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SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin

Autor: Huiqiang eChen, Xianbao eLiu, Wei eZhu, Han eChen, Xinyang eHu, Zhi eJiang, Yinchuan eXu, Lihan eWang, Yu eZhou, Panpan eChen, Na eZhang, Dexing eHu, Ling eZhang, Yaping eWang, Qiyuan eXu, Rongrong eWu, Hong eYu, Jian-an eWang

Publikováno v: Frontiers in Aging Neuroscience, Vol 6 (2014)

Age-related mesenchymal stem cells (MSCs) senescence, which impairs its tissue repair capacity in vivo and hence compromises the effects of MSCs-based therapy in clinical applications, is closely related to aging and aging-related diseases. Here, we

Externí odkaz: https://doaj.org/article/a96221a59d314e95b069d081d3afcb98

Quantification method of ctDNA using cell-free DNA methylation profile for noninvasive screening and monitoring of colon cancer.

Autor: Ryu H; Clinomics, Inc., Ulsan, 44919, Republic of Korea., Kim JH; Clinomics, Inc., Ulsan, 44919, Republic of Korea.; GenomeLab, Korean Genomics Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.; Department of Biomedical Engineering, College of Information and Biotechnology, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Kim YJ; Clinomics, Inc., Ulsan, 44919, Republic of Korea., Jeon H; Clinomics, Inc., Ulsan, 44919, Republic of Korea., Kim BC; Clinomics, Inc., Ulsan, 44919, Republic of Korea., Jeon Y; Clinomics, Inc., Ulsan, 44919, Republic of Korea., Kim Y; Clinomics, Inc., Ulsan, 44919, Republic of Korea., Bak H; Clinomics, Inc., Ulsan, 44919, Republic of Korea., Kang Y; Clinomics, Inc., Ulsan, 44919, Republic of Korea., Kim C; Clinomics, Inc., Ulsan, 44919, Republic of Korea., Um H; Clinomics, Inc., Ulsan, 44919, Republic of Korea., Ahn JH; Clinomics, Inc., Ulsan, 44919, Republic of Korea., Hyun H; Clinomics, Inc., Ulsan, 44919, Republic of Korea., Kim BC; Clinomics, Inc., Ulsan, 44919, Republic of Korea., Song I; Division of Colorectal Surgery, Department of Surgery, Dongnam Institute of Radiological and Medical Sciences, Busan, 46033, Republic of Korea., Jeon S; Clinomics, Inc., Ulsan, 44919, Republic of Korea. jsw0061@gmail.com.; Geromics Inc., Suwon, 16229, Republic of Korea. jsw0061@gmail.com., Bhak J; Clinomics, Inc., Ulsan, 44919, Republic of Korea. jongbhak@genomics.org.; GenomeLab, Korean Genomics Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea. jongbhak@genomics.org.; Department of Biomedical Engineering, College of Information and Biotechnology, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea. jongbhak@genomics.org.; Geromics Inc., Suwon, 16229, Republic of Korea. jongbhak@genomics.org.; Personal Genomics Institute (PGI), Genome Research Foundation (GRF), Cheongju, 28160, Republic of Korea. jongbhak@genomics.org., Han EC; Division of Colorectal Surgery, Department of Surgery, Dongnam Institute of Radiological and Medical Sciences, Busan, 46033, Republic of Korea. eonchulhan@dirams.re.kr.

Publikováno v: Clinical epigenetics [Clin Epigenetics] 2024 Jul 19; Vol. 16 (1), pp. 95. Date of Electronic Publication: 2024 Jul 19.

Characterization of 3D Organotypic Culture of Mouse Adipose-Derived Stem Cells.

Autor: Son TG; Research Center, Dongnam Institute of Radiological and Medical Science, Busan 46033, Republic of Korea., Seo Y; Department of Oral Biochemistry, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea., Kim WT; Research Center, Dongnam Institute of Radiological and Medical Science, Busan 46033, Republic of Korea., Kim M; Research Center, Dongnam Institute of Radiological and Medical Science, Busan 46033, Republic of Korea., Choi SJ; Research Center, Dongnam Institute of Radiological and Medical Science, Busan 46033, Republic of Korea., Choi SH; Research Center, Dongnam Institute of Radiological and Medical Science, Busan 46033, Republic of Korea., Sung BJ; Research Center, Dongnam Institute of Radiological and Medical Science, Busan 46033, Republic of Korea., Min JS; Department of Surgery, Dongnam Institute of Radiological and Medical Science, Busan 46033, Republic of Korea., Han EC; Department of Surgery, Dongnam Institute of Radiological and Medical Science, Busan 46033, Republic of Korea., Kim HS; Department of Oral Biochemistry, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 01; Vol. 25 (7). Date of Electronic Publication: 2024 Apr 01.

Quantitative and qualitative mutational impact of ionizing radiation on normal cells.

Autor: Youk J; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea., Kwon HW; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea; Department of Nuclear Medicine, Korea University College of Medicine, Seoul, Republic of Korea., Lim J; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Genome Insight, Inc., San Diego, CA 92121, USA., Kim E; Department of Radiation Oncology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, 20, Boramae-ro 5 Gil, Dongjak-gu, Seoul 07061, Republic of Korea; Department of Radiation Oncology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea., Kim T; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea., Kim R; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Genome Insight, Inc., San Diego, CA 92121, USA., Park S; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Genome Insight, Inc., San Diego, CA 92121, USA., Yi K; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Genome Insight, Inc., San Diego, CA 92121, USA., Nam CH; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea., Jeon S; Department of Biological Sciences & IMBG, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea., An Y; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea., Choi J; Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, CB2 0AW Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, CB2 3EL Cambridge, UK., Na H; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria., Lee ES; Research Center, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea., Cho Y; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea., Min DW; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea., Kim H; Research Center, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea., Kang YR; Research Center, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea., Choi SH; Research Center, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea., Bae MJ; Research Center, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea., Lee CG; Research Center, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea., Kim JG; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KI for Health Science and Technology, KAIST, Daejeon 34141, Republic of Korea., Kim YS; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KI for Health Science and Technology, KAIST, Daejeon 34141, Republic of Korea., Yu T; Department of Radiation Oncology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Radiation Oncology, Dongnam Institute of Radiological and Medical Science, Busan 46033, Republic of Korea., Lee WC; Genome Insight, Inc., San Diego, CA 92121, USA., Shin JY; Genome Insight, Inc., San Diego, CA 92121, USA., Lee DS; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea., Kim TY; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea., Ku T; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KI for Health Science and Technology, KAIST, Daejeon 34141, Republic of Korea., Kim SY; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea., Lee JH; Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, CB2 0AW Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, CB2 3EL Cambridge, UK., Koo BK; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria., Lee H; Department of Biological Sciences & IMBG, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea., Yi OV; Department of Breast Surgery, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea., Han EC; Department of Surgery, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea., Chang JH; Department of Radiation Oncology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address: jh.chang@snu.ac.kr., Kim KS; Department of Radiation Oncology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address: kskim.cirt@snu.ac.kr., Son TG; Research Center, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea. Electronic address: tgson@dirams.re.kr., Ju YS; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Genome Insight, Inc., San Diego, CA 92121, USA. Electronic address: ysju@kaist.ac.kr.

Publikováno v: Cell genomics [Cell Genom] 2024 Feb 14; Vol. 4 (2), pp. 100499.