Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Han Chow Chua"'
Autor:
Nazanin Azarinejad Mohammadi, Philip Kiær Ahring, Vivian Wan Yu Liao, Han Chow Chua, Sebastián Ortiz de la Rosa, Katrine Marie Johannesen, Yael Michaeli-Yossef, Aline Vincent-Devulder, Catherine Meridda, Ange-Line Bruel, Alessandra Rossi, Chirag Patel, Joerg Klepper, Paolo Bonanni, Sara Minghetti, Marina Trivisano, Nicola Specchio, David Amor, Stéphane Auvin, Sarah Baer, Pierre Meyer, Mathieu Milh, Vincenzo Salpietro, Reza Maroofian, Johannes R. Lemke, Sarah Weckhuysen, Palle Christophersen, Guido Rubboli, Mary Chebib, Anders A. Jensen, Nathan L. Absalom, Rikke Steensbjerre Møller
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105236- (2024)
Summary: Background: Variants in GABRB2, encoding the β2 subunit of the γ-aminobutyric acid type A (GABAA) receptor, can result in a diverse range of conditions, ranging from febrile seizures to severe developmental and epileptic encephalopathies.
Externí odkaz:
https://doaj.org/article/1f75a6fe61cf4a01b76139af961cda76
Autor:
Cameron L. Noland, Han Chow Chua, Marc Kschonsak, Stephanie Andrea Heusser, Nina Braun, Timothy Chang, Christine Tam, Jia Tang, Christopher P. Arthur, Claudio Ciferri, Stephan Alexander Pless, Jian Payandeh
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
NaX is an atypical member of the voltage-gated sodium channel family that may contribute to Na+ homeostasis. Here, the authors describe the structural and functional attributes of the human NaX channel to reveal new insights into its physiology.
Externí odkaz:
https://doaj.org/article/2f977168e29d4738843b01d6e6b08fea
Autor:
Han Chow Chua, Emilie T H Christensen, Kirsten Hoestgaard-Jensen, Leonny Y Hartiadi, Iqbal Ramzan, Anders A Jensen, Nathan L Absalom, Mary Chebib
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157700 (2016)
Extracts of the pepper plant kava (Piper methysticum) are effective in alleviating anxiety in clinical trials. Despite the long-standing therapeutic interest in kava, the molecular target(s) of the pharmacologically active constituents, kavalactones
Externí odkaz:
https://doaj.org/article/e699128614fe46f890b2a3e1b43c9fc5
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141359 (2015)
2'-Methoxy-6-methylflavone (2'MeO6MF) is an anxiolytic flavonoid which has been shown to display GABAA receptor (GABAAR) β2/3-subunit selectivity, a pharmacological profile similar to that of the general anaesthetic etomidate. Electrophysiological s
Externí odkaz:
https://doaj.org/article/b5f5a49c950e4e74b1671a4fa00d32f1
Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore region.
Autor:
Schott, Katharina, Usher, Samuel George, Serra, Oscar, Carnevale, Vincenzo, Pless, Stephan Alexander, Han Chow Chua
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 5/28/2024, Vol. 121 Issue 22, p1-12, 26p
The sodium (Na+) leak channel (NALCN) is a member of the four-domain voltage-gated cation channel family that includes the prototypical voltage-gated sodium and calcium channels (NaVs and CaVs, respectively). Unlike NaVs and CaVs, which have four int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9cb189afbf09cc0eafad0f42f278178
https://doi.org/10.1101/2023.04.12.536537
https://doi.org/10.1101/2023.04.12.536537
Autor:
Cameron L, Noland, Han Chow, Chua, Marc, Kschonsak, Stephanie Andrea, Heusser, Nina, Braun, Timothy, Chang, Christine, Tam, Jia, Tang, Christopher P, Arthur, Claudio, Ciferri, Stephan Alexander, Pless, Jian, Payandeh
Publikováno v:
Nature communications. 13(1)
Unlike classical voltage-gated sodium (Na
Autor:
Marc Kschonsak, Han Chow Chua, Claudia Weidling, Nourdine Chakouri, Cameron L. Noland, Katharina Schott, Timothy Chang, Christine Tam, Nidhi Patel, Christopher P. Arthur, Alexander Leitner, Manu Ben-Johny, Claudio Ciferri, Stephan Alexander Pless, Jian Payandeh
Publikováno v:
Kschonsak, M, Chua, H C, Weidling, C, Chakouri, N, Noland, C L, Schott, K, Chang, T, Tam, C, Patel, N, Arthur, C P, Leitner, A, Ben-Johny, M, Ciferri, C, Pless, S A & Payandeh, J 2022, ' Structural architecture of the human NALCN channelosome ', Nature, vol. 603, pp. 180–186 . https://doi.org/10.1038/s41586-021-04313-5
Depolarizing sodium (Na+) leak currents carried by the NALCN channel regulate the resting membrane potential of many neurons to modulate respiration, circadian rhythm, locomotion and pain sensitivity1–8. NALCN requires FAM155A, UNC79 and UNC80 to f
Autor:
Stephan A. Pless, Marie Vitello, Dominique Engel, Vincent Seutin, Sofian Ringlet, Laurent Massotte, Jean-François Liégeois, Jochen Roeper, Kevin Jehasse, Bernard Lakaye, Sebastian Hartmann, Han Chow Chua, Romain Vitello
Publikováno v:
Neuropharmacology. 197
Although several ionic mechanisms are known to control rate and regularity of the slow pacemaker in dopamine (DA) neurons, the core mechanism of pacing is controversial. Here we tested the hypothesis that pacemaking of SNc DA neurons is enabled by an