Heo, Gue-Ho Hwang, Seok Won Kang, Sangsu Bae, Han Min Woo

Publikováno v: Microbiology Spectrum, Vol 10, Iss 6 (2022)

ABSTRACT Genome editing technology is a powerful tool for programming microbial cell factories. However, rat APOBEC1-derived cytosine base editor (CBE) that converts C•G to T•A at target genes induced DNA off-targets, regardless of single-guide R

Externí odkaz: https://doaj.org/article/1d8034cd5a9144beb362000dac4378a5

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Akademický článek

Bioconversion of Xylose to Ethylene Glycol and Glycolate in Engineered Corynebacterium glutamicum

Autor: Seung Soo Lee, Jong-il Choi, Han Min Woo

Publikováno v: ACS Omega, Vol 4, Iss 25, Pp 21279-21287 (2019)

Externí odkaz: https://doaj.org/article/0dc704e2d51e46d2a1c0ab9a9d5a6e11

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Akademický článek

RNA-guided single/double gene repressions in Corynebacterium glutamicum using an efficient CRISPR interference and its application to industrial strain

Autor: Jaehyun Park, Hyojung Shin, Sun-Mi Lee, Youngsoon Um, Han Min Woo

Publikováno v: Microbial Cell Factories, Vol 17, Iss 1, Pp 1-10 (2018)

Abstract Background The construction of microbial cell factories requires cost-effective and rapid strain development through metabolic engineering. Recently, RNA-guided CRISPR technologies have been developed for metabolic engineering of industriall

Externí odkaz: https://doaj.org/article/eca46fd4b33149a8920b3ccf93acddeb

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Akademický článek

Perspectives for biocatalytic lignin utilization: cleaving 4-O-5 and Cα–Cβ bonds in dimeric lignin model compounds catalyzed by a promiscuous activity of tyrosinase

Autor: Kyoungseon Min, Taewoo Yum, Jiye Kim, Han Min Woo, Yunje Kim, Byoung-In Sang, Young Je Yoo, Yong Hwan Kim, Youngsoon Um

Publikováno v: Biotechnology for Biofuels, Vol 10, Iss 1, Pp 1-8 (2017)

Abstract Background In the biorefinery utilizing lignocellulosic biomasses, lignin decomposition to value-added phenolic derivatives is a key issue, and recently biocatalytic delignification is emerging owing to its superior selectivity, low energy c

Externí odkaz: https://doaj.org/article/94d314fd65134f71b3e69ed43368c81d

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Akademický článek

High Production of 2,3-Butanediol (2,3-BD) by Raoultella ornithinolytica B6 via Optimizing Fermentation Conditions and Overexpressing 2,3-BD Synthesis Genes.

Autor: Taeyeon Kim, Sukhyeong Cho, Sun-Mi Lee, Han Min Woo, Jinwon Lee, Youngsoon Um, Jin-Ho Seo

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0165076 (2016)

Biological production of 2,3-butandiol (2,3-BD) has received great attention as an alternative to the petroleum-based 2,3-BD production. In this study, a high production of 2,3-BD in fed-batch fermentation was investigated with a newly isolated bacte

Externí odkaz: https://doaj.org/article/0d8415f953d842f8a4d311c7f67deefe

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Akademický článek

Enhanced 2,3-Butanediol Production by Optimizing Fermentation Conditions and Engineering Klebsiella oxytoca M1 through Overexpression of Acetoin Reductase.

Autor: Sukhyeong Cho, Taeyeon Kim, Han Min Woo, Jinwon Lee, Yunje Kim, Youngsoon Um

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0138109 (2015)

Microbial production of 2,3-butanediol (2,3-BDO) has been attracting increasing interest because of its high value and various industrial applications. In this study, high production of 2,3-BDO using a previously isolated bacterium Klebsiella oxytoca

Externí odkaz: https://doaj.org/article/856e346e85594bcb9301d056ab247143

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