To Be, or Notch to Be: Mediating Cell Fate from Embryogenesis to Lymphopoiesis

Autor: Han Leng Ng, Elizabeth Quail, Mark N. Cruickshank, Daniela Ulgiati

Publikováno v: Biomolecules, Vol 11, Iss 6, p 849 (2021)

Notch signaling forms an evolutionarily conserved juxtacrine pathway crucial for cellular development. Initially identified in Drosophila wing morphogenesis, Notch signaling has since been demonstrated to play pivotal roles in governing mammalian cel

Externí odkaz: https://doaj.org/article/03094f2293e24ad0a2e2905ef392c93d

Notch signaling induces a transcriptionally permissive state at the Complement C3d Receptor 2 (CR2) promoter in a pre-B cell model

Autor: Jessica Cheng, Elizabeth Quail, Mark N. Cruickshank, Han Leng Ng, Rhonda L. Taylor, Daniela Ulgiati, Lawrence J. Abraham

Publikováno v: Molecular Immunology. 128:150-164

During mammalian lymphoid development, Notch signaling is necessary at multiple stages of T lymphopoiesis, including lineage commitment, and later stages of T cell effector differentiation. In contrast, outside of a defined role in the development of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2ec67be2da06523f631b0efafd3b3b
https://doi.org/10.1016/j.molimm.2020.10.001

Disease-associated missense variants in ZBTB18 disrupt DNA binding and impair the development of neurons within the embryonic cerebral cortex

Autor: Mark Agostino, Olivier Clément, Ivan Gladwyn-Ng, Julian Ik-Tsen Heng, Kevin D. G. Pfleger, Han Leng Ng, Isabel A. Hemming, Hayley Daniella Cullen, Daniela Ulgiati, Heng B. See, Linh Ngo

Publikováno v: Human mutation. 40(10)

The activities of DNA-binding transcription factors, such as the multi-zinc-finger protein ZBTB18 (also known as RP58, or ZNF238), are essential to coordinate mammalian neurodevelopment, including the birth and radial migration of newborn neurons wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15634ace9a3f46ee587d485b8ad47b4
https://pubmed.ncbi.nlm.nih.gov/31112317

Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA

Autor: Zhao, Jian, Giles, Brendan M., Taylor, Rhonda L., Yette, Gabriel A., Lough, Kara M., Han Leng, Ng, Abraham, Lawrence J., Hui, Wu, Kelly, Jennifer A., Glenn, Stuart B., Adler, Adam J., Williams, Adrienne H., Comeau, Mary E., Ziegler, Julie T., Marion, Miranda, Alarcón Riquelme, Marta E., Alarcón, Graciela S., Anaya, Juan Manuel, Bae, Sang Cheol, Kim, Dam, Lee, Hye Soon, Criswell, Lindsey A., Freedman, Barry I., Gilkeson, Gary S., Guthridge, Joel M., Jacob, Chaim O., James, Judith A., Kamen, Diane L., Merrill, Joan T., Sivils, Kathy Moser, Niewold, Timothy B., Petri, Michelle A., Ramsey Goldman, Rosalind, Reveille, John D., Scofield, R. Hal, Stevens, Anne M., Vilá, Luis M., Vyse, Timothy J., Kaufman, Kenneth M., Harley, John B., Langefeld, Carl D., Gaffney, Patrick M., Brown, Elizabeth E., Edberg, Jeffrey C., Kimberly, Robert P., Ulgiati, Daniela, Tsao, Betty P., Boackle, Susan A., Frostegård, Johan, Truedsson, Lennart, De Ramón, Enrique, Sabio, José M., González Escribano, María F., Martin, Javier, Ortego Centeno, Norberto, Callejas, José Luis, Sánchez Román, Julio, D'Alfonso, Sandra, Migliarese, Sergio, Sebastiani, Gian Domenico, Galeazzi, Mauro, Witte, Torsten, Lauwerys, Bernard R., Endreffy, Emoke, Kovács, László, Vasconcelos, Carlos, Da Silva, Berta Martins, Scherbarth, R., Marino, Pilar C., Motta, Estela L., Gamron, Susana, Drenkard, Cristina, Menso, Emilia, Allievi, Alberto, Tate, Guillermo A., Presas, Jose L., Palatnik, Simon A., Abdala, Marcelo, Bearzotti, Mariela, Alvarellos, Alejandro, Caeiro, Francisco, Bertoli, Ana, Paira, Sergio, Roverano, Susana, Graf, Cesar E., Bertero, Estela, Caprarulo, Cesar, Buchanan, Griselda, Guillerón, Carolina, Grimaudo, Sebastian, Manni, Jorge, Catoggio, Luis J., Soriano, Enrique R., Santos, Carlos D., Prigione, Cristina, Ramos, Fernando A., Navarro, Sandra M., Berbotto, Guillermo A., Jorfen, Marisa, Romero, Elisa J., Garcia, Mercedes A., Marcos, Juan C., Marcos, Ana I., Perandones, Carlos E., Eimon, Alicia, Parque, Sanatorio, Battagliotti, Cristina G., Acevedo, Eduardo, Cucho, Mariano, De La Torre, Ignacio García, Ríos, Mario Cardiel, Moctezuma, José Francisco, Ceceña, Marco Maradiaga

Publikováno v: Zhao, J, Giles, B M, Taylor, R L, Yette, G A, Lough, K M, Ng, H L, Abraham, L J, Wu, H, Kelly, J A, Glenn, S B, Adler, A J, Williams, A H, Comeau, M E, Ziegler, J T, Marion, M, Alarcón-Riquelme, M E, Alarcón, G S, Anaya, J M, Bae, S C, Kim, D, Lee, H S, Criswell, L A, Freedman, B I, Gilkeson, G S, Guthridge, J M, Jacob, C O, James, J A, Kamen, D L, Merrill, J T, Sivils, K M, Niewold, T B, Petri, M A, Ramsey-Goldman, R, Reveille, J D, Scofield, R H, Stevens, A M, Vilá, L M, Vyse, T J, Kaufman, K M, Harley, J B, Langefeld, C D, Gaffney, P M, Brown, E E, Edberg, J C, Kimberly, R P, Ulgiati, D, Tsao, B P & Boackle, S A 2016, ' Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA ', Annals of the Rheumatic Diseases, vol. 75, no. 1 . https://doi.org/10.1136/annrheumdis-2014-205584
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
Annals of the Rheumatic Diseases

Objectives Systemic lupus erythematosus (SLE; OMIM 152700) is characterised by the production of antibodies to nuclear antigens. We previously identified variants in complement receptor 2 (CR2/CD21) that were associated with decreased risk of SLE. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e1d071311efb80c5192b03dbbfaef4
https://kclpure.kcl.ac.uk/en/publications/89fcb3b5-73a6-4242-ac43-07d6b68cfb83